Persistent aura without infarction (PAWOI) is a rare and seemingly benign[1] condition, first described in case reports in 1982 as "prolonged/persistent migraine aura status",[2] and in 2000 as "migraine aura status",[3][4] that is not yet fully understood. PAWOI is said to possibly be a factor involved in a variety of neurological symptoms, including visual snow, loss of vision, increased afterimages, tinnitus, and others. The pathogenesis of PAWOI is unknown. It is not clear which medical examinations are useful in diagnosing PAWOI. At present, PAWOI is usually diagnosed solely based on the patient's current and past symptoms. It is possible that an "overactive brain" or a chemical imbalance underlies the disorder. Various medications have been tried as treatment, notably acetazolamide,[3] valproate,[4] lamotrigine,[1] topiramate, and furosemide.[5]
| Persistent aura without infarction | |
|---|---|
| Specialty | Neurology, Neuro-ophthalmology |
| Symptoms | Prolonged aura in vision, Visual snow |
| Duration | Long-term |
| Causes | Unknown |
| Risk factors | Migraine sufferer |
| Differential diagnosis | Scintillating scotoma, Visual snow |
References
edit- ^ a b Chen, WT; Fuh, JL; Lu, SR; Wang, SJ (September 2001). "Persistent migrainous visual phenomena might be responsive to lamotrigine". Headache. 41 (8): 823–5. doi:10.1046/j.1526-4610.2001.01150.x. PMID 11576209. S2CID 20313330.
- ^ Haas, David C. (February 1982). "Prolonged migraine aura status". Annals of Neurology. 11 (2): 197–9. doi:10.1002/ana.410110217. PMID 7073253. S2CID 73205218.
- ^ a b Haan, J; Sluis, P; Sluis, LH; Ferrari, MD (28 November 2000). "Acetazolamide treatment for migraine aura status". Neurology. 55 (10): 1588–9. doi:10.1212/WNL.55.10.1588. PMID 11094126. S2CID 44314478.
- ^ a b Rothrock, JF (January 1997). "Successful treatment of persistent migraine aura with divalproex sodium". Neurology. 48 (1): 261–2. doi:10.1212/WNL.48.1.261. PMID 9008529. S2CID 44580050.
- ^ Rozen, Todd D. (12 September 2000). "Treatment of a prolonged migrainous aura with intravenous furosemide". Neurology. 55 (5): 732–3. doi:10.1212/WNL.55.5.732. PMID 10980751. S2CID 23474035.
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