Pascolizumab is a humanized monoclonal antibody for the treatment of asthma.[1] A Phase II clinical trial in patients with symptomatic glucocorticoid naive asthma was conducted in 2001/2002.[2] Development was discontinued as it showed little benefit.[3]
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | IL-4 |
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References
edit- ^ Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM (October 2002). "Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma". Clinical and Experimental Immunology. 130 (1): 93–100. doi:10.1046/j.1365-2249.2002.01973.x. PMC 1906490. PMID 12296858.93-100&rft.date=2002-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906490#id-name=PMC&rft_id=info:pmid/12296858&rft_id=info:doi/10.1046/j.1365-2249.2002.01973.x&rft.aulast=Hart&rft.aufirst=TK&rft.au=Blackburn, MN&rft.au=Brigham-Burke, M&rft.au=Dede, K&rft.au=Al-Mahdi, N&rft.au=Zia-Amirhosseini, P&rft.au=Cook, RM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906490&rfr_id=info:sid/en.wikipedia.org:Pascolizumab" class="Z3988">
- ^ Clinical trial number NCT00024544 for "Pilot Study in Patients With Symptomatic Steroid-Naive Asthma" at ClinicalTrials.gov
- ^ Bice JB, Leechawengwongs E, Montanaro A (2014). "Biologic targeted therapy in allergic asthma". Annals of Allergy, Asthma & Immunology. 112 (2): 108 - 115. doi:10.1016/j.anai.2013.12.013.
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