Wikipedia

RGS20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[5][6][7]

RGS20
Identifiers
AliasesRGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDsOMIM: 607193; MGI: 1929866; HomoloGene: 2745; GeneCards: RGS20; OMA:RGS20 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8601

58175

Ensembl

ENSG00000147509

ENSMUSG00000002459

UniProt

O76081

Q9QZB1

RefSeq (mRNA)

NM_001286673
NM_001286674
NM_001286675
NM_003702
NM_170587

NM_001177795
NM_001290372
NM_021374

RefSeq (protein)

NP_001273602
NP_001273603
NP_001273604
NP_003693
NP_733466

NP_001171266
NP_001277301
NP_067349

Location (UCSC)Chr 8: 53.85 – 53.96 MbChr 1: 4.98 – 5.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][7]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[8]

Interactions

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RGS20 has been shown to interact with GNAO1[9] and GNAZ.[5][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147509 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002459 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". The Journal of Biological Chemistry. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279.26008-13&rft.date=1998-10&rft_id=info:doi/10.1074/jbc.273.40.26008&rft_id=info:pmid/9748279&rft.aulast=Glick&rft.aufirst=JL&rft.au=Meigs, TE&rft.au=Miron, A&rft.au=Casey, PJ&rft_id=https://doi.org/10.1074%2Fjbc.273.40.26008&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  6. ^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (October 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". The Journal of Biological Chemistry. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280.26014-25&rft.date=1998-10&rft_id=info:doi/10.1074/jbc.273.40.26014&rft_id=info:pmid/9748280&rft.aulast=Wang&rft.aufirst=J&rft.au=Ducret, A&rft.au=Tu, Y&rft.au=Kozasa, T&rft.au=Aebersold, R&rft.au=Ross, EM&rft_id=https://doi.org/10.1074%2Fjbc.273.40.26014&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  7. ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.665-76&rft.date=2008-12&rft_id=https://api.semanticscholar.org/CorpusID:24698373#id-name=S2CID&rft_id=info:pmid/19067971&rft_id=info:doi/10.1111/j.1755-148X.2008.00505.x&rft.aulast=Hoek&rft.aufirst=KS&rft.au=Schlegel, NC&rft.au=Eichhoff, OM&rft.au=Widmer, DS&rft.au=Praetorius, C&rft.au=Einarsson, SO&rft.au=Valgeirsdottir, S&rft.au=Bergsteinsdottir, K&rft.au=Schepsky, A&rft.au=Dummer, R&rft.au=Steingrimsson, E&rft_id=https://doi.org/10.1111%2Fj.1755-148X.2008.00505.x&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  9. ^ Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (June 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cellular Signalling. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. PMC 3107604. PMID 18407463.1190-7&rft.date=2008-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107604#id-name=PMC&rft_id=info:pmid/18407463&rft_id=info:doi/10.1016/j.cellsig.2008.02.008&rft.aulast=Pagano&rft.aufirst=M&rft.au=Jordan, JD&rft.au=Neves, SR&rft.au=Nguyen, T&rft.au=Iyengar, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107604&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  10. ^ Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. PMID 12414994.4483-93&rft.date=2002-12&rft_id=info:doi/10.1242/jcs.00093&rft_id=info:pmid/12414994&rft.aulast=Nagahama&rft.aufirst=M&rft.au=Usui, S&rft.au=Shinohara, T&rft.au=Yamaguchi, T&rft.au=Tani, K&rft.au=Tagaya, M&rft_id=https://doi.org/10.1242%2Fjcs.00093&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">

Further reading

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  • Barker SA, Wang J, Sierra DA, Ross EM (December 2001). "RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20". Genomics. 78 (3): 223–9. doi:10.1006/geno.2001.6659. PMID 11735229.223-9&rft.date=2001-12&rft_id=info:doi/10.1006/geno.2001.6659&rft_id=info:pmid/11735229&rft.aulast=Barker&rft.aufirst=SA&rft.au=Wang, J&rft.au=Sierra, DA&rft.au=Ross, EM&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.177-85&rft.date=2002-02&rft_id=https://api.semanticscholar.org/CorpusID:16065132#id-name=S2CID&rft_id=info:pmid/11829488&rft_id=info:doi/10.1006/geno.2002.6693&rft.aulast=Sierra&rft.aufirst=DA&rft.au=Gilbert, DJ&rft.au=Householder, D&rft.au=Grishin, NV&rft.au=Yu, K&rft.au=Ukidwe, P&rft.au=Barker, SA&rft.au=He, W&rft.au=Wensel, TG&rft.au=Otero, G&rft.au=Brown, G&rft.au=Copeland, NG&rft.au=Jenkins, NA&rft.au=Wilkie, TM&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". The Journal of Biological Chemistry. 277 (20): 18127–33. doi:10.1074/jbc.M201065200. PMID 11882662.18127-33&rft.date=2002-05&rft_id=info:doi/10.1074/jbc.M201065200&rft_id=info:pmid/11882662&rft.aulast=Nixon&rft.aufirst=AB&rft.au=Grenningloh, G&rft.au=Casey, PJ&rft_id=https://doi.org/10.1074%2Fjbc.M201065200&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Wang Y, Ho G, Zhang JJ, Nieuwenhuijsen B, Edris W, Chanda PK, Young KH (December 2002). "Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling". The Journal of Biological Chemistry. 277 (50): 48325–32. doi:10.1074/jbc.M206116200. PMID 12379657.48325-32&rft.date=2002-12&rft_id=info:doi/10.1074/jbc.M206116200&rft_id=info:pmid/12379657&rft.aulast=Wang&rft.aufirst=Y&rft.au=Ho, G&rft.au=Zhang, JJ&rft.au=Nieuwenhuijsen, B&rft.au=Edris, W&rft.au=Chanda, PK&rft.au=Young, KH&rft_id=https://doi.org/10.1074%2Fjbc.M206116200&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. PMID 12414994.4483-93&rft.date=2002-12&rft_id=info:doi/10.1242/jcs.00093&rft_id=info:pmid/12414994&rft.aulast=Nagahama&rft.aufirst=M&rft.au=Usui, S&rft.au=Shinohara, T&rft.au=Yamaguchi, T&rft.au=Tani, K&rft.au=Tagaya, M&rft_id=https://doi.org/10.1242%2Fjcs.00093&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Fischer T, De Vries L, Meerloo T, Farquhar MG (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi:10.1073/pnas.1432965100. PMC 166218. PMID 12826607.8270-5&rft.date=2003-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166218#id-name=PMC&rft_id=info:pmid/12826607&rft_id=info:doi/10.1073/pnas.1432965100&rft_id=info:bibcode/2003PNAS..100.8270F&rft.aulast=Fischer&rft.aufirst=T&rft.au=De Vries, L&rft.au=Meerloo, T&rft.au=Farquhar, MG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166218&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Xu GY, Hum WT, Sukits SF, Hsiao CL, Liu Y, Malakian K, et al. (April 2004). "1H, 13C and 15N resonance assignments of human RGSZ1". Journal of Biomolecular NMR. 28 (4): 409–10. doi:10.1023/B:JNMR.0000015374.29659.f9. PMID 14872136. S2CID 48639960.409-10&rft.date=2004-04&rft_id=https://api.semanticscholar.org/CorpusID:48639960#id-name=S2CID&rft_id=info:pmid/14872136&rft_id=info:doi/10.1023/B:JNMR.0000015374.29659.f9&rft.aulast=Xu&rft.aufirst=GY&rft.au=Hum, WT&rft.au=Sukits, SF&rft.au=Hsiao, CL&rft.au=Liu, Y&rft.au=Malakian, K&rft.au=Monteiro, K&rft.au=Wolfrom, S&rft.au=Wang, Y&rft.au=Young, KH&rft.au=Moy, FJ&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH (April 2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cellular Signalling. 19 (4): 723–30. doi:10.1016/j.cellsig.2006.09.008. PMID 17126529.723-30&rft.date=2007-04&rft_id=info:doi/10.1016/j.cellsig.2006.09.008&rft_id=info:pmid/17126529&rft.aulast=Ajit&rft.aufirst=SK&rft.au=Ramineni, S&rft.au=Edris, W&rft.au=Hunt, RA&rft.au=Hum, WT&rft.au=Hepler, JR&rft.au=Young, KH&rfr_id=info:sid/en.wikipedia.org:RGS20" class="Z3988">
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


 

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