In molecular biology, the SR1 RNA is a small RNA (sRNA) produced by species of Bacillus and closely related bacteria.[1] It is a dual-function RNA which acts both as a protein-coding RNA and as a regulatory sRNA.
SR1 RNA is involved in the regulation of arginine catabolism. SR1 RNA binds to complementary stretches of ahrC mRNA (also known as argR and inhibits translation.[2][3] AhrC endodes an arginine repressor protein which represses synthesis of arginine biosynthetic enzymes and activates arginine catabolic enzymes via regulation of the rocABC and rocDEF operons.[4][5][6]
In addition to acting as a sRNA, SR1 also encodes a small peptide, SR1P. SR1P binds to glyceraldehyde-3-phosphate dehydrogenase (GapA) and stabilises the gapA operon mRNAs.[7]
See also
editReferences
edit- ^ Gimpel M, Preis H, Barth E, Gramzow L, Brantl S (October 13, 2012). "SR1—a small RNA with two remarkably conserved functions". Nucleic Acids Research. 40 (22): 11659–11672. doi:10.1093/nar/gks895. PMC 3526287. PMID 23034808.11659-11672&rft.date=2012-10-13&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526287#id-name=PMC&rft_id=info:pmid/23034808&rft_id=info:doi/10.1093/nar/gks895&rft.aulast=Gimpel&rft.aufirst=M&rft.au=Preis, H&rft.au=Barth, E&rft.au=Gramzow, L&rft.au=Brantl, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526287&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Heidrich N, Moll I, Brantl S (2007). "In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA". Nucleic Acids Research. 35 (13): 4331–4346. doi:10.1093/nar/gkm439. PMC 1935000. PMID 17576690.4331-4346&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935000#id-name=PMC&rft_id=info:pmid/17576690&rft_id=info:doi/10.1093/nar/gkm439&rft.aulast=Heidrich&rft.aufirst=N&rft.au=Moll, I&rft.au=Brantl, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935000&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Heidrich N, Chinali A, Gerth U, Brantl S (October 2006). "The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism". Molecular Microbiology. 62 (2): 520–536. doi:10.1111/j.1365-2958.2006.05384.x. PMID 17020585.520-536&rft.date=2006-10&rft_id=info:doi/10.1111/j.1365-2958.2006.05384.x&rft_id=info:pmid/17020585&rft.aulast=Heidrich&rft.aufirst=N&rft.au=Chinali, A&rft.au=Gerth, U&rft.au=Brantl, S&rft_id=https://doi.org/10.1111%2Fj.1365-2958.2006.05384.x&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ North AK, Smith MC, Baumberg S (August 1, 1989). "Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor". Gene. 80 (1): 29–38. doi:10.1016/0378-1119(89)90247-3. PMID 2507400.29-38&rft.date=1989-08-01&rft_id=info:doi/10.1016/0378-1119(89)90247-3&rft_id=info:pmid/2507400&rft.aulast=North&rft.aufirst=AK&rft.au=Smith, MC&rft.au=Baumberg, S&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Czaplewski LG, North AK, Smith MC, Baumberg S, Stockley PG (January 1992). "Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis". Mol. Microbiol. 6 (2): 267–275. doi:10.1111/j.1365-2958.1992.tb02008.x. PMID 1312212. S2CID 3219261.267-275&rft.date=1992-01&rft_id=https://api.semanticscholar.org/CorpusID:3219261#id-name=S2CID&rft_id=info:pmid/1312212&rft_id=info:doi/10.1111/j.1365-2958.1992.tb02008.x&rft.aulast=Czaplewski&rft.aufirst=LG&rft.au=North, AK&rft.au=Smith, MC&rft.au=Baumberg, S&rft.au=Stockley, PG&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Dennis CA, Glykos NM, Parsons MR, Phillips SE (March 2002). "The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis". Acta Crystallographica Section D. 58 (Pt 3): 421–430. doi:10.1107/s0907444901021692. PMID 11856827.421-430&rft.date=2002-03&rft_id=info:doi/10.1107/s0907444901021692&rft_id=info:pmid/11856827&rft.aulast=Dennis&rft.aufirst=CA&rft.au=Glykos, NM&rft.au=Parsons, MR&rft.au=Phillips, SE&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Gimpel M, Heidrich N, Mäder U, Krügel H, Brantl S (May 2010). "A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon" (PDF). Molecular Microbiology. 76 (4): 990–1009. doi:10.1111/j.1365-2958.2010.07158.x. PMID 20444087.990-1009&rft.date=2010-05&rft_id=info:doi/10.1111/j.1365-2958.2010.07158.x&rft_id=info:pmid/20444087&rft.aulast=Gimpel&rft.aufirst=M&rft.au=Heidrich, N&rft.au=Mäder, U&rft.au=Krügel, H&rft.au=Brantl, S&rft_id=https://hal.archives-ouvertes.fr/hal-00552633/file/PEER_stage2_10.1111%252Fj.1365-2958.2010.07158.x.pdf&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Licht A, Preis S, Brantl S (October 2005). "Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis". Molecular Microbiology. 58 (1): 189–206. doi:10.1111/j.1365-2958.2005.04810.x. PMID 16164558. S2CID 29961832.189-206&rft.date=2005-10&rft_id=https://api.semanticscholar.org/CorpusID:29961832#id-name=S2CID&rft_id=info:pmid/16164558&rft_id=info:doi/10.1111/j.1365-2958.2005.04810.x&rft.aulast=Licht&rft.aufirst=A&rft.au=Preis, S&rft.au=Brantl, S&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
- ^ Licht A, Brantl S (October 2009). "The transcriptional repressor CcpN from Bacillus subtilis uses different repression mechanisms at different promoters". Journal of Biological Chemistry. 284 (44): 30032–30038. doi:10.1074/jbc.M109.033076. PMC 2781557. PMID 19726675.30032-30038&rft.date=2009-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781557#id-name=PMC&rft_id=info:pmid/19726675&rft_id=info:doi/10.1074/jbc.M109.033076&rft.aulast=Licht&rft.aufirst=A&rft.au=Brantl, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781557&rfr_id=info:sid/en.wikipedia.org:SR1 RNA" class="Z3988">
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