SIX4

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.

SIX4
Identifiers
Aliases	SIX4, AREC3, SIX homeobox 4
External IDs	OMIM: 606342; MGI: 106034; HomoloGene: 69089; GeneCards: SIX4; OMA:SIX4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q23.1 Start 60,709,539 bp End 60,724,351 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 73,146,383 bp End 73,160,230 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell vastus lateralis muscle Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis deltoid muscle nasal epithelium mucosa of paranasal sinus cartilage tissue parotid gland epithelium of nasopharynx Top expressed in lumbar spinal ganglion intercostal muscle maxillary prominence parotid gland utricle foot soleus muscle digastric muscle mandibular prominence lobe of prostate More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding Cellular component cytoplasm nucleus transcription regulator complex Biological process tongue development trigeminal ganglion development sarcomere organization generation of neurons regulation of branch elongation involved in ureteric bud branching negative regulation of apoptotic process positive regulation of branching involved in ureteric bud morphogenesis transcription, DNA-templated multicellular organism development negative regulation of satellite cell differentiation pharyngeal system development anatomical structure morphogenesis embryonic skeletal system morphogenesis inner ear morphogenesis myotome development fungiform papilla morphogenesis skeletal muscle fiber differentiation positive regulation of ureteric bud formation regulation of gene expression embryonic cranial skeleton morphogenesis anatomical structure development regulation of synaptic assembly at neuromuscular junction olfactory placode formation myoblast migration thymus development positive regulation of transcription, DNA-templated regulation of epithelial cell proliferation metanephric mesenchyme development male sex determination skeletal muscle tissue development negative regulation of neuron apoptotic process regulation of protein localization male sex differentiation regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II male gonad development negative regulation of transcription, DNA-templated protein localization to nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51804 20474 Ensembl ENSG00000100625 ENSMUSG00000034460 UniProt Q9UIU6 Q61321 RefSeq (mRNA) NM_017420 NM_011382 NM_001362272 RefSeq (protein) NP_059116 NP_035512 NP_001349201 Location (UCSC) Chr 14: 60.71 – 60.72 Mb Chr 12: 73.15 – 73.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
• Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
• Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development". Nucleic Acids Res. 24 (2): 303–10. doi:10.1093/nar/24.2.303. PMC 145635. PMID 8628654.