Santa Anna may refer to:
- Santa Anna, Texas, a town in Coleman County in Central Texas, United States
- Santa Anna, Starr County, Texas
- Santa Anna Township, DeWitt County, Illinois, one of townships in DeWitt County, Illinois, United States.
- Santa Anna (1522 ship), a 16th-century war ship of the Knights Hospitaller
- Santa Anna (1806 ship), a Spanish ship that a British privateer captured in 1806 that became a whaling ship
- Antonio López de Santa Anna (1794–1876), Mexican politician and general
- Santa Anna (Comanche war chief) (c. 1798–1849), Native American tribal leader
See also
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This disambiguation page lists articles associated with the title Santa Anna.
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