Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.[5]

RNH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNH1, RAI, RNH, ribonuclease/angiogenin inhibitor 1
External IDsOMIM: 173320; MGI: 1195456; HomoloGene: 2204; GeneCards: RNH1; OMA:RNH1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172100
NM_001172101
NM_145135

RefSeq (protein)

NP_001165571
NP_001165572
NP_660117

Location (UCSC)Chr 11: 0.49 – 0.51 MbChr 7: 140.74 – 140.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038650Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".

Further reading

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  • Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization". Genomics. 8 (1): 175–8. doi:10.1016/0888-7543(90)90242-M. PMID 2081593.175-8&rft.date=1991&rft_id=info:doi/10.1016/0888-7543(90)90242-M&rft_id=info:pmid/2081593&rft.aulast=Zneimer&rft.aufirst=SM&rft.au=Crawford, D&rft.au=Schneider, NR&rft.au=Beutler, B&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5". Genomics. 8 (4): 717–21. doi:10.1016/0888-7543(90)90260-2. PMID 2276743.717-21&rft.date=1991&rft_id=info:doi/10.1016/0888-7543(90)90260-2&rft_id=info:pmid/2276743&rft.aulast=Weremowicz&rft.aufirst=S&rft.au=Fox, EA&rft.au=Morton, CC&rft.au=Vallee, BL&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin". Biochemistry. 28 (8): 3556–61. doi:10.1021/bi00434a061. PMID 2742853.3556-61&rft.date=1989&rft_id=info:doi/10.1021/bi00434a061&rft_id=info:pmid/2742853&rft.aulast=Lee&rft.aufirst=FS&rft.au=Vallee, BL&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay". Biochemistry. 27 (17): 6282–7. doi:10.1021/bi00417a013. PMID 3064806.6282-7&rft.date=1989&rft_id=info:doi/10.1021/bi00417a013&rft_id=info:pmid/3064806&rft.aulast=Bond&rft.aufirst=MD&rft.au=Vallee, BL&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats". Biochemistry. 27 (23): 8537–44. doi:10.1021/bi00423a006. PMID 3219361.8537-44&rft.date=1989&rft_id=info:doi/10.1021/bi00423a006&rft_id=info:pmid/3219361&rft.aulast=Hofsteenge&rft.aufirst=J&rft.au=Kieffer, B&rft.au=Matthies, R&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor". Biochemistry. 27 (23): 8545–53. doi:10.1021/bi00423a007. PMID 3219362.8545-53&rft.date=1989&rft_id=info:doi/10.1021/bi00423a007&rft_id=info:pmid/3219362&rft.aulast=Lee&rft.aufirst=FS&rft.au=Fox, EA&rft.au=Zhou, HM&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module". EMBO J. 7 (13): 4151–6. doi:10.1002/j.1460-2075.1988.tb03310.x. PMC 455125. PMID 3243277.4151-6&rft.date=1989&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC455125#id-name=PMC&rft_id=info:pmid/3243277&rft_id=info:doi/10.1002/j.1460-2075.1988.tb03310.x&rft.aulast=Schneider&rft.aufirst=R&rft.au=Schneider-Scherzer, E&rft.au=Thurnher, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC455125&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. Bibcode:1987PNAS...84.2238S. doi:10.1073/pnas.84.8.2238. PMC 304624. PMID 3470787.2238-41&rft.date=1987&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304624#id-name=PMC&rft_id=info:pmid/3470787&rft_id=info:doi/10.1073/pnas.84.8.2238&rft_id=info:bibcode/1987PNAS...84.2238S&rft.aulast=Shapiro&rft.aufirst=R&rft.au=Vallee, BL&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304624&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas". Gastroenterol. Jpn. 18 (5): 468–73. doi:10.1007/BF02776587. PMID 6653993. S2CID 10963236.468-73&rft.date=1984&rft_id=https://api.semanticscholar.org/CorpusID:10963236#id-name=S2CID&rft_id=info:pmid/6653993&rft_id=info:doi/10.1007/BF02776587&rft.aulast=Kiyohara&rft.aufirst=H&rft.au=Menjo, M&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.421-8&rft.date=1994&rft_id=info:doi/10.1006/abbi.1994.1328&rft_id=info:pmid/8037455&rft.aulast=Nadano&rft.aufirst=D&rft.au=Yasuda, T&rft.au=Takeshita, H&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats". Nature. 366 (6457): 751–6. doi:10.1038/366751a0. PMID 8264799. S2CID 34579479.751-6&rft.date=1994&rft_id=https://api.semanticscholar.org/CorpusID:34579479#id-name=S2CID&rft_id=info:pmid/8264799&rft_id=info:doi/10.1038/366751a0&rft.aulast=Kobe&rft.aufirst=B&rft.au=Deisenhofer, J&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.5162-77&rft.date=1997&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170149#id-name=PMC&rft_id=info:pmid/9311977&rft_id=info:doi/10.1093/emboj/16.17.5162&rft.aulast=Papageorgiou&rft.aufirst=AC&rft.au=Shapiro, R&rft.au=Acharya, KR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170149&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.24978-84&rft.date=2001&rft_id=info:doi/10.1074/jbc.M102440200&rft_id=info:pmid/11342552&rft.aulast=Gaur&rft.aufirst=D&rft.au=Swaminathan, S&rft.au=Batra, JK&rft_id=https://doi.org/10.1074%2Fjbc.M102440200&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.268-75&rft.date=2005&rft_id=info:doi/10.1038/sj.cgt.7700742&rft_id=info:pmid/15592448&rft.aulast=Fu&rft.aufirst=P&rft.au=Chen, J&rft.au=Tian, Y&rft_id=https://doi.org/10.1038%2Fsj.cgt.7700742&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.637-55&rft.date=2005&rft_id=info:doi/10.1016/j.jmb.2005.01.035&rft_id=info:pmid/15755456&rft.aulast=Iyer&rft.aufirst=S&rft.au=Holloway, DE&rft.au=Kumar, K&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">
  • Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMC 1993901. PMID 17350650.434-49&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993901#id-name=PMC&rft_id=info:pmid/17350650&rft_id=info:doi/10.1016/j.jmb.2007.02.005&rft.aulast=Johnson&rft.aufirst=RJ&rft.au=McCoy, JG&rft.au=Bingman, CA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993901&rfr_id=info:sid/en.wikipedia.org:RNH1" class="Z3988">