In enzymology, a ribitol 2-dehydrogenase (EC 1.1.1.56) is an enzyme that catalyzes the chemical reaction
| ribitol 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.56 | ||||||||
| CAS no. | 9014-23-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- ribitol NAD D-ribulose NADH H
Thus, the two substrates of this enzyme are ribitol and NAD , whereas its 3 products are D-ribulose, NADH, and H .
This enzyme participates in pentose and glucuronate interconversions.
Nomenclature
editThis enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is ribitol:NAD 2-oxidoreductase. Other names in common use include adonitol dehydrogenase, ribitol dehydrogenase A (wild type), ribitol dehydrogenase B (mutant enzyme with different properties), and ribitol dehydrogenase D (mutant enzyme with different properties).
References
edit- Hollmann S, Touster O (Mar 1957). "The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria". The Journal of Biological Chemistry. 225 (1): 87–102. PMID 13416220.87-102&rft.date=1957-03&rft_id=info:pmid/13416220&rft.aulast=Hollmann&rft.aufirst=S&rft.au=Touster, O&rfr_id=info:sid/en.wikipedia.org:Ribitol 2-dehydrogenase" class="Z3988">
- Nordlie RC, Fromm HJ (Oct 1959). "Ribitol dehydrogenase. II. Studies on the reaction mechanism". The Journal of Biological Chemistry. 234: 2523–31. PMID 14427582.2523-31&rft.date=1959-10&rft_id=info:pmid/14427582&rft.aulast=Nordlie&rft.aufirst=RC&rft.au=Fromm, HJ&rfr_id=info:sid/en.wikipedia.org:Ribitol 2-dehydrogenase" class="Z3988">
- Wood WA, McDonough MJ, Jacobs LB (Aug 1961). "Ribitol and D-arabitol utilization by Aerobacter aerogenes". The Journal of Biological Chemistry. 236: 2190–5. PMID 13786517.2190-5&rft.date=1961-08&rft_id=info:pmid/13786517&rft.aulast=Wood&rft.aufirst=WA&rft.au=McDonough, MJ&rft.au=Jacobs, LB&rfr_id=info:sid/en.wikipedia.org:Ribitol 2-dehydrogenase" class="Z3988">
