PPP1R9A

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.

PPP1R9A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WF8
Identifiers
Aliases	PPP1R9A, NRB1, NRBI, Neurabin-I, protein phosphatase 1 regulatory subunit 9A
External IDs	OMIM: 602468; MGI: 2442401; HomoloGene: 14247; GeneCards: PPP1R9A; OMA:PPP1R9A - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.3 Start 94,907,202 bp End 95,296,415 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 A1|6 1.86 cM Start 4,902,917 bp End 5,165,661 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell Parietal Lobe postcentral gyrus cerebellar vermis entorhinal cortex Pons external globus pallidus middle temporal gyrus optic nerve Top expressed in olfactory tubercle lateral septal nucleus nucleus accumbens ventromedial nucleus globus pallidus primary motor cortex arcuate nucleus cingulate gyrus anterior amygdaloid area subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein domain specific binding protein phosphatase 1 binding protein binding GTPase binding actin binding actin filament binding protein C-terminus binding protein kinase binding transmembrane transporter binding protein-containing complex binding Cellular component dendritic spine neck cytosol filopodium growth cone neuromuscular junction dendritic spine synapse growth cone lamellipodium cell junction soma cortical actin cytoskeleton neuron projection cytoskeleton lamellipodium cytoplasm postsynaptic density actin cytoskeleton dendrite postsynaptic actin cytoskeleton glutamatergic synapse Biological process regulation of filopodium assembly cell differentiation regulation of synapse structural plasticity regulation of synapse assembly ageing cellular response to toxic substance neuron development positive regulation of dendritic spine development nervous system development multicellular organism development regulation of actin filament polymerization excitatory postsynaptic potential negative regulation of long-term synaptic potentiation negative regulation of spontaneous neurotransmitter secretion positive regulation of long-term synaptic depression positive regulation of neuron projection development negative regulation of stress fiber assembly regulation of dendritic spine morphogenesis positive regulation of protein kinase activity actin filament organization calcium-mediated signaling neuron projection development modulation of chemical synaptic transmission postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55607 243725 Ensembl ENSG00000158528 ENSMUSG00000032827 UniProt Q9ULJ8 n/a RefSeq (mRNA) NM_001166160 NM_001166161 NM_001166162 NM_001166163 NM_017650 NM_181595 NM_001363809 RefSeq (protein) NP_001159632 NP_001159633 NP_001159634 NP_001159635 NP_060120 NP_001159635.1 n/a Location (UCSC) Chr 7: 94.91 – 95.3 Mb Chr 6: 4.9 – 5.17 Mb PubMed search
Wikidata
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Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nakanishi H, Obaishi H, Satoh A, et al. (1997). "Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation". J. Cell Biol. 139 (4): 951–61. doi:10.1083/jcb.139.4.951. PMC 2139968. PMID 9362513.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• McAvoy T, Allen PB, Obaishi H, et al. (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry. 38 (39): 12943–9. doi:10.1021/bi991227d. PMID 10504266.
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
• Oliver CJ, Terry-Lorenzo RT, Elliott E, et al. (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.