STEAP1

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	90,164,829 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,799,326 bp
RNA expression pattern
	Top expressed in
	pericardium; ; cartilage tissue; ; prostate; ; tendon of biceps brachii; ; Achilles tendon; ; parietal pleura; ; gonad; ; mucosa of transverse colon; ; abdominal fat; ; gallbladder;
	Top expressed in
	Epithelium of choroid plexus; ; endothelial cell of lymphatic vessel; ; lumbar spinal ganglion; ; epithelium of lens; ; molar; ; hair follicle; ; yolk sac; ; adrenal gland; ; Paneth cell; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ferric-chelate reductase (NADPH) activity; metal ion binding; transporter activity; oxidoreductase activity; cupric reductase activity; channel activity;
Cellular component	endosome membrane; integral component of membrane; cell-cell junction; integral component of plasma membrane; membrane; endosome; plasma membrane;
Biological process	ion transport; copper ion import; iron ion homeostasis; transmembrane transport; iron ion import across cell outer membrane;
	Sources:Amigo / QuickGO
Orthologs
	26872
	70358
	ENSG00000164647
	ENSMUSG00000015652
	Q9UHE8
	Q9CWR7
	NM_012449
	NM_027399
	NP_036581
	NP_081675
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.^[5]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164647 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.1097-108&rft.date=1999&rft_id=info:doi/10.1101/gr.8.11.1097&rft_id=info:pmid/9847074&rft.aulast=Sanger Centre&rft.aufirst=The&rft.au=Washington University Genome Sequencing Cente, The&rft_id=https://doi.org/10.1101%2Fgr.8.11.1097&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Hubert RS, Vivanco I, Chen E, et al. (2000). "STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors". Proc. Natl. Acad. Sci. U.S.A. 96 (25): 14523–8. doi:10.1073/pnas.96.25.14523. PMC 24469. PMID 10588738.14523-8&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24469#id-name=PMC&rft_id=info:pmid/10588738&rft_id=info:doi/10.1073/pnas.96.25.14523&rft.aulast=Hubert&rft.aufirst=RS&rft.au=Vivanco, I&rft.au=Chen, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24469&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Yang D, Holt GE, Velders MP, et al. (2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice". Cancer Res. 61 (15): 5857–60. PMID 11479226.5857-60&rft.date=2001&rft_id=info:pmid/11479226&rft.aulast=Yang&rft.aufirst=D&rft.au=Holt, GE&rft.au=Velders, MP&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.36689-96&rft.date=2002&rft_id=info:doi/10.1074/jbc.M202414200&rft_id=info:pmid/12095985&rft.aulast=Korkmaz&rft.aufirst=KS&rft.au=Elbi, C&rft.au=Korkmaz, CG&rft_id=https://doi.org/10.1074%2Fjbc.M202414200&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.767-72&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961#id-name=PMC&rft_id=info:pmid/12690205&rft_id=info:doi/10.1126/science.1083423&rft_id=info:bibcode/2003Sci...300..767S&rft.aulast=Scherer&rft.aufirst=SW&rft.au=Cheung, J&rft.au=MacDonald, JR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.157-64&rft.date=2003&rft_id=info:pmid/12853948&rft_id=info:doi/10.1038/nature01782&rft_id=info:bibcode/2003Natur.424..157H&rft.aulast=Hillier&rft.aufirst=LW&rft.au=Fulton, RS&rft.au=Fulton, LA&rft_id=https://doi.org/10.1038%2Fnature01782&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">
Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes". Clin. Cancer Res. 11 (12): 4545–52. doi:10.1158/1078-0432.CCR-04-2235. PMC 1698136. PMID 15958640.4545-52&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698136#id-name=PMC&rft_id=info:pmid/15958640&rft_id=info:doi/10.1158/1078-0432.CCR-04-2235&rft.aulast=Rodeberg&rft.aufirst=DA&rft.au=Nuss, RA&rft.au=Elsawa, SF&rft.au=Celis, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698136&rfr_id=info:sid/en.wikipedia.org:STEAP1" class="Z3988">

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164647 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015652 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

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STEAP1

References

Further reading