PPP3R1

PPP3R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AUI, 1M63, 1MF8, 2P6B, 3LL8, 4F0Z, 4OR9, 4ORA, 4ORC, 4ORB
Identifiers
Aliases	PPP3R1, CALNB1, CNB, CNB1, protein phosphatase 3 regulatory subunit B, alpha
External IDs	OMIM: 601302; MGI: 107172; HomoloGene: 68099; GeneCards: PPP3R1; OMA:PPP3R1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	68,256,237 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	17,150,375 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; nucleus accumbens; ; Achilles tendon; ; right frontal lobe; ; monocyte; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; cerebellar hemisphere; ; Amygdala;
	Top expressed in
	CA3 field; ; perirhinal cortex; ; Region I of hippocampus proper; ; olfactory tubercle; ; entorhinal cortex; ; dentate gyrus; ; prefrontal cortex; ; primary motor cortex; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein domain specific binding; metal ion binding; calmodulin binding; protein binding; calcium-dependent protein serine/threonine phosphatase activity; cyclosporin A binding; phosphoprotein phosphatase activity; phosphatase binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; nucleoplasm; sarcolemma; calcineurin complex; mitochondrion;
Biological process	Fc-epsilon receptor signaling pathway; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; Wnt signaling pathway, calcium modulating pathway; branching involved in blood vessel morphogenesis; epithelial to mesenchymal transition; heart development; Schwann cell development; myelination in peripheral nervous system; calcineurin-NFAT signaling cascade; protein localization to nucleus; lung epithelial cell differentiation; protein import into nucleus; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5534
	19058
	ENSG00000221823
	ENSMUSG00000033953
	P63098
	Q63810
	NM_000945
	NM_024459
	NP_000936
	NP_077779
	Wikidata
View/Edit Human	View/Edit Mouse

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.^[5]^[6]^[7]

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221823 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033953 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.2–3&rft.pages=236-41&rft.date=1997-01&rft_id=info:doi/10.1159/000134198&rft_id=info:pmid/8978785&rft.aulast=Wang&rft.aufirst=MG&rft.au=Yi, H&rft.au=Guerini, D&rft.au=Klee, CB&rft.au=McBride, OW&rft_id=https://zenodo.org/record/1235418&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2 -binding subunit of the Ca2 /calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.675-82&rft.date=1990-03&rft_id=info:doi/10.1089/dna.1.1989.8.675&rft_id=info:pmid/2558868&rft.aulast=Guerini&rft.aufirst=D&rft.au=Krinks, MH&rft.au=Sikela, JM&rft.au=Hahn, WE&rft.au=Klee, CB&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".
^ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ (ed.). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLOS Genet. 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329.

Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain". J. Biol. Chem. 270 (26): 15463–6. doi:10.1074/jbc.270.26.15463. PMID 7541044.15463-6&rft.date=1995&rft_id=info:doi/10.1074/jbc.270.26.15463&rft_id=info:pmid/7541044&rft.aulast=Kawamura&rft.aufirst=A&rft.au=Su, MS&rft_id=https://doi.org/10.1074%2Fjbc.270.26.15463&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID 8524402. S2CID 4337105.641-4&rft.date=1996&rft_id=info:doi/10.1038/378641a0&rft_id=https://api.semanticscholar.org/CorpusID:4337105#id-name=S2CID&rft_id=info:pmid/8524402&rft_id=info:bibcode/1995Natur.378..641K&rft.aulast=Kissinger&rft.aufirst=CR&rft.au=Parge, HE&rft.au=Knighton, DR&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2 ". Biochemistry. 38 (38): 12481–9. doi:10.1021/bi990492w. PMID 10493818.12481-9&rft.date=1999&rft_id=info:doi/10.1021/bi990492w&rft_id=info:pmid/10493818&rft.aulast=Feng&rft.aufirst=B&rft.au=Stemmer, PM&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15)". DNA Seq. 9 (4): 227–30. doi:10.3109/10425179809105209. PMID 10520753.227-30&rft.date=1999&rft_id=info:doi/10.3109/10425179809105209&rft_id=info:pmid/10520753&rft.aulast=Stratakis&rft.aufirst=CA&rft.au=Taymans, SE&rft_id=https://zenodo.org/record/1235831&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Nishio H, Matsui K, Tsuji H, et al. (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis". Histochem. Cell Biol. 114 (1): 9–14. doi:10.1007/s004180000168. PMID 10959817. S2CID 21530150.9-14&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:21530150#id-name=S2CID&rft_id=info:pmid/10959817&rft_id=info:doi/10.1007/s004180000168&rft.aulast=Nishio&rft.aufirst=H&rft.au=Matsui, K&rft.au=Tsuji, H&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2 )-binding proteins in the retina: from discovery to etiology of human disease(1)". Biochim. Biophys. Acta. 1498 (2–3): 233–51. doi:10.1016/S0167-4889(00)00099-9. PMID 11108966.2–3&rft.pages=233-51&rft.date=2001&rft_id=info:doi/10.1016/S0167-4889(00)50099-9&rft_id=info:pmid/11108966&rft.aulast=Sokal&rft.aufirst=I&rft.au=Li, N&rft.au=Verlinde, CL&rft_id=https://doi.org/10.1016%2FS0167-4889%2800%2950099-9&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2 )/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. S2CID 5278706.863-75&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:5278706#id-name=S2CID&rft_id=info:pmid/11439183&rft_id=info:doi/10.1016/S0092-8674(01)00396-8&rft.aulast=Graef&rft.aufirst=IA&rft.au=Chen, F&rft.au=Chen, L&rft_id=https://doi.org/10.1016%2FS0092-8674%2801%2900396-8&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Al-Daraji WI, Grant KR, Ryan K, et al. (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A." J. Invest. Dermatol. 118 (5): 779–88. doi:10.1046/j.1523-1747.2002.01709.x. PMID 11982754.779-88&rft.date=2002&rft_id=info:doi/10.1046/j.1523-1747.2002.01709.x&rft_id=info:pmid/11982754&rft.aulast=Al-Daraji&rft.aufirst=WI&rft.au=Grant, KR&rft.au=Ryan, K&rft_id=https://doi.org/10.1046%2Fj.1523-1747.2002.01709.x&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12037–42. Bibcode:2002PNAS...9912037H. doi:10.1073/pnas.192206699. PMC 129394. PMID 12218175.12037-42&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129394#id-name=PMC&rft_id=info:pmid/12218175&rft_id=info:doi/10.1073/pnas.192206699&rft_id=info:bibcode/2002PNAS...9912037H&rft.aulast=Huai&rft.aufirst=Q&rft.au=Kim, HY&rft.au=Liu, Y&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129394&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13522–6. Bibcode:2002PNAS...9913522J. doi:10.1073/pnas.212504399. PMC 129706. PMID 12357034.13522-6&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129706#id-name=PMC&rft_id=info:pmid/12357034&rft_id=info:doi/10.1073/pnas.212504399&rft_id=info:bibcode/2002PNAS...9913522J&rft.aulast=Jin&rft.aufirst=L&rft.au=Harrison, SC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129706&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.174-80&rft.date=2003&rft_id=info:doi/10.1006/viro.2002.1676&rft_id=info:pmid/12482669&rft.aulast=Bennasser&rft.aufirst=Y&rft.au=Badou, A&rft.au=Tkaczuk, J&rft.au=Bahraoui, E&rft_id=https://doi.org/10.1006%2Fviro.2002.1676&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Curr. Biol. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160. S2CID 5934014.2156-61&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:5934014#id-name=S2CID&rft_id=info:pmid/15589160&rft_id=info:doi/10.1016/j.cub.2004.11.002&rft.aulast=Bittinger&rft.aufirst=MA&rft.au=McWhinnie, E&rft.au=Meltzer, J&rft_id=https://doi.org/10.1016%2Fj.cub.2004.11.002&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.724-31&rft.date=2005&rft_id=info:pmid/15815621&rft_id=info:doi/10.1038/nature03466&rft_id=info:bibcode/2005Natur.434..724H&rft.aulast=Hillier&rft.aufirst=LW&rft.au=Graves, TA&rft.au=Fulton, RS&rft_id=https://doi.org/10.1038%2Fnature03466&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses". Immunity. 24 (2): 141–52. doi:10.1016/j.immuni.2005.12.013. PMID 16473827.141-52&rft.date=2006&rft_id=info:doi/10.1016/j.immuni.2005.12.013&rft_id=info:pmid/16473827&rft.aulast=Winslow&rft.aufirst=MM&rft.au=Gallo, EM&rft.au=Neilson, JR&rft.au=Crabtree, GR&rft_id=https://doi.org/10.1016%2Fj.immuni.2005.12.013&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">
Liu Q, Wilkins BJ, Lee YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth". Mol. Cell. Biol. 26 (10): 3785–97. doi:10.1128/MCB.26.10.3785-3797.2006. PMC 1489013. PMID 16648474.3785-97&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489013#id-name=PMC&rft_id=info:pmid/16648474&rft_id=info:doi/10.1128/MCB.26.10.3785-3797.2006&rft.aulast=Liu&rft.aufirst=Q&rft.au=Wilkins, BJ&rft.au=Lee, YJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489013&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221823 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033953 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978785-5] Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.2–3&rft.pages=236-41&rft.date=1997-01&rft_id=info:doi/10.1159/000134198&rft_id=info:pmid/8978785&rft.aulast=Wang&rft.aufirst=MG&rft.au=Yi, H&rft.au=Guerini, D&rft.au=Klee, CB&rft.au=McBride, OW&rft_id=https://zenodo.org/record/1235418&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">

[pmid2558868-6] Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2 -binding subunit of the Ca2 /calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.675-82&rft.date=1990-03&rft_id=info:doi/10.1089/dna.1.1989.8.675&rft_id=info:pmid/2558868&rft.aulast=Guerini&rft.aufirst=D&rft.au=Krinks, MH&rft.au=Sikela, JM&rft.au=Hahn, WE&rft.au=Klee, CB&rfr_id=info:sid/en.wikipedia.org:PPP3R1" class="Z3988">

[entrez-7] "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".

[Cruchaga_2010-8] Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ (ed.). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLOS Genet. 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

PPP3R1

Clinical significance

References

Further reading