Patchoulol synthase

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Patchoulol synthase
Patchoulol synthase
Identifiers
EC no.	4.2.3.70
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate H₂O

\rightleftharpoons

patchoulol diphosphate

References

^ Croteau R, Munck SL, Akoh CC, Fisk HJ, Satterwhite DM (July 1987). "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Archives of Biochemistry and Biophysics. 256 (1): 56–68. doi:10.1016/0003-9861(87)90425-5. PMID 3038029.56-68&rft.date=1987-07&rft_id=info:doi/10.1016/0003-9861(87)90425-5&rft_id=info:pmid/3038029&rft.aulast=Croteau&rft.aufirst=R&rft.au=Munck, SL&rft.au=Akoh, CC&rft.au=Fisk, HJ&rft.au=Satterwhite, DM&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">
^ Munck SL, Croteau R (October 1990). "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Archives of Biochemistry and Biophysics. 282 (1): 58–64. doi:10.1016/0003-9861(90)90086-e. PMID 2171435.58-64&rft.date=1990-10&rft_id=info:doi/10.1016/0003-9861(90)90086-e&rft_id=info:pmid/2171435&rft.aulast=Munck&rft.aufirst=SL&rft.au=Croteau, R&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">
^ Faraldos JA, Wu S, Chappell J, Coates RM (March 2010). "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-²H₁]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". Journal of the American Chemical Society. 132 (9): 2998–3008. doi:10.1021/ja909251r. PMID 20148554.2998-3008&rft.date=2010-03&rft_id=info:doi/10.1021/ja909251r&rft_id=info:pmid/20148554&rft.aulast=Faraldos&rft.aufirst=JA&rft.au=Wu, S&rft.au=Chappell, J&rft.au=Coates, RM&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">

External links

Patchoulol synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Croteau R, Munck SL, Akoh CC, Fisk HJ, Satterwhite DM (July 1987). "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Archives of Biochemistry and Biophysics. 256 (1): 56–68. doi:10.1016/0003-9861(87)90425-5. PMID 3038029.56-68&rft.date=1987-07&rft_id=info:doi/10.1016/0003-9861(87)90425-5&rft_id=info:pmid/3038029&rft.aulast=Croteau&rft.aufirst=R&rft.au=Munck, SL&rft.au=Akoh, CC&rft.au=Fisk, HJ&rft.au=Satterwhite, DM&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">

[2] Munck SL, Croteau R (October 1990). "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Archives of Biochemistry and Biophysics. 282 (1): 58–64. doi:10.1016/0003-9861(90)90086-e. PMID 2171435.58-64&rft.date=1990-10&rft_id=info:doi/10.1016/0003-9861(90)90086-e&rft_id=info:pmid/2171435&rft.aulast=Munck&rft.aufirst=SL&rft.au=Croteau, R&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">

[3] Faraldos JA, Wu S, Chappell J, Coates RM (March 2010). "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-²H₁]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". Journal of the American Chemical Society. 132 (9): 2998–3008. doi:10.1021/ja909251r. PMID 20148554.2998-3008&rft.date=2010-03&rft_id=info:doi/10.1021/ja909251r&rft_id=info:pmid/20148554&rft.aulast=Faraldos&rft.aufirst=JA&rft.au=Wu, S&rft.au=Chappell, J&rft.au=Coates, RM&rfr_id=info:sid/en.wikipedia.org:Patchoulol synthase" class="Z3988">

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