Wikipedia

RNASE1

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[5][6]

RNASE1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
External IDsOMIM: 180440; MGI: 97919; HomoloGene: 7919; GeneCards: RNASE1; OMA:RNASE1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6035

19752

Ensembl

ENSG00000129538

ENSMUSG00000035896

UniProt

P07998

P00683
Q8C6G3

RefSeq (mRNA)

NM_198235
NM_002933
NM_198232
NM_198234

NM_011271

RefSeq (protein)

NP_002924
NP_937875
NP_937877
NP_937878

NP_035401

Location (UCSC)Chr 14: 20.8 – 20.8 MbChr 14: 51.38 – 51.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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According to the US National Library of Medicine, "This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA." Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129538 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035896 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia. 21 (9): 691–4. PMID 8588814.691-4&rft.date=1995-09&rft_id=info:pmid/8588814&rft.aulast=Kochetov&rft.aufirst=AV&rft.au=Lukasheva, VV&rft.au=Filipenko, ML&rft.au=Mertvetsov, NP&rft.au=Rivkin, MI&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  6. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)".

Further reading

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  • Nogués MV, Vilanova M, Cuchillo CM (Nov 1995). "Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1253 (1): 16–24. doi:10.1016/0167-4838(95)00138-k. PMID 7492863.16-24&rft.date=1995-11&rft_id=info:doi/10.1016/0167-4838(95)00138-k&rft_id=info:pmid/7492863&rft.aulast=Nogués&rft.aufirst=MV&rft.au=Vilanova, M&rft.au=Cuchillo, CM&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Schienman JE, Holt RA, Auerbach MR, Stewart CB (Aug 2006). "Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys". Molecular Biology and Evolution. 23 (8): 1465–79. doi:10.1093/molbev/msl025. PMID 16751256.1465-79&rft.date=2006-08&rft_id=info:doi/10.1093/molbev/msl025&rft_id=info:pmid/16751256&rft.aulast=Schienman&rft.aufirst=JE&rft.au=Holt, RA&rft.au=Auerbach, MR&rft.au=Stewart, CB&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Sakakibara R, Hashida K, Kitahara T, Ishiguro M (Mar 1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women". Journal of Biochemistry. 111 (3): 325–30. doi:10.1093/oxfordjournals.jbchem.a123757. PMID 1587793.325-30&rft.date=1992-03&rft_id=info:doi/10.1093/oxfordjournals.jbchem.a123757&rft_id=info:pmid/1587793&rft.aulast=Sakakibara&rft.aufirst=R&rft.au=Hashida, K&rft.au=Kitahara, T&rft.au=Ishiguro, M&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Haugg M, Schein CH (Feb 1992). "The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR)". Nucleic Acids Research. 20 (3): 612. doi:10.1093/nar/20.3.612. PMC 310435. PMID 1741299.
  • Sakakibara R, Hashida K, Tominaga N, Sakai K, Ishiguro M, Imamura S, Ohmatsu F, Sato E (Jan 1991). "A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease". Chemical & Pharmaceutical Bulletin. 39 (1): 146–9. doi:10.1248/cpb.39.146. PMID 2049798.146-9&rft.date=1991-01&rft_id=info:doi/10.1248/cpb.39.146&rft_id=info:pmid/2049798&rft.aulast=Sakakibara&rft.aufirst=R&rft.au=Hashida, K&rft.au=Tominaga, N&rft.au=Sakai, K&rft.au=Ishiguro, M&rft.au=Imamura, S&rft.au=Ohmatsu, F&rft.au=Sato, E&rft_id=https://doi.org/10.1248%2Fcpb.39.146&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Mizuta K, Awazu S, Yasuda T, Kishi K (Aug 1990). "Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases". Archives of Biochemistry and Biophysics. 281 (1): 144–51. doi:10.1016/0003-9861(90)90424-W. PMID 2383019.144-51&rft.date=1990-08&rft_id=info:doi/10.1016/0003-9861(90)90424-W&rft_id=info:pmid/2383019&rft.aulast=Mizuta&rft.aufirst=K&rft.au=Awazu, S&rft.au=Yasuda, T&rft.au=Kishi, K&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Beintema JJ, Blank A, Schieven GL, Dekker CA, Sorrentino S, Libonati M (Oct 1988). "Differences in glycosylation pattern of human secretory ribonucleases". The Biochemical Journal. 255 (2): 501–5. PMC 1135256. PMID 3202829.501-5&rft.date=1988-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135256#id-name=PMC&rft_id=info:pmid/3202829&rft.aulast=Beintema&rft.aufirst=JJ&rft.au=Blank, A&rft.au=Schieven, GL&rft.au=Dekker, CA&rft.au=Sorrentino, S&rft.au=Libonati, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135256&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Beintema JJ, Wietzes P, Weickmann JL, Glitz DG (Jan 1984). "The amino acid sequence of human pancreatic ribonuclease". Analytical Biochemistry. 136 (1): 48–64. doi:10.1016/0003-2697(84)90306-3. PMID 6201087.48-64&rft.date=1984-01&rft_id=info:doi/10.1016/0003-2697(84)90306-3&rft_id=info:pmid/6201087&rft.aulast=Beintema&rft.aufirst=JJ&rft.au=Wietzes, P&rft.au=Weickmann, JL&rft.au=Glitz, DG&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Russo N, de Nigris M, Ciardiello A, Di Donato A, D'Alessio G (Aug 1995). "Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease". FEBS Letters. 369 (2–3): 352. doi:10.1016/0014-5793(95)96890-G. PMID 7649283. S2CID 45739736.2–3&rft.pages=352&rft.date=1995-08&rft_id=https://api.semanticscholar.org/CorpusID:45739736#id-name=S2CID&rft_id=info:pmid/7649283&rft_id=info:doi/10.1016/0014-5793(95)96890-G&rft.aulast=Russo&rft.aufirst=N&rft.au=de Nigris, M&rft.au=Ciardiello, A&rft.au=Di Donato, A&rft.au=D'Alessio, G&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Seno M, Futami J, Kosaka M, Seno S, Yamada H (Aug 1994). "Nucleotide sequence encoding human pancreatic ribonuclease". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1218 (3): 466–8. doi:10.1016/0167-4781(94)90208-9. PMID 8049276.466-8&rft.date=1994-08&rft_id=info:doi/10.1016/0167-4781(94)90208-9&rft_id=info:pmid/8049276&rft.aulast=Seno&rft.aufirst=M&rft.au=Futami, J&rft.au=Kosaka, M&rft.au=Seno, S&rft.au=Yamada, H&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Yasuda T, Nadano D, Takeshita H, Kishi K (Dec 1993). "Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases". The Biochemical Journal. 296 (3): 617–25. doi:10.1042/bj2960617. PMC 1137742. PMID 8280059.617-25&rft.date=1993-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137742#id-name=PMC&rft_id=info:pmid/8280059&rft_id=info:doi/10.1042/bj2960617&rft.aulast=Yasuda&rft.aufirst=T&rft.au=Nadano, D&rft.au=Takeshita, H&rft.au=Kishi, K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137742&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Papageorgiou AC, Shapiro R, Acharya KR (Sep 1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". The EMBO Journal. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.5162-77&rft.date=1997-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170149#id-name=PMC&rft_id=info:pmid/9311977&rft_id=info:doi/10.1093/emboj/16.17.5162&rft.aulast=Papageorgiou&rft.aufirst=AC&rft.au=Shapiro, R&rft.au=Acharya, KR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170149&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Klink TA, Woycechowsky KJ, Taylor KM, Raines RT (Jan 2000). "Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A". European Journal of Biochemistry. 267 (2): 566–72. doi:10.1046/j.1432-1327.2000.01037.x. PMID 10632727.566-72&rft.date=2000-01&rft_id=info:doi/10.1046/j.1432-1327.2000.01037.x&rft_id=info:pmid/10632727&rft.aulast=Klink&rft.aufirst=TA&rft.au=Woycechowsky, KJ&rft.au=Taylor, KM&rft.au=Raines, RT&rft_id=https://doi.org/10.1046%2Fj.1432-1327.2000.01037.x&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M (Oct 2000). "Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases". Journal of Molecular Biology. 303 (1): 49–60. doi:10.1006/jmbi.2000.4506. PMID 11021969.49-60&rft.date=2000-10&rft_id=info:doi/10.1006/jmbi.2000.4506&rft_id=info:pmid/11021969&rft.aulast=Pous&rft.aufirst=J&rft.au=Canals, A&rft.au=Terzyan, SS&rft.au=Guasch, A&rft.au=Benito, A&rft.au=Ribó, M&rft.au=Vilanova, M&rft.au=Coll, M&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M (Apr 2001). "Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution" (PDF). Acta Crystallographica Section D. 57 (Pt 4): 498–505. Bibcode:2001AcCrD..57..498P. doi:10.1107/S0907444901001147. PMID 11264578.498-505&rft.date=2001-04&rft_id=info:pmid/11264578&rft_id=info:doi/10.1107/S0907444901001147&rft_id=info:bibcode/2001AcCrD..57..498P&rft.aulast=Pous&rft.aufirst=J&rft.au=Mallorquí-Fernández, G&rft.au=Peracaula, R&rft.au=Terzyan, SS&rft.au=Futami, J&rft.au=Tada, H&rft.au=Yamada, H&rft.au=Seno, M&rft.au=de Llorens, R&rft.au=Gomis-Rüth, FX&rft.au=Coll, M&rft_id=http://journals.iucr.org/d/issues/2001/04/00/li0374/li0374.pdf&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Gaur D, Swaminathan S, Batra JK (Jul 2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". The Journal of Biological Chemistry. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.24978-84&rft.date=2001-07&rft_id=info:doi/10.1074/jbc.M102440200&rft_id=info:pmid/11342552&rft.aulast=Gaur&rft.aufirst=D&rft.au=Swaminathan, S&rft.au=Batra, JK&rft_id=https://doi.org/10.1074%2Fjbc.M102440200&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Futami J, Maeda T, Kitazoe M, Nukui E, Tada H, Seno M, Kosaka M, Yamada H (Jun 2001). "Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups". Biochemistry. 40 (25): 7518–24. doi:10.1021/bi010248g. PMID 11412105.7518-24&rft.date=2001-06&rft_id=info:doi/10.1021/bi010248g&rft_id=info:pmid/11412105&rft.aulast=Futami&rft.aufirst=J&rft.au=Maeda, T&rft.au=Kitazoe, M&rft.au=Nukui, E&rft.au=Tada, H&rft.au=Seno, M&rft.au=Kosaka, M&rft.au=Yamada, H&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
  • Canals A, Pous J, Guasch A, Benito A, Ribó M, Vilanova M, Coll M (Oct 2001). "The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization". Structure. 9 (10): 967–76. doi:10.1016/S0969-2126(01)00659-1. PMID 11591351.967-76&rft.date=2001-10&rft_id=info:doi/10.1016/S0969-2126(01)00659-1&rft_id=info:pmid/11591351&rft.aulast=Canals&rft.aufirst=A&rft.au=Pous, J&rft.au=Guasch, A&rft.au=Benito, A&rft.au=Ribó, M&rft.au=Vilanova, M&rft.au=Coll, M&rft_id=https://doi.org/10.1016%2FS0969-2126%2801%2900659-1&rfr_id=info:sid/en.wikipedia.org:RNASE1" class="Z3988">
edit
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribonuclease pancreatic


 

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