Wikipedia

SLC23A1

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[5][6][7]

SLC23A1
Identifiers
AliasesSLC23A1, SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1
External IDsOMIM: 603790; MGI: 1341903; HomoloGene: 40769; GeneCards: SLC23A1; OMA:SLC23A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9963

20522

Ensembl

ENSG00000170482

ENSMUSG00000024354

UniProt

Q9UHI7

Q9Z2J0

RefSeq (mRNA)

NM_005847
NM_152685

NM_011397

RefSeq (protein)

NP_005838
NP_689898

NP_035527

Location (UCSC)Chr 5: 139.37 – 139.38 MbChr 18: 35.75 – 35.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024354 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.2–3&rft.pages=353-60&rft.date=1998-11&rft_id=info:doi/10.1016/S0167-4781(98)00151-1&rft_id=info:pmid/9804989&rft.aulast=Faaland&rft.aufirst=CA&rft.au=Race, JE&rft.au=Ricken, G&rft.au=Warner, FJ&rft.au=Williams, WJ&rft.au=Holtzman, EJ&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  6. ^ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na -dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.70-5&rft.date=1999-05&rft_id=info:doi/10.1038/19986&rft_id=https://api.semanticscholar.org/CorpusID:4425479#id-name=S2CID&rft_id=info:pmid/10331392&rft_id=info:bibcode/1999Natur.399...70T&rft.aulast=Tsukaguchi&rft.aufirst=H&rft.au=Tokui, T&rft.au=Mackenzie, B&rft.au=Berger, UV&rft.au=Chen, XZ&rft.au=Wang, Y&rft.au=Brubaker, RF&rft.au=Hediger, MA&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  7. ^ a b "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Further reading

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  • Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616. S2CID 22478598.87-95&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:22478598#id-name=S2CID&rft_id=info:pmid/11396616&rft_id=info:doi/10.1080/09687680110033774&rft.aulast=Liang&rft.aufirst=WJ&rft.au=Johnson, D&rft.au=Jarvis, SM&rft_id=https://doi.org/10.1080%2F09687680110033774&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Hogue DL, Ling V (July 1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.18-23&rft.date=1999-07&rft_id=info:doi/10.1006/geno.1999.5847&rft_id=info:pmid/10395795&rft.aulast=Hogue&rft.aufirst=DL&rft.au=Ling, V&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (September 1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.762-8&rft.date=1999-09&rft_id=info:doi/10.1006/bbrc.1999.1272&rft_id=info:pmid/10471399&rft.aulast=Rajan&rft.aufirst=DP&rft.au=Huang, W&rft.au=Dutta, B&rft.au=Devoe, LD&rft.au=Leibach, FH&rft.au=Ganapathy, V&rft.au=Prasad, PD&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (November 1999). "Human Na( )-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1461 (1): 1–9. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.1-9&rft.date=1999-11&rft_id=info:doi/10.1016/S0005-2736(99)00182-0&rft_id=info:pmid/10556483&rft.aulast=Wang&rft.aufirst=H&rft.au=Dutta, B&rft.au=Huang, W&rft.au=Devoe, LD&rft.au=Leibach, FH&rft.au=Ganapathy, V&rft.au=Prasad, PD&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Daruwala R, Song J, Koh WS, Rumsey SC, Levine M (November 1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521. S2CID 37936975.480-4&rft.date=1999-11&rft_id=https://api.semanticscholar.org/CorpusID:37936975#id-name=S2CID&rft_id=info:pmid/10556521&rft_id=info:doi/10.1016/S0014-5793(99)01393-9&rft.aulast=Daruwala&rft.aufirst=R&rft.au=Song, J&rft.au=Koh, WS&rft.au=Rumsey, SC&rft.au=Levine, M&rft_id=https://doi.org/10.1016%2FS0014-5793%2899%2901393-9&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (January 2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.488-94&rft.date=2000-01&rft_id=info:doi/10.1006/bbrc.1999.1929&rft_id=info:pmid/10631088&rft.aulast=Wang&rft.aufirst=Y&rft.au=Mackenzie, B&rft.au=Tsukaguchi, H&rft.au=Weremowicz, S&rft.au=Morton, CC&rft.au=Hediger, MA&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Erichsen HC, Eck P, Levine M, Chanock S (October 2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition. 131 (10): 2623–7. doi:10.1093/jn/131.10.2623. PMID 11584081.2623-7&rft.date=2001-10&rft_id=info:doi/10.1093/jn/131.10.2623&rft_id=info:pmid/11584081&rft.aulast=Erichsen&rft.aufirst=HC&rft.au=Eck, P&rft.au=Levine, M&rft.au=Chanock, S&rft_id=https://doi.org/10.1093%2Fjn%2F131.10.2623&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Hediger MA (May 2002). "New view at C". Nature Medicine. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580. S2CID 787845.445-6&rft.date=2002-05&rft_id=https://api.semanticscholar.org/CorpusID:787845#id-name=S2CID&rft_id=info:pmid/11984580&rft_id=info:doi/10.1038/nm0502-445&rft.aulast=Hediger&rft.aufirst=MA&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC (March 2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.9035-41&rft.date=2003-03&rft_id=info:doi/10.1074/jbc.M205119200&rft_id=info:pmid/12381735&rft.aulast=Maulén&rft.aufirst=NP&rft.au=Henríquez, EA&rft.au=Kempe, S&rft.au=Cárcamo, JG&rft.au=Schmid-Kotsas, A&rft.au=Bachem, M&rft.au=Grünert, A&rft.au=Bustamante, ME&rft.au=Nualart, F&rft.au=Vera, JC&rft_id=https://doi.org/10.1074%2Fjbc.M205119200&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L (December 2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology. 283 (6): C1696-704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
  • Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (August 2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.150-6&rft.date=2005-08&rft_id=info:doi/10.1016/j.bbrc.2005.06.069&rft_id=info:pmid/15993839&rft.aulast=Boyer&rft.aufirst=JC&rft.au=Campbell, CE&rft.au=Sigurdson, WJ&rft.au=Kuo, SM&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ (February 2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery". American Journal of Epidemiology. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.245-54&rft.date=2006-02&rft_id=info:doi/10.1093/aje/kwj035&rft_id=info:pmid/16357110&rft.aulast=Erichsen&rft.aufirst=HC&rft.au=Engel, SA&rft.au=Eck, PK&rft.au=Welch, R&rft.au=Yeager, M&rft.au=Levine, M&rft.au=Siega-Riz, AM&rft.au=Olshan, AF&rft.au=Chanock, SJ&rft_id=https://zenodo.org/record/1234289&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">
  • Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ (March 2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.698-706&rft.date=2007-03&rft_id=info:doi/10.1038/sj.jid.5700572&rft_id=info:pmid/17008880&rft.aulast=Kang&rft.aufirst=JS&rft.au=Kim, HN&rft.au=Jung, DJ&rft.au=Kim, JE&rft.au=Mun, GH&rft.au=Kim, YS&rft.au=Cho, D&rft.au=Shin, DH&rft.au=Hwang, YI&rft.au=Lee, WJ&rft_id=https://doi.org/10.1038%2Fsj.jid.5700572&rfr_id=info:sid/en.wikipedia.org:SLC23A1" class="Z3988">

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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