Wikipedia

RBM3

Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.[4][5]

RBM3
Identifiers
AliasesRBM3, IS1-RNPL, RNPL, RNA binding motif (RNP1, RRM) protein 3, RNA binding motif protein 3
External IDsOMIM: 300027; MGI: 3642874; HomoloGene: 31404; GeneCards: RBM3; OMA:RBM3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5935

100043257

Ensembl

ENSG00000102317

n/a

UniProt

P98179

n/a

RefSeq (mRNA)

NM_001017430
NM_001017431
NM_006743

XM_036156140

RefSeq (protein)

NP_006734

n/a

Location (UCSC)Chr X: 48.57 – 48.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5] RBM3 contains a poison exon whose inclusion is lowered during hypothermia.[6]

RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[7] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[8] and based on confocal microscopy mainly localised to the nucleoplasm.[9]

Clinical significance

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RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[7] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102317 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–11. doi:10.1093/hmg/4.12.2307. PMID 8634703.2307-11&rft.date=1995-12&rft_id=info:doi/10.1093/hmg/4.12.2307&rft_id=info:pmid/8634703&rft.aulast=Derry&rft.aufirst=JM&rft.au=Kerns, JA&rft.au=Francke, U&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  5. ^ a b "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
  6. ^ Lin, Julie Qiaojin; Khuperkar, Deepak; Pavlou, Sofia; Makarchuk, Stanislaw; Patikas, Nikolaos; Lee, Flora CY; Zbiegly, Julia M; Kang, Jianning; Field, Sarah F; Bailey, David MD; Freeman, Joshua L; Ule, Jernej; Metzakopian, Emmanouil; Ruepp, Marc‐David; Mallucci, Giovanna R (2023-07-17). "HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion". The EMBO Journal. 42 (14). doi:10.15252/embj.2022113168. ISSN 0261-4189.
  7. ^ a b Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.22235-22250&rft.date=2017-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400660#id-name=PMC&rft_id=info:pmid/28118608&rft_id=info:doi/10.18632/oncotarget.14755&rft.aulast=Zhou&rft.aufirst=RB&rft.au=Lu, XL&rft.au=Zhang, CY&rft.au=Yin, DC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400660&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  8. ^ "Tissue expression of RBM3 - Summary". The Human Protein Atlas.
  9. ^ "Cell atlas - RBM3". The Human Protein Atlas.
  10. ^ "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

Further reading

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  • Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress". Biochemical and Biophysical Research Communications. 236 (3): 804–7. doi:10.1006/bbrc.1997.7059. PMID 9245737.804-7&rft.date=1997-07&rft_id=info:doi/10.1006/bbrc.1997.7059&rft_id=info:pmid/9245737&rft.aulast=Danno&rft.aufirst=S&rft.au=Nishiyama, H&rft.au=Higashitsuji, H&rft.au=Yokoi, H&rft.au=Xue, JH&rft.au=Itoh, K&rft.au=Matsuda, T&rft.au=Fujita, J&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Chappell SA, Mauro VP (September 2003). "The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements". The Journal of Biological Chemistry. 278 (36): 33793–800. doi:10.1074/jbc.M303495200. PMID 12824175.33793-800&rft.date=2003-09&rft_id=info:doi/10.1074/jbc.M303495200&rft_id=info:pmid/12824175&rft.aulast=Chappell&rft.aufirst=SA&rft.au=Mauro, VP&rft_id=https://doi.org/10.1074%2Fjbc.M303495200&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–94. doi:10.1242/jcs.01026. PMID 15075239.1785-94&rft.date=2004-04&rft_id=info:doi/10.1242/jcs.01026&rft_id=info:pmid/15075239&rft.aulast=Wellmann&rft.aufirst=S&rft.au=Bührer, C&rft.au=Moderegger, E&rft.au=Zelmer, A&rft.au=Kirschner, R&rft.au=Koehne, P&rft.au=Fujita, J&rft.au=Seeger, K&rft_id=https://doi.org/10.1242%2Fjcs.01026&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.2763-72&rft.date=2004-05&rft_id=info:doi/10.1021/ac035352d&rft_id=info:pmid/15144186&rft.aulast=Brill&rft.aufirst=LM&rft.au=Salomon, AR&rft.au=Ficarro, SB&rft.au=Mukherji, M&rft.au=Stettler-Gill, M&rft.au=Peters, EC&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors". Virology. 329 (2): 328–36. doi:10.1016/j.virol.2004.08.017. hdl:10161/15063. PMID 15518812.328-36&rft.date=2004-11&rft_id=info:hdl/10161/15063&rft_id=info:pmid/15518812&rft_id=info:doi/10.1016/j.virol.2004.08.017&rft.aulast=Dellis&rft.aufirst=S&rft.au=Strickland, KC&rft.au=McCrary, WJ&rft.au=Patel, A&rft.au=Stocum, E&rft.au=Wright, CF&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.77-83&rft.date=2005-01&rft_id=info:doi/10.1038/nature03207&rft_id=https://api.semanticscholar.org/CorpusID:4344740#id-name=S2CID&rft_id=info:pmid/15635413&rft_id=info:bibcode/2005Natur.433...77A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Lam, YW&rft.au=Leung, AK&rft.au=Ong, SE&rft.au=Lyon, CE&rft.au=Lamond, AI&rft.au=Mann, M&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.119-26&rft.date=2004-11&rft_id=https://api.semanticscholar.org/CorpusID:6654604#id-name=S2CID&rft_id=info:pmid/15782174&rft_id=info:doi/10.1038/nmeth715&rft.aulast=Ong&rft.aufirst=SE&rft.au=Mittler, G&rft.au=Mann, M&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
  • Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer". Journal of Cellular Biochemistry. 97 (6): 1275–82. doi:10.1002/jcb.20725. PMID 16552754. S2CID 9804734.1275-82&rft.date=2006-04&rft_id=https://api.semanticscholar.org/CorpusID:9804734#id-name=S2CID&rft_id=info:pmid/16552754&rft_id=info:doi/10.1002/jcb.20725&rft.aulast=Martínez-Arribas&rft.aufirst=F&rft.au=Agudo, D&rft.au=Pollán, M&rft.au=Gómez-Esquer, F&rft.au=Díaz-Gil, G&rft.au=Lucas, R&rft.au=Schneider, J&rfr_id=info:sid/en.wikipedia.org:RBM3" class="Z3988">
 

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