Wikipedia

SNX9

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.[5][6][7]

SNX9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNX9, SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDsOMIM: 605952; MGI: 1913866; HomoloGene: 49454; GeneCards: SNX9; OMA:SNX9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

51429

66616

Ensembl

ENSG00000130340

ENSMUSG00000002365

UniProt

Q9Y5X1

Q91VH2

RefSeq (mRNA)

NM_016224

NM_025664

RefSeq (protein)

NP_057308

NP_079940

Location (UCSC)Chr 6: 157.7 – 157.95 MbChr 17: 5.89 – 5.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.[7]

Interactions

edit

SNX9 has been shown to interact with ADAM9,[5] DNM2[8] and ADAM15.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130340 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002365 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Howard L; Nelson KK; Maciewicz RA; Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.31693-9&rft.date=1999-12&rft_id=info:doi/10.1074/jbc.274.44.31693&rft_id=info:pmid/10531379&rft.au=Howard L&rft.au=Nelson KK&rft.au=Maciewicz RA&rft.au=Blobel CP&rft_id=https://doi.org/10.1074%2Fjbc.274.44.31693&rfr_id=info:sid/en.wikipedia.org:SNX9" class="Z3988">
  6. ^ Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell. 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.43-56&rft.date=2007-07&rft_id=info:doi/10.1016/j.devcel.2007.04.014&rft_id=info:pmid/17609109&rft.au=Yarar D&rft.au=Waterman-Storer CM&rft.au=Schmid SL&rft_id=https://doi.org/10.1016%2Fj.devcel.2007.04.014&rfr_id=info:sid/en.wikipedia.org:SNX9" class="Z3988">
  7. ^ a b "Entrez Gene: SNX9 sorting nexin 9".
  8. ^ Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47). United States: 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949.46772-81&rft.date=2003-11&rft.issn=0021-9258&rft_id=info:pmid/12952949&rft_id=info:doi/10.1074/jbc.M307334200&rft.aulast=Lundmark&rft.aufirst=Richard&rft.au=Carlsson Sven R&rft_id=https://doi.org/10.1074%2Fjbc.M307334200&rfr_id=info:sid/en.wikipedia.org:SNX9" class="Z3988">

Further reading

edit
 

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=SNX9&oldid=1188047778"