RPH3AL

RPH3AL
Identifiers
Aliases	RPH3AL, NOC2, rabphilin 3A-like (without C2 domains), rabphilin 3A like (without C2 domains)
External IDs	OMIM: 604881; MGI: 1923492; HomoloGene: 5078; GeneCards: RPH3AL; OMA:RPH3AL - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	386,254 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,829,255 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; anterior pituitary; ; islet of Langerhans; ; right adrenal gland; ; left adrenal cortex; ; sural nerve; ; right adrenal cortex; ; right lobe of liver; ; gonad; ; right lobe of thyroid gland;
	Top expressed in
	primary oocyte; ; islet of Langerhans; ; zygote; ; epithelium of stomach; ; secondary oocyte; ; otolith organ; ; utricle; ; Pituitary Gland; ; Paneth cell; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cytoskeletal protein binding; protein binding; calcium-dependent phospholipid binding; LIM domain binding;
Cellular component	cytoplasm; secretory granule membrane; membrane; transport vesicle membrane; secretory granule; cytoplasmic vesicle; plasma membrane; intracellular anatomical structure;
Biological process	glucose homeostasis; regulation of exocytosis; positive regulation of protein secretion; intracellular protein transport; negative regulation of G protein-coupled receptor signaling pathway; exocytosis; regulation of calcium ion-dependent exocytosis; positive regulation of insulin secretion;
	Sources:Amigo / QuickGO
Orthologs
	9501
	380714
	ENSG00000181031; ENSG00000262334; ENSG00000282013
	ENSMUSG00000020847
	Q9UNE2
	Q768S4
	NM_001190411; NM_001190412; NM_001190413; NM_006987
	NM_001291159; NM_029548
	NP_001177340; NP_001177341; NP_001177342; NP_008918
	NP_001278088; NP_083824
	Wikidata
View/Edit Human	View/Edit Mouse

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.^[5]^[6]

Interactions

RPH3AL has been shown to interact with RAB27A.^[7]^[8]

References

^ ^a ^b ^c ENSG00000262334, ENSG00000282013 GRCh38: Ensembl release 89: ENSG00000181031, ENSG00000262334, ENSG00000282013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020847 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (July 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.97-101&rft.date=1999-07&rft_id=info:doi/10.1006/geno.1999.5864&rft_id=info:pmid/10395805&rft.aulast=Smith&rft.aufirst=JS&rft.au=Tachibana, I&rft.au=Allen, C&rft.au=Chiappa, SA&rft.au=Lee, HK&rft.au=McIver, B&rft.au=Jenkins, RB&rft.au=Raffel, C&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
^ "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".
^ Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Molecular Endocrinology. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.117-26&rft.date=2004-01&rft_id=info:doi/10.1210/me.2003-0300&rft_id=info:pmid/14593078&rft.aulast=Cheviet&rft.aufirst=S&rft.au=Coppola, T&rft.au=Haynes, LP&rft.au=Burgoyne, RD&rft.au=Regazzi, R&rft_id=https://doi.org/10.1210%2Fme.2003-0300&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
^ Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.15373-80&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212341200&rft_id=info:pmid/12578829&rft.aulast=Fukuda&rft.aufirst=M&rft_id=https://doi.org/10.1074%2Fjbc.M212341200&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">

Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S (November 1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells". The Journal of Biological Chemistry. 272 (47): 29407–10. doi:10.1074/jbc.272.47.29407. PMID 9367993.29407-10&rft.date=1997-11&rft_id=info:doi/10.1074/jbc.272.47.29407&rft_id=info:pmid/9367993&rft.aulast=Kotake&rft.aufirst=K&rft.au=Ozaki, N&rft.au=Mizuta, M&rft.au=Sekiya, S&rft.au=Inagaki, N&rft.au=Seino, S&rft_id=https://doi.org/10.1074%2Fjbc.272.47.29407&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (January 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984. S2CID 10177138.203-14&rft.date=2000-01&rft_id=https://api.semanticscholar.org/CorpusID:10177138#id-name=S2CID&rft_id=info:pmid/10707984&rft_id=info:doi/10.1016/S0896-6273(00)80883-1&rft.aulast=Fenster&rft.aufirst=SD&rft.au=Chung, WJ&rft.au=Zhai, R&rft.au=Cases-Langhoff, C&rft.au=Voss, B&rft.au=Garner, AM&rft.au=Kaempf, U&rft.au=Kindler, S&rft.au=Gundelfinger, ED&rft.au=Garner, CC&rft_id=https://doi.org/10.1016%2FS0896-6273%2800%2980883-1&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Haynes LP, Evans GJ, Morgan A, Burgoyne RD (March 2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2 -regulated exocytosis in neuroendocrine cells". The Journal of Biological Chemistry. 276 (13): 9726–32. doi:10.1074/jbc.M006959200. PMID 11134008.9726-32&rft.date=2001-03&rft_id=info:doi/10.1074/jbc.M006959200&rft_id=info:pmid/11134008&rft.aulast=Haynes&rft.aufirst=LP&rft.au=Evans, GJ&rft.au=Morgan, A&rft.au=Burgoyne, RD&rft_id=https://doi.org/10.1074%2Fjbc.M006959200&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Goi T, Takeuchi K, Katayama K, Hirose K, Yamaguchi A (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers". Oncology Reports. 9 (6): 1189–92. doi:10.3892/or.9.6.1189. PMID 12375017.1189-92&rft.date=2003&rft_id=info:doi/10.3892/or.9.6.1189&rft_id=info:pmid/12375017&rft.aulast=Goi&rft.aufirst=T&rft.au=Takeuchi, K&rft.au=Katayama, K&rft.au=Hirose, K&rft.au=Yamaguchi, A&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H (February 2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". The Journal of Biological Chemistry. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.4072-81&rft.date=2003-02&rft_id=info:doi/10.1074/jbc.M208898200&rft_id=info:pmid/12446671&rft.aulast=Milkereit&rft.aufirst=P&rft.au=Strauss, D&rft.au=Bassler, J&rft.au=Gadal, O&rft.au=Kühn, H&rft.au=Schütz, S&rft.au=Gas, N&rft.au=Lechner, J&rft.au=Hurt, E&rft.au=Tschochner, H&rft_id=https://doi.org/10.1074%2Fjbc.M208898200&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.15373-80&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212341200&rft_id=info:pmid/12578829&rft.aulast=Fukuda&rft.aufirst=M&rft_id=https://doi.org/10.1074%2Fjbc.M212341200&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (April 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.918-30&rft.date=2003-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180354#id-name=PMC&rft_id=info:pmid/12621583&rft_id=info:doi/10.1086/374320&rft.aulast=Cardoso&rft.aufirst=C&rft.au=Leventer, RJ&rft.au=Ward, HL&rft.au=Toyo-Oka, K&rft.au=Chung, J&rft.au=Gross, A&rft.au=Martin, CL&rft.au=Allanson, J&rft.au=Pilz, DT&rft.au=Olney, AH&rft.au=Mutchinick, OM&rft.au=Hirotsune, S&rft.au=Wynshaw-Boris, A&rft.au=Dobyns, WB&rft.au=Ledbetter, DH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180354&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Molecular Endocrinology. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.117-26&rft.date=2004-01&rft_id=info:doi/10.1210/me.2003-0300&rft_id=info:pmid/14593078&rft.aulast=Cheviet&rft.aufirst=S&rft.au=Coppola, T&rft.au=Haynes, LP&rft.au=Burgoyne, RD&rft.au=Regazzi, R&rft_id=https://doi.org/10.1210%2Fme.2003-0300&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T (March 2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells". Biochemical and Biophysical Research Communications. 316 (1): 218–25. doi:10.1016/j.bbrc.2004.02.026. PMID 15003533.218-25&rft.date=2004-03&rft_id=info:doi/10.1016/j.bbrc.2004.02.026&rft_id=info:pmid/15003533&rft.aulast=Manabe&rft.aufirst=S&rft.au=Nishimura, N&rft.au=Yamamoto, Y&rft.au=Kitamura, H&rft.au=Morimoto, S&rft.au=Imai, M&rft.au=Nagahiro, S&rft.au=Seino, S&rft.au=Sasaki, T&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.8313-8&rft.date=2004-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420391#id-name=PMC&rft_id=info:pmid/15159548&rft_id=info:doi/10.1073/pnas.0306709101&rft_id=info:bibcode/2004PNAS..101.8313M&rft.aulast=Matsumoto&rft.aufirst=M&rft.au=Miki, T&rft.au=Shibasaki, T&rft.au=Kawaguchi, M&rft.au=Shinozaki, H&rft.au=Nio, J&rft.au=Saraya, A&rft.au=Koseki, H&rft.au=Miyazaki, M&rft.au=Iwanaga, T&rft.au=Seino, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420391&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">
Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U (January 2008). "Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma". Frontiers in Bioscience. 13 (1): 1050–61. doi:10.2741/2742. PMC 2667692. PMID 17981610.1050-61&rft.date=2008-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667692#id-name=PMC&rft_id=info:pmid/17981610&rft_id=info:doi/10.2741/2742&rft.aulast=Katkoori&rft.aufirst=VR&rft.au=Jia, X&rft.au=Chatla, C&rft.au=Kumar, S&rft.au=Ponnazhagan, S&rft.au=Callens, T&rft.au=Messiaen, L&rft.au=Grizzle, WE&rft.au=Manne, U&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667692&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000262334, ENSG00000282013 GRCh38: Ensembl release 89: ENSG00000181031, ENSG00000262334, ENSG00000282013 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020847 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10395805-5] Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (July 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.97-101&rft.date=1999-07&rft_id=info:doi/10.1006/geno.1999.5864&rft_id=info:pmid/10395805&rft.aulast=Smith&rft.aufirst=JS&rft.au=Tachibana, I&rft.au=Allen, C&rft.au=Chiappa, SA&rft.au=Lee, HK&rft.au=McIver, B&rft.au=Jenkins, RB&rft.au=Raffel, C&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">

[entrez-6] "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".

[pmid14593078-7] Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Molecular Endocrinology. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.117-26&rft.date=2004-01&rft_id=info:doi/10.1210/me.2003-0300&rft_id=info:pmid/14593078&rft.aulast=Cheviet&rft.aufirst=S&rft.au=Coppola, T&rft.au=Haynes, LP&rft.au=Burgoyne, RD&rft.au=Regazzi, R&rft_id=https://doi.org/10.1210%2Fme.2003-0300&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">

[pmid12578829-8] Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.15373-80&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212341200&rft_id=info:pmid/12578829&rft.aulast=Fukuda&rft.aufirst=M&rft_id=https://doi.org/10.1074%2Fjbc.M212341200&rfr_id=info:sid/en.wikipedia.org:RPH3AL" class="Z3988">

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]

RPH3AL

Interactions

References

Further reading