Polyamine-modulated factor 1

PMF1
Identifiers
Aliases	PMF1, polyamine modulated factor 1
External IDs	OMIM: 609176; MGI: 1914287; HomoloGene: 5224; GeneCards: PMF1; OMA:PMF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,240,042 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,317,638 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; right auricle; ; ectocervix; ; skin of leg; ; left ventricle; ; granulocyte;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; tibiofemoral joint; ; blastocyst; ; internal carotid artery; ; lip; ; morula; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; leucine zipper domain binding; protein binding;
Cellular component	chromosome; cytosol; MIS12/MIND type complex; chromosome, centromeric region; nucleus; kinetochore; transcription regulator complex; nucleoplasm; Golgi apparatus; intracellular membrane-bounded organelle; nuclear MIS12/MIND complex;
Biological process	chromosome segregation; cell division; cell cycle; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11243
	67037
	ENSG00000160783
	ENSMUSG00000028066
	Q6P1K2
	Q9CPV5
	NM_007221; NM_001199653; NM_001199654
	NM_025928; NM_001310605
	NP_001186582; NP_001186583; NP_009152
	NP_001297534; NP_080204
	Wikidata
View/Edit Human	View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.^[5]^[6]

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.22095-101&rft.date=1999-07&rft_id=info:doi/10.1074/jbc.274.31.22095&rft_id=info:pmid/10419538&rft.aulast=Wang&rft.aufirst=Y&rft.au=Devereux, W&rft.au=Stewart, TM&rft.au=Casero, RA&rft_id=https://doi.org/10.1074%2Fjbc.274.31.22095&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
^ "Entrez Gene: PMF1 polyamine-modulated factor 1".
^ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.2255-68&rft.date=2004-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519#id-name=PMC&rft_id=info:pmid/15371340&rft_id=info:doi/10.1101/gad.1234104&rft.aulast=Cheeseman&rft.aufirst=IM&rft.au=Niessen, S&rft.au=Anderson, S&rft.au=Hyndman, F&rft.au=Yates, JR&rft.au=Oegema, K&rft.au=Desai, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
^ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.1135-41&rft.date=2004-11&rft_id=https://api.semanticscholar.org/CorpusID:39408000#id-name=S2CID&rft_id=info:pmid/15502821&rft_id=info:doi/10.1038/ncb1187&rft.aulast=Obuse&rft.aufirst=C&rft.au=Iwasaki, O&rft.au=Kiyomitsu, T&rft.au=Goshima, G&rft.au=Toyoda, Y&rft.au=Yanagida, M&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">

Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.45-9&rft.date=2001-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221710#id-name=PMC&rft_id=info:pmid/11256947&rft_id=info:doi/10.1042/0264-6021:3550045&rft.aulast=Wang&rft.aufirst=Y&rft.au=Devereux, W&rft.au=Stewart, TM&rft.au=Casero, RA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221710&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.79-86&rft.date=2002-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222765#id-name=PMC&rft_id=info:pmid/12020345&rft_id=info:doi/10.1042/BJ20020211&rft.aulast=Wang&rft.aufirst=Y&rft.au=Devereux, W&rft.au=Stewart, TM&rft.au=Casero, RA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222765&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.2255-68&rft.date=2004-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519#id-name=PMC&rft_id=info:pmid/15371340&rft_id=info:doi/10.1101/gad.1234104&rft.aulast=Cheeseman&rft.aufirst=IM&rft.au=Niessen, S&rft.au=Anderson, S&rft.au=Hyndman, F&rft.au=Yates, JR&rft.au=Oegema, K&rft.au=Desai, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.1135-41&rft.date=2004-11&rft_id=https://api.semanticscholar.org/CorpusID:39408000#id-name=S2CID&rft_id=info:pmid/15502821&rft_id=info:doi/10.1038/ncb1187&rft.aulast=Obuse&rft.aufirst=C&rft.au=Iwasaki, O&rft.au=Kiyomitsu, T&rft.au=Goshima, G&rft.au=Toyoda, Y&rft.au=Yanagida, M&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">
Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.9-17&rft.date=2006-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063780#id-name=PMC&rft_id=info:pmid/16585270&rft_id=info:doi/10.1083/jcb.200509158&rft.aulast=Kline&rft.aufirst=SL&rft.au=Cheeseman, IM&rft.au=Hori, T&rft.au=Fukagawa, T&rft.au=Desai, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063780&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419538-5] Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.22095-101&rft.date=1999-07&rft_id=info:doi/10.1074/jbc.274.31.22095&rft_id=info:pmid/10419538&rft.aulast=Wang&rft.aufirst=Y&rft.au=Devereux, W&rft.au=Stewart, TM&rft.au=Casero, RA&rft_id=https://doi.org/10.1074%2Fjbc.274.31.22095&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">

[entrez-6] "Entrez Gene: PMF1 polyamine-modulated factor 1".

[pmid15371340-7] Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.2255-68&rft.date=2004-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519#id-name=PMC&rft_id=info:pmid/15371340&rft_id=info:doi/10.1101/gad.1234104&rft.aulast=Cheeseman&rft.aufirst=IM&rft.au=Niessen, S&rft.au=Anderson, S&rft.au=Hyndman, F&rft.au=Yates, JR&rft.au=Oegema, K&rft.au=Desai, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517519&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">

[pmid15502821-8] Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.1135-41&rft.date=2004-11&rft_id=https://api.semanticscholar.org/CorpusID:39408000#id-name=S2CID&rft_id=info:pmid/15502821&rft_id=info:doi/10.1038/ncb1187&rft.aulast=Obuse&rft.aufirst=C&rft.au=Iwasaki, O&rft.au=Kiyomitsu, T&rft.au=Goshima, G&rft.au=Toyoda, Y&rft.au=Yanagida, M&rfr_id=info:sid/en.wikipedia.org:Polyamine-modulated factor 1" class="Z3988">

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]

Polyamine-modulated factor 1

Interactions

References

Further reading