REXO2

REX2, RNA exonuclease 2 homolog (S. cerevisiae), also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.

REXO2
Identifiers
Aliases	REXO2, REX2, RFN, SFN, CGI-114, RNA exonuclease 2
External IDs	OMIM: 607149; MGI: 1888981; HomoloGene: 6447; GeneCards: REXO2; OMA:REXO2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.2 Start 114,439,435 bp End 114,450,279 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.3 Start 48,379,812 bp End 48,391,923 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte decidua Achilles tendon stromal cell of endometrium right ventricle smooth muscle tissue vena cava saphenous vein parotid gland kidney tubule Top expressed in lacrimal gland ascending aorta hair follicle yolk sac aortic valve molar salivary gland endothelial cell of lymphatic vessel submandibular gland parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity exonuclease activity hydrolase activity 3'-5' exonuclease activity nucleic acid binding 3'-5'-exoribonuclease activity Cellular component cytoplasm mitochondrial matrix mitochondrial intermembrane space nucleolus nucleus focal adhesion mitochondrion Biological process nucleobase-containing compound metabolic process nucleotide metabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25996 104444 Ensembl ENSG00000076043 ENSMUSG00000032026 UniProt Q9Y3B8 Q9D8S4 RefSeq (mRNA) NM_015523 NM_024233 NM_001357501 NM_001357503 NM_001357505 RefSeq (protein) NP_056338 NP_077195 NP_001344430 NP_001344432 NP_001344434 Location (UCSC) Chr 11: 114.44 – 114.45 Mb Chr 9: 48.38 – 48.39 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mono-nucleotides in a sequential manner.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Nguyen LH, Erzberger JP, Root J, Wilson DM (2000). "The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers". J. Biol. Chem. 275 (34): 25900–6. doi:10.1074/jbc.M002672200. PMID 10851236.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ito S, Kita K, Zhai L, et al. (2006). "Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death". Photochem. Photobiol. 80 (2): 281–5. doi:10.1562/2004-01-21-RA-051. PMID 15362935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.