SERINC1

SERINC1
Identifiers
Aliases	SERINC1, TDE1L, TDE2, TMS-2, TMS2, serine incorporator 1
External IDs	OMIM: 614548; MGI: 1926228; HomoloGene: 41334; GeneCards: SERINC1; OMA:SERINC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	122,471,807 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	57,408,626 bp
RNA expression pattern
	Top expressed in
	Pons; ; lateral nuclear group of thalamus; ; orbitofrontal cortex; ; postcentral gyrus; ; pars compacta; ; subthalamic nucleus; ; pars reticulata; ; superior vestibular nucleus; ; external globus pallidus; ; C1 segment;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; ventral tegmental area; ; medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; medial geniculate nucleus; ; subiculum; ; paraventricular nucleus of hypothalamus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; enzyme binding; protein-macromolecule adaptor activity; L-serine transmembrane transporter activity;
Cellular component	plasma membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; integral component of membrane;
Biological process	phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; positive regulation of serine C-palmitoyltransferase activity; sphingolipid metabolic process; phospholipid biosynthetic process; lipid metabolism; L-serine transport; membrane biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	57515
	56442
	ENSG00000111897
	ENSMUSG00000019877
	Q9NRX5
	Q9QZI8
	NM_020755
	NM_019760
	NP_065806
	NP_062734
	Wikidata
View/Edit Human	View/Edit Mouse

Serine incorporator 1 is a protein that in humans is encoded by the SERINC1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111897 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019877 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi:10.1242/jeb.203.3.447. hdl:10261/308420. PMID 10637174.447-57&rft.date=2000-04&rft_id=info:hdl/10261/308420&rft_id=info:pmid/10637174&rft_id=info:doi/10.1242/jeb.203.3.447&rft.aulast=Grossman&rft.aufirst=TR&rft.au=Luque, JM&rft.au=Nelson, N&rft_id=https://doi.org/10.1242%2Fjeb.203.3.447&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
^ "Entrez Gene: SERINC1 serine incorporator 1".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.805-11&rft.date=2003&rft_id=info:pmid/14574404&rft_id=info:doi/10.1038/nature02055&rft_id=info:bibcode/2003Natur.425..805M&rft.aulast=Mungall&rft.aufirst=AJ&rft.au=Palmer, SA&rft.au=Sims, SK&rft_id=https://doi.org/10.1038%2Fnature02055&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.2265-70&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697#id-name=PMC&rft_id=info:pmid/12975309&rft_id=info:doi/10.1101/gr.1293003&rft.aulast=Clark&rft.aufirst=HF&rft.au=Gurney, AL&rft.au=Abaya, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.9543-8&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16901#id-name=PMC&rft_id=info:pmid/10931946&rft_id=info:doi/10.1073/pnas.160270997&rft_id=info:bibcode/2000PNAS...97.9543H&rft.aulast=Hu&rft.aufirst=RM&rft.au=Han, ZG&rft.au=Song, HD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16901&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.337-45&rft.date=2000&rft_id=info:doi/10.1093/dnares/6.5.337&rft_id=info:pmid/10574462&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa, K&rft.au=Kikuno, R&rft_id=https://doi.org/10.1093%2Fdnares%2F6.5.337&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111897 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019877 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637174-5] Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi:10.1242/jeb.203.3.447. hdl:10261/308420. PMID 10637174.447-57&rft.date=2000-04&rft_id=info:hdl/10261/308420&rft_id=info:pmid/10637174&rft_id=info:doi/10.1242/jeb.203.3.447&rft.aulast=Grossman&rft.aufirst=TR&rft.au=Luque, JM&rft.au=Nelson, N&rft_id=https://doi.org/10.1242%2Fjeb.203.3.447&rfr_id=info:sid/en.wikipedia.org:SERINC1" class="Z3988">

[entrez-6] "Entrez Gene: SERINC1 serine incorporator 1".

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SERINC1

References

Further reading