U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[5][6]

SNRPB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNRPB2, Msl1, U2B'', small nuclear ribonucleoprotein polypeptide B2
External IDsOMIM: 603520; MGI: 104805; HomoloGene: 37728; GeneCards: SNRPB2; OMA:SNRPB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198220
NM_003092

NM_021335

RefSeq (protein)

NP_003083
NP_937863

NP_067310

Location (UCSC)Chr 20: 16.73 – 16.74 MbChr 2: 142.9 – 142.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125870Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008333Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. Bibcode:1987PNAS...84.2421H. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739.2421-5&rft.date=1987-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304663#id-name=PMC&rft_id=info:pmid/2951739&rft_id=info:doi/10.1073/pnas.84.8.2421&rft_id=info:bibcode/1987PNAS...84.2421H&rft.aulast=Habets&rft.aufirst=WJ&rft.au=Sillekens, PT&rft.au=Hoet, MH&rft.au=Schalken, JA&rft.au=Roebroek, AJ&rft.au=Leunissen, JA&rft.au=van de Ven, WJ&rft.au=van Venrooij, WJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304663&rfr_id=info:sid/en.wikipedia.org:SNRPB2" class="Z3988">
  6. ^ a b "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Further reading

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