SFRS4

SRSF4
Identifiers
Aliases	SRSF4, SFRS4, SRP75, serine/arginine-rich splicing factor 4, serine and arginine rich splicing factor 4
External IDs	OMIM: 601940; MGI: 1890577; HomoloGene: 25624; GeneCards: SRSF4; OMA:SRSF4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	29,181,900 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	131,901,706 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle frontal gyrus; ; paraflocculus of cerebellum; ; ventricular zone; ; body of uterus; ; canal of the cervix; ; gastric mucosa; ; muscle layer of sigmoid colon; ; left ovary; ; right ovary;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; ascending aorta; ; aortic valve; ; primitive streak; ; ganglionic eminence; ; somite; ; mandibular prominence; ; maxillary prominence; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific mRNA binding; nucleic acid binding; protein binding; RNA binding; nucleotide binding;
Cellular component	nucleus; nucleoplasm; nuclear speck;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; negative regulation of mRNA splicing, via spliceosome; mRNA 3'-end processing; mRNA export from nucleus; RNA splicing; RNA export from nucleus; response to insulin; regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6429
	57317
	ENSG00000116350
	ENSMUSG00000028911
	Q08170
	Q8VE97
	NM_005626
	NM_020587
	NP_005617
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.^[5]^[6]

Interactions

SFRS4 has been shown to interact with Pinin.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116350 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zahler AM; Neugebauer KM; Stolk JA; Roth MB (Jul 1993). "Human SR proteins and isolation of a cDNA encoding SRp75". Mol Cell Biol. 13 (7): 4023–8. doi:10.1128/MCB.13.7.4023. PMC 359951. PMID 8321209.4023-8&rft.date=1993-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359951#id-name=PMC&rft_id=info:pmid/8321209&rft_id=info:doi/10.1128/MCB.13.7.4023&rft.au=Zahler AM&rft.au=Neugebauer KM&rft.au=Stolk JA&rft.au=Roth MB&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359951&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
^ "Entrez Gene: SFRS4 splicing factor, arginine/serine-rich 4".
^ Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391.4715-23&rft.date=2003-11&rft.issn=0146-0404&rft_id=info:pmid/14578391&rft_id=info:doi/10.1167/iovs.03-0240&rft.aulast=Zimowska&rft.aufirst=Grazyna&rft.au=Shi Jia&rft.au=Munguba Gustavo&rft.au=Jackson Moira R&rft.au=Alpatov Roman&rft.au=Simmons Matthew N&rft.au=Shi Yujiang&rft.au=Sugrue Stephen P&rft_id=https://doi.org/10.1167%2Fiovs.03-0240&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">

Zahler AM; Lane WS; Stolk JA; Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.837-47&rft.date=1992&rft_id=info:doi/10.1101/gad.6.5.837&rft_id=info:pmid/1577277&rft.au=Zahler AM&rft.au=Lane WS&rft.au=Stolk JA&rft.au=Roth MB&rft_id=https://doi.org/10.1101%2Fgad.6.5.837&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736. PMID 7651409.4898-907&rft.date=1995&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230736#id-name=PMC&rft_id=info:pmid/7651409&rft_id=info:doi/10.1128/MCB.15.9.4898&rft.aulast=Ramchatesingh&rft.aufirst=J&rft.au=Zahler, AM&rft.au=Neugebauer, KM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230736&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.au=Maruyama K&rft.au=Sugano S&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-12.678-82&rft.date=1994&rft_id=info:doi/10.1038/369678a0&rft_id=https://api.semanticscholar.org/CorpusID:4275539#id-name=S2CID&rft_id=info:pmid/8208298&rft_id=info:bibcode/1994Natur.369..678G&rft.au=Gui JF&rft.au=Lane WS&rft.au=Fu XD&rft_id=http://ir.ihb.ac.cn/handle/152342/10318&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Zhang WJ; Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC 108778. PMID 9447963.676-84&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108778#id-name=PMC&rft_id=info:pmid/9447963&rft_id=info:doi/10.1128/MCB.18.2.676&rft.au=Zhang WJ&rft.au=Wu JY&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108778&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.996-1009&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316672#id-name=PMC&rft_id=info:pmid/9531537&rft_id=info:doi/10.1101/gad.12.7.996&rft.au=Blencowe BJ&rft.au=Issner R&rft.au=Nickerson JA&rft.au=Sharp PA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316672&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.2972-80&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148514#id-name=PMC&rft_id=info:pmid/10390541&rft_id=info:doi/10.1093/nar/27.14.2972&rft.aulast=Papoutsopoulou&rft.aufirst=S&rft.au=Nikolakaki, E&rft.au=Chalepakis, G&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148514&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.307-16&rft.date=2000&rft_id=info:doi/10.1016/S1097-2765(00)50031-9&rft_id=info:pmid/10983978&rft.aulast=Monsalve&rft.aufirst=M&rft.au=Wu, Z&rft.au=Adelmant, G&rft_id=https://doi.org/10.1016%2FS1097-2765%2800%2950031-9&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Meissner M, Lopato S, Gotzmann J, et al. (2003). "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. doi:10.1016/S0014-4827(02)00046-0. PMID 12581738.184-95&rft.date=2003&rft_id=info:doi/10.1016/S0014-4827(02)50046-0&rft_id=info:pmid/12581738&rft.aulast=Meissner&rft.aufirst=M&rft.au=Lopato, S&rft.au=Gotzmann, J&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.7437-47&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC207616#id-name=PMC&rft_id=info:pmid/14559993&rft_id=info:doi/10.1128/MCB.23.21.7437-7447.2003&rft.aulast=Li&rft.aufirst=J&rft.au=Hawkins, IC&rft.au=Harvey, CD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC207616&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. PMID 14578391.4715-23&rft.date=2003&rft_id=info:doi/10.1167/iovs.03-0240&rft_id=info:pmid/14578391&rft.aulast=Zimowska&rft.aufirst=G&rft.au=Shi, J&rft.au=Munguba, G&rft_id=https://doi.org/10.1167%2Fiovs.03-0240&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.4612-24&rft.date=2004&rft_id=info:doi/10.1074/jbc.M310794200&rft_id=info:pmid/14623875&rft.aulast=de Graaf&rft.aufirst=K&rft.au=Hekerman, P&rft.au=Spelten, O&rft_id=https://doi.org/10.1074%2Fjbc.M310794200&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.94-101&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:7200157#id-name=S2CID&rft_id=info:pmid/15592455&rft_id=info:doi/10.1038/nbt1046&rft.aulast=Rush&rft.aufirst=J&rft.au=Moritz, A&rft.au=Lee, KA&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.1621-5&rft.date=2005&rft_id=info:doi/10.1126/science.1105776&rft_id=https://api.semanticscholar.org/CorpusID:39457788#id-name=S2CID&rft_id=info:pmid/15761153&rft_id=info:bibcode/2005Sci...307.1621B&rft.aulast=Barrios-Rodiles&rft.aufirst=M&rft.au=Brown, KR&rft.au=Ozdamar, B&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.315-21&rft.date=2006&rft_id=info:pmid/16710414&rft_id=info:doi/10.1038/nature04727&rft_id=info:bibcode/2006Natur.441..315G&rft.aulast=Gregory&rft.aufirst=SG&rft.au=Barlow, KF&rft.au=McLay, KE&rft_id=https://doi.org/10.1038%2Fnature04727&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116350 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8321209-5] Zahler AM; Neugebauer KM; Stolk JA; Roth MB (Jul 1993). "Human SR proteins and isolation of a cDNA encoding SRp75". Mol Cell Biol. 13 (7): 4023–8. doi:10.1128/MCB.13.7.4023. PMC 359951. PMID 8321209.4023-8&rft.date=1993-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359951#id-name=PMC&rft_id=info:pmid/8321209&rft_id=info:doi/10.1128/MCB.13.7.4023&rft.au=Zahler AM&rft.au=Neugebauer KM&rft.au=Stolk JA&rft.au=Roth MB&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359951&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">

[entrez-6] "Entrez Gene: SFRS4 splicing factor, arginine/serine-rich 4".

[pmid14578391-7] Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391.4715-23&rft.date=2003-11&rft.issn=0146-0404&rft_id=info:pmid/14578391&rft_id=info:doi/10.1167/iovs.03-0240&rft.aulast=Zimowska&rft.aufirst=Grazyna&rft.au=Shi Jia&rft.au=Munguba Gustavo&rft.au=Jackson Moira R&rft.au=Alpatov Roman&rft.au=Simmons Matthew N&rft.au=Shi Yujiang&rft.au=Sugrue Stephen P&rft_id=https://doi.org/10.1167%2Fiovs.03-0240&rfr_id=info:sid/en.wikipedia.org:SFRS4" class="Z3988">

[5]

[6]

[1]

[2]

[3]

[4]

[7]

SFRS4

Interactions

References

Further reading