RRBP1 is a membrane-bound protein found in the endoplasmic reticulum (ER). It was originally identified as the ribosome receptor for the ER,[5] however several groups later demonstrated that this activity did not co-fractionate with RRBP1 [6][7] but rather with Sec61 (i.e. the translocon).[8][9] RRBP1 can enhance the association of certain mRNAs to the endoplasmic reticulum in a manner that does not require ribosome activity, likely by directly associating the mRNA's phosphate backbone.[10] In addition, RRBP1 may promote the association of polysomes with the translocon [11][12] and play a role in ER morphology.[13] RRBP1 may also bind to microtubules.[14] Although the p180 isoform is the most abundant, it may exist in different forms due to removal of tandem repeats by partial intraexonic splicing. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome.[4]
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^Savitz, Adam J.; Meyer, David I. (1990). "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature. 346 (6284): 540–544. Bibcode:1990Natur.346..540S. doi:10.1038/346540a0. ISSN0028-0836. PMID2165568. S2CID4353593.540-544&rft.date=1990&rft_id=https://api.semanticscholar.org/CorpusID:4353593#id-name=S2CID&rft_id=info:bibcode/1990Natur.346..540S&rft.issn=0028-0836&rft_id=info:doi/10.1038/346540a0&rft_id=info:pmid/2165568&rft.aulast=Savitz&rft.aufirst=Adam J.&rft.au=Meyer, David I.&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
^Nunnari, Jodi M.; Zimmerman, Deborah L.; Ogg, Stephen C.; Walter, Peter (1991). "Characterization of the rough endoplasmic reticulum ribosome-binding activity". Nature. 352 (6336): 638–640. Bibcode:1991Natur.352..638N. doi:10.1038/352638a0. ISSN0028-0836. PMID1650916. S2CID4364699.638-640&rft.date=1991&rft_id=https://api.semanticscholar.org/CorpusID:4364699#id-name=S2CID&rft_id=info:bibcode/1991Natur.352..638N&rft.issn=0028-0836&rft_id=info:doi/10.1038/352638a0&rft_id=info:pmid/1650916&rft.aulast=Nunnari&rft.aufirst=Jodi M.&rft.au=Zimmerman, Deborah L.&rft.au=Ogg, Stephen C.&rft.au=Walter, Peter&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
^Görlich, Dirk; Prehn, Siegfried; Hartmann, Enno; Kalies, Kai-Uwe; Rapoport, Tom A. (1992). "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation". Cell. 71 (3): 489–503. doi:10.1016/0092-8674(92)90517-G. ISSN0092-8674. PMID1423609. S2CID19078317.489-503&rft.date=1992&rft.issn=0092-8674&rft_id=https://api.semanticscholar.org/CorpusID:19078317#id-name=S2CID&rft_id=info:pmid/1423609&rft_id=info:doi/10.1016/0092-8674(92)90517-G&rft.aulast=Görlich&rft.aufirst=Dirk&rft.au=Prehn, Siegfried&rft.au=Hartmann, Enno&rft.au=Kalies, Kai-Uwe&rft.au=Rapoport, Tom A.&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
^Dejgaard, Kurt; Theberge, Jean-Francois; Heath-Engel, Hannah; Chevet, Eric; Tremblay, Michel L.; Thomas, David Y. (2010). "Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis". Journal of Proteome Research. 9 (4): 1763–1771. doi:10.1021/pr900900x. ISSN1535-3893. PMID20112977.1763-1771&rft.date=2010&rft.issn=1535-3893&rft_id=info:pmid/20112977&rft_id=info:doi/10.1021/pr900900x&rft.aulast=Dejgaard&rft.aufirst=Kurt&rft.au=Theberge, Jean-Francois&rft.au=Heath-Engel, Hannah&rft.au=Chevet, Eric&rft.au=Tremblay, Michel L.&rft.au=Thomas, David Y.&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
^Ueno, T.; Kaneko, K.; Sata, T.; Hattori, S.; Ogawa-Goto, K. (2011). "Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180". Nucleic Acids Research. 40 (7): 3006–3017. doi:10.1093/nar/gkr1197. ISSN0305-1048. PMC3326322. PMID22156060.3006-3017&rft.date=2011&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326322#id-name=PMC&rft.issn=0305-1048&rft_id=info:pmid/22156060&rft_id=info:doi/10.1093/nar/gkr1197&rft.aulast=Ueno&rft.aufirst=T.&rft.au=Kaneko, K.&rft.au=Sata, T.&rft.au=Hattori, S.&rft.au=Ogawa-Goto, K.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326322&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
^Shibata, Yoko; Shemesh, Tom; Prinz, William A.; Palazzo, Alexander F.; Kozlov, Michael M.; Rapoport, Tom A. (2010). "Mechanisms Determining the Morphology of the Peripheral ER". Cell. 143 (5): 774–788. doi:10.1016/j.cell.2010.11.007. ISSN0092-8674. PMC3008339. PMID21111237.774-788&rft.date=2010&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008339#id-name=PMC&rft.issn=0092-8674&rft_id=info:pmid/21111237&rft_id=info:doi/10.1016/j.cell.2010.11.007&rft.aulast=Shibata&rft.aufirst=Yoko&rft.au=Shemesh, Tom&rft.au=Prinz, William A.&rft.au=Palazzo, Alexander F.&rft.au=Kozlov, Michael M.&rft.au=Rapoport, Tom A.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008339&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
Savitz AJ, Meyer DI (1990). "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature. 346 (6284): 540–4. Bibcode:1990Natur.346..540S. doi:10.1038/346540a0. PMID2165568. S2CID4353593.540-4&rft.date=1990&rft_id=info:doi/10.1038/346540a0&rft_id=https://api.semanticscholar.org/CorpusID:4353593#id-name=S2CID&rft_id=info:pmid/2165568&rft_id=info:bibcode/1990Natur.346..540S&rft.aulast=Savitz&rft.aufirst=AJ&rft.au=Meyer, DI&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
Langley R, Leung E, Morris C, et al. (1998). "Identification of multiple forms of 180-kDa ribosome receptor in human cells". DNA Cell Biol. 17 (5): 449–60. doi:10.1089/dna.1998.17.449. PMID9628588.449-60&rft.date=1998&rft_id=info:doi/10.1089/dna.1998.17.449&rft_id=info:pmid/9628588&rft.aulast=Langley&rft.aufirst=R&rft.au=Leung, E&rft.au=Morris, C&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID11780052.865-71&rft.date=2002&rft_id=info:pmid/11780052&rft_id=info:doi/10.1038/414865a&rft_id=info:bibcode/2001Natur.414..865D&rft.aulast=Deloukas&rft.aufirst=P&rft.au=Matthews, LH&rft.au=Ashurst, J&rft_id=https://doi.org/10.1038%2F414865a&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243. S2CID14294292.1285-92&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:14294292#id-name=S2CID&rft_id=info:pmid/16964243&rft_id=info:doi/10.1038/nbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Villén, J&rft.au=Gerber, SA&rfr_id=info:sid/en.wikipedia.org:RRBP1" class="Z3988">
