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para-Bromoamphetamine (PBA), also known as 4-bromoamphetamine (4-BA), is an amphetamine derivative which acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA) and produces stimulant effects.
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| Formula | C9H12BrN |
| Molar mass | 214.106 g·mol−1 |
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Another related compound is para-bromomethamphetamine (PBMA) known by the codename V-111.[1]
Pharmacology
editPBA has been found to be a monoamine oxidase A (MAO-A) inhibitor, with an IC50 of 1,500 nM.[2]
Neurotoxicity
editLike most other para-substituted amphetamines, PBA can be neurotoxic and may deplete the brain of 5-hydroxyindoles for at least a week.[3]
See also
edit- Substituted amphetamines
- 4-Bromomethcathinone (4-BMC)
- 4-Fluoroamphetamine (4-FA)
- para-Chloroamphetamine (PCA)
- para-Iodoamphetamine (PIA)
References
edit- ^ Magyar K, Tekes K, Zólyomi G, Szüts T, Knoll J (1981). "The fate of p-bromo-methylamphetamine (V-111) in the body". Acta Physiologica Academiae Scientiarum Hungaricae. 57 (3): 285–307. PMID 7304194.
- ^ Reyes-Parada M, Iturriaga-Vasquez P, Cassels BK (2019). "Amphetamine Derivatives as Monoamine Oxidase Inhibitors". Front Pharmacol. 10: 1590. doi:10.3389/fphar.2019.01590. PMC 6989591. PMID 32038257.
- ^ Fuller RW, Baker JC, Perry KW, Molloy BB (October 1975). "Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: drug levels in brain and effects on brain serotonin metabolism". Neuropharmacology. 14 (10): 739–46. doi:10.1016/0028-3908(75)90099-4. PMID 1196472. S2CID 9620299.