Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally.[3] 2 grams of propacetamol are equivalent to 1g of paracetamol.[4]
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | IV[1][2] |
| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | 2.4 hours [1] |
| Excretion | Renal |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.060.336 |
| Chemical and physical data | |
| Formula | C14H20N2O3 |
| Molar mass | 264.325 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
See also
editReferences
edit- ^ a b Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol". British Journal of Clinical Pharmacology. 34 (1): 79–81. doi:10.1111/j.1365-2125.1992.tb04112.x. PMC 1381380. PMID 1633071.79-81&rft.date=1992&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381380#id-name=PMC&rft_id=info:pmid/1633071&rft_id=info:doi/10.1111/j.1365-2125.1992.tb04112.x&rft.aulast=Bannwarth&rft.aufirst=B&rft.au=Netter, P&rft.au=Lapicque, F&rft.au=Gillet, P&rft.au=Péré, P&rft.au=Boccard, E&rft.au=Royer, RJ&rft.au=Gaucher, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381380&rfr_id=info:sid/en.wikipedia.org:Propacetamol" class="Z3988">
- ^ a b Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]". BMC Anesthesiology. 4 (1): 6. doi:10.1186/1471-2253-4-6. PMC 520811. PMID 15367329.
- ^ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery". British Journal of Anaesthesiology. 94 (5): 642–648. doi:10.1093/bja/aei109. PMID 15790675.642-648&rft.date=2005&rft_id=info:doi/10.1093/bja/aei109&rft_id=info:pmid/15790675&rft.aulast=Moller&rft.aufirst=PL&rft.au=Sindet-Pedersen, S&rft.au=Petersen, CT&rft.au=Juhl, GI&rft.au=Dillenschneider, A&rft.au=Skoglund, LA&rft_id=https://doi.org/10.1093%2Fbja%2Faei109&rfr_id=info:sid/en.wikipedia.org:Propacetamol" class="Z3988">
- ^ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". International Journal of Clinical Pharmacology and Therapeutics. 42 (1): 50–57. doi:10.5414/cpp42050. PMID 14756388.50-57&rft.date=2004&rft_id=info:doi/10.5414/cpp42050&rft_id=info:pmid/14756388&rft.aulast=Flouvat&rft.aufirst=B&rft.au=Leneveu, A&rft.au=Fitoussi, S&rft.au=Delhotal-Landes, B&rft.au=Gendron, A&rfr_id=info:sid/en.wikipedia.org:Propacetamol" class="Z3988">
 | This analgesic-related article is a stub. You can help Wikipedia by expanding it. |