SEC24B

SEC24B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3EH1
Identifiers
Aliases	SEC24B, SEC24, SEC24 homolog B, COPII coat complex component
External IDs	OMIM: 607184; MGI: 2139764; HomoloGene: 55968; GeneCards: SEC24B; OMA:SEC24B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	109,540,896 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,855,202 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; skin of hip; ; skin of thigh; ; retinal pigment epithelium; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; jejunal mucosa; ; germinal epithelium; ; mucosa of sigmoid colon; ; Epithelium of choroid plexus;
	Top expressed in
	genital tubercle; ; tail of embryo; ; granulocyte; ; ventricular zone; ; neural layer of retina; ; lip; ; saccule; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; zinc ion binding; metal ion binding;
Cellular component	cytoplasm; endoplasmic reticulum membrane; Golgi membrane; endoplasmic reticulum; membrane; COPII vesicle coat; cytosol; ER to Golgi transport vesicle membrane; cytoplasmic vesicle; COPII-coated ER to Golgi transport vesicle;
Biological process	lung morphogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; pulmonary artery morphogenesis; antigen processing and presentation of peptide antigen via MHC class I; regulation of establishment of planar polarity involved in neural tube closure; coronary artery morphogenesis; outflow tract morphogenesis; auditory receptor cell morphogenesis; aorta morphogenesis; auditory receptor cell stereocilium organization; neural tube closure; COPII vesicle coating; protein transport; intracellular protein transport; regulation of cargo loading into COPII-coated vesicle; lung lobe morphogenesis; cochlear nucleus development; endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle-mediated transport; COPII-coated vesicle cargo loading;
	Sources:Amigo / QuickGO
Orthologs
	10427
	99683
	ENSG00000138802
	ENSMUSG00000001052
	O95487
	n/a
	NM_001042734; NM_001300813; NM_006323; NM_001318085; NM_001318086
	NM_207209
	NP_001036199; NP_001287742; NP_001305014; NP_001305015; NP_006314
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec24B is a protein that in humans is encoded by the SEC24B gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138802 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.7833-40&rft.date=1999-04&rft_id=info:doi/10.1074/jbc.274.12.7833&rft_id=info:pmid/10075675&rft.aulast=Pagano&rft.aufirst=A&rft.au=Letourneur, F&rft.au=Garcia-Estefania, D&rft.au=Carpentier, JL&rft.au=Orci, L&rft.au=Paccaud, JP&rft_id=https://doi.org/10.1074%2Fjbc.274.12.7833&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.679-84&rft.date=1999-06&rft_id=info:doi/10.1006/bbrc.1999.0574&rft_id=info:pmid/10329445&rft.aulast=Tang&rft.aufirst=BL&rft.au=Kausalya, J&rft.au=Low, DY&rft.au=Lock, ML&rft.au=Hong, W&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
^ ^a ^b "Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae)".

Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Mol. Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.403-14&rft.date=2007&rft_id=info:doi/10.1016/j.molcel.2007.03.017&rft_id=info:pmid/17499046&rft.aulast=Mancias&rft.aufirst=JD&rft.au=Goldberg, J&rft_id=https://doi.org/10.1016%2Fj.molcel.2007.03.017&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.55-65&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129#id-name=PMC&rft_id=info:pmid/16344560&rft_id=info:doi/10.1101/gr.4039406&rft.aulast=Kimura&rft.aufirst=K&rft.au=Wakamatsu, A&rft.au=Suzuki, Y&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.591-8&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:20475874#id-name=S2CID&rft_id=info:pmid/16094384&rft_id=info:doi/10.1038/nmeth776&rft.aulast=Tao&rft.aufirst=WA&rft.au=Wollscheid, B&rft.au=O'Brien, R&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138802 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001052 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10075675-5] Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.7833-40&rft.date=1999-04&rft_id=info:doi/10.1074/jbc.274.12.7833&rft_id=info:pmid/10075675&rft.aulast=Pagano&rft.aufirst=A&rft.au=Letourneur, F&rft.au=Garcia-Estefania, D&rft.au=Carpentier, JL&rft.au=Orci, L&rft.au=Paccaud, JP&rft_id=https://doi.org/10.1074%2Fjbc.274.12.7833&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">

[pmid10329445-6] Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.679-84&rft.date=1999-06&rft_id=info:doi/10.1006/bbrc.1999.0574&rft_id=info:pmid/10329445&rft.aulast=Tang&rft.aufirst=BL&rft.au=Kausalya, J&rft.au=Low, DY&rft.au=Lock, ML&rft.au=Hong, W&rfr_id=info:sid/en.wikipedia.org:SEC24B" class="Z3988">

[entrez-7] "Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae)".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

SEC24B

References

Further reading