Syntaxin binding protein 2

STXBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CCA
Identifiers
Aliases	STXBP2, FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122, Syntaxin binding protein 2
External IDs	OMIM: 601717; MGI: 107370; HomoloGene: 55530; GeneCards: STXBP2; OMA:STXBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,647,873 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,693,644 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; mucosa of transverse colon; ; body of pancreas; ; upper lobe of left lung; ; right lung; ; right uterine tube; ; left testis; ; right lobe of thyroid gland; ; right testis;
	Top expressed in
	granulocyte; ; neural layer of retina; ; yolk sac; ; superior frontal gyrus; ; lip; ; right kidney; ; submandibular gland; ; saccule; ; duodenum; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; syntaxin-1 binding; syntaxin-3 binding;
Cellular component	cytolytic granule; tertiary granule; SNARE complex; azurophil granule; specific granule; apical plasma membrane; extracellular exosome; plasma membrane; zymogen granule membrane; extracellular region; cytosol; phagocytic vesicle;
Biological process	protein transport; neutrophil degranulation; vesicle docking involved in exocytosis; regulation of mast cell degranulation; leukocyte mediated cytotoxicity; vesicle-mediated transport; exocytosis; platelet degranulation; transport; cellular response to interferon-gamma;
	Sources:Amigo / QuickGO
Orthologs
	6813
	20911
	ENSG00000076944
	ENSMUSG00000004626
	Q15833
	Q64324
	NM_001127396; NM_001272034; NM_006949
	NM_011503; NM_001357168
	NP_001120868; NP_001258963; NP_008880
	NP_035633; NP_001344097
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ziegler SF, Mortrud MT, Swartz AR, Baker E, Sutherland GR, Burmeister M, Mulligan JT (Feb 1997). "Molecular characterization of a nonneuronal human UNC18 homolog". Genomics. 37 (1): 19–23. doi:10.1006/geno.1996.0515. PMID 8921365.19-23&rft.date=1997-02&rft_id=info:doi/10.1006/geno.1996.0515&rft_id=info:pmid/8921365&rft.aulast=Ziegler&rft.aufirst=SF&rft.au=Mortrud, MT&rft.au=Swartz, AR&rft.au=Baker, E&rft.au=Sutherland, GR&rft.au=Burmeister, M&rft.au=Mulligan, JT&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
^ "Entrez Gene: STXBP2 syntaxin binding protein 2".

Ibaraki K, Horikawa HP, Morita T, et al. (1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.997-1005&rft.date=1995&rft_id=info:doi/10.1006/bbrc.1995.1910&rft_id=info:pmid/7598732&rft.aulast=Ibaraki&rft.aufirst=K&rft.au=Horikawa, HP&rft.au=Morita, T&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.13022-8&rft.date=1995&rft_id=info:doi/10.1074/jbc.270.22.13022&rft_id=info:pmid/7768895&rft.aulast=Hata&rft.aufirst=Y&rft.au=Südhof, TC&rft_id=https://doi.org/10.1074%2Fjbc.270.22.13022&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.6179-86&rft.date=1997&rft_id=info:doi/10.1074/jbc.272.10.6179&rft_id=info:pmid/9045631&rft.aulast=Tellam&rft.aufirst=JT&rft.au=Macaulay, SL&rft.au=McIntosh, S&rft_id=https://doi.org/10.1074%2Fjbc.272.10.6179&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. doi:10.1242/jcs.111.17.2681. PMID 9701566.2681-8&rft.date=1999&rft_id=info:doi/10.1242/jcs.111.17.2681&rft_id=info:pmid/9701566&rft.aulast=Riento&rft.aufirst=K&rft.au=Galli, T&rft.au=Jansson, S&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.13476-83&rft.date=2000&rft_id=info:doi/10.1074/jbc.275.18.13476&rft_id=info:pmid/10788461&rft.aulast=Riento&rft.aufirst=K&rft.au=Kauppi, M&rft.au=Keranen, S&rft.au=Olkkonen, VM&rft_id=https://doi.org/10.1074%2Fjbc.275.18.13476&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.7540-5&rft.date=2002&rft_id=info:doi/10.1074/jbc.M110141200&rft_id=info:pmid/11748230&rft.aulast=Pellizzoni&rft.aufirst=L&rft.au=Baccon, J&rft.au=Rappsilber, J&rft_id=https://doi.org/10.1074%2Fjbc.M110141200&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.31957-62&rft.date=2002&rft_id=info:doi/10.1074/jbc.M203478200&rft_id=info:pmid/12065586&rft.aulast=Baccon&rft.aufirst=J&rft.au=Pellizzoni, L&rft.au=Rappsilber, J&rft_id=https://doi.org/10.1074%2Fjbc.M203478200&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.43973-9&rft.date=2003&rft_id=info:doi/10.1074/jbc.M208315200&rft_id=info:pmid/12198139&rft.aulast=Kauppi&rft.aufirst=M&rft.au=Wohlfahrt, G&rft.au=Olkkonen, VM&rft_id=https://doi.org/10.1074%2Fjbc.M208315200&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Martin-Verdeaux S, Pombo I, Iannascoli B, et al. (2003). "Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis". J. Cell Sci. 116 (Pt 2): 325–34. doi:10.1242/jcs.00216. PMID 12482918.325-34&rft.date=2003&rft_id=info:doi/10.1242/jcs.00216&rft_id=info:pmid/12482918&rft.aulast=Martin-Verdeaux&rft.aufirst=S&rft.au=Pombo, I&rft.au=Iannascoli, B&rft_id=https://doi.org/10.1242%2Fjcs.00216&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Houng A, Polgar J, Reed GL (2003). "Munc18-syntaxin complexes and exocytosis in human platelets". J. Biol. Chem. 278 (22): 19627–33. doi:10.1074/jbc.M212465200. PMID 12649283.19627-33&rft.date=2003&rft_id=info:doi/10.1074/jbc.M212465200&rft_id=info:pmid/12649283&rft.aulast=Houng&rft.aufirst=A&rft.au=Polgar, J&rft.au=Reed, GL&rft_id=https://doi.org/10.1074%2Fjbc.M212465200&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Schraw TD, Lemons PP, Dean WL, Whiteheart SW (2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.207-17&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223584#id-name=PMC&rft_id=info:pmid/12773094&rft_id=info:doi/10.1042/BJ20030610&rft.aulast=Schraw&rft.aufirst=TD&rft.au=Lemons, PP&rft.au=Dean, WL&rft.au=Whiteheart, SW&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223584&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-binding protein 2

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076944 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004626 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8921365-5] Ziegler SF, Mortrud MT, Swartz AR, Baker E, Sutherland GR, Burmeister M, Mulligan JT (Feb 1997). "Molecular characterization of a nonneuronal human UNC18 homolog". Genomics. 37 (1): 19–23. doi:10.1006/geno.1996.0515. PMID 8921365.19-23&rft.date=1997-02&rft_id=info:doi/10.1006/geno.1996.0515&rft_id=info:pmid/8921365&rft.aulast=Ziegler&rft.aufirst=SF&rft.au=Mortrud, MT&rft.au=Swartz, AR&rft.au=Baker, E&rft.au=Sutherland, GR&rft.au=Burmeister, M&rft.au=Mulligan, JT&rfr_id=info:sid/en.wikipedia.org:Syntaxin binding protein 2" class="Z3988">

[entrez-6] "Entrez Gene: STXBP2 syntaxin binding protein 2".

[5]

[6]

[1]

[2]

[3]

[4]

Syntaxin binding protein 2

References

Further reading

External links