Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2gene.[5] It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.[6]
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.[7] Its structure is resolved via a mouse version in 2019, showing the predicted homotrimeric propeller.[8]
PIEZO2 is typically found in cell types that respond to physical touch, such as Merkel cells,[9] and is thought to regulate light touch response.[10]
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.[11]
Mice without PIEZO2 in their proprioceptive neurons show uncoordinated body movements, indicating that PIEZO2 plays a role in mammalian proprioception.[12]
^Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID31435011. S2CID201116189.225-229&rft.date=2019-09&rft_id=info:doi/10.1038/s41586-019-1505-8&rft_id=https://api.semanticscholar.org/CorpusID:201116189#id-name=S2CID&rft_id=info:pmid/31435011&rft_id=info:bibcode/2019Natur.573..225W&rft.aulast=Wang&rft.aufirst=L&rft.au=Zhou, H&rft.au=Zhang, M&rft.au=Liu, W&rft.au=Deng, T&rft.au=Zhao, Q&rft.au=Li, Y&rft.au=Lei, J&rft.au=Li, X&rft.au=Xiao, B&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". Science. 330 (6000): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. PMC3062430. PMID20813920.55-60&rft.date=2010-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062430#id-name=PMC&rft_id=info:pmid/20813920&rft_id=info:doi/10.1126/science.1193270&rft_id=info:bibcode/2010Sci...330...55C&rft.aulast=Coste&rft.aufirst=B&rft.au=Mathur, J&rft.au=Schmidt, M&rft.au=Earley, TJ&rft.au=Ranade, S&rft.au=Petrus, MJ&rft.au=Dubin, AE&rft.au=Patapoutian, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062430&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID31435011. S2CID201116189.225-229&rft.date=2019-09&rft_id=info:doi/10.1038/s41586-019-1505-8&rft_id=https://api.semanticscholar.org/CorpusID:201116189#id-name=S2CID&rft_id=info:pmid/31435011&rft_id=info:bibcode/2019Natur.573..225W&rft.aulast=Wang&rft.aufirst=L&rft.au=Zhou, H&rft.au=Zhang, M&rft.au=Liu, W&rft.au=Deng, T&rft.au=Zhao, Q&rft.au=Li, Y&rft.au=Lei, J&rft.au=Li, X&rft.au=Xiao, B&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Wu J, Lewis AH, Grandl J (January 2017). "Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels". Trends in Biochemical Sciences. 42 (1): 57–71. doi:10.1016/j.tibs.2016.09.004. PMC5407468. PMID27743844.57-71&rft.date=2017-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407468#id-name=PMC&rft_id=info:pmid/27743844&rft_id=info:doi/10.1016/j.tibs.2016.09.004&rft.aulast=Wu&rft.aufirst=J&rft.au=Lewis, AH&rft.au=Grandl, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407468&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Faucherre A, Nargeot J, Mangoni ME, Jopling C (October 2013). "piezo2b regulates vertebrate light touch response". The Journal of Neuroscience. 33 (43): 17089–94. doi:10.1523/jneurosci.0522-13.2013. PMC6618434. PMID24155313.17089-94&rft.date=2013-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618434#id-name=PMC&rft_id=info:pmid/24155313&rft_id=info:doi/10.1523/jneurosci.0522-13.2013&rft.aulast=Faucherre&rft.aufirst=A&rft.au=Nargeot, J&rft.au=Mangoni, ME&rft.au=Jopling, C&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618434&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, et al. (March 2013). "Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis". Proceedings of the National Academy of Sciences of the United States of America. 110 (12): 4667–72. Bibcode:2013PNAS..110.4667C. doi:10.1073/pnas.1221400110. PMC3607045. PMID23487782.4667-72&rft.date=2013-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607045#id-name=PMC&rft_id=info:pmid/23487782&rft_id=info:doi/10.1073/pnas.1221400110&rft_id=info:bibcode/2013PNAS..110.4667C&rft.aulast=Coste&rft.aufirst=B&rft.au=Houge, G&rft.au=Murray, MF&rft.au=Stitziel, N&rft.au=Bandell, M&rft.au=Giovanni, MA&rft.au=Philippakis, A&rft.au=Hoischen, A&rft.au=Riemer, G&rft.au=Steen, U&rft.au=Steen, VM&rft.au=Mathur, J&rft.au=Cox, J&rft.au=Lebo, M&rft.au=Rehm, H&rft.au=Weiss, ST&rft.au=Wood, JN&rft.au=Maas, RL&rft.au=Sunyaev, SR&rft.au=Patapoutian, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607045&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, et al. (December 2015). "Piezo2 is the principal mechanotransduction channel for proprioception". Nature Neuroscience. 18 (12): 1756–62. doi:10.1038/nn.4162. PMC4661126. PMID26551544.1756-62&rft.date=2015-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661126#id-name=PMC&rft_id=info:pmid/26551544&rft_id=info:doi/10.1038/nn.4162&rft.aulast=Woo&rft.aufirst=SH&rft.au=Lukacs, V&rft.au=de Nooij, JC&rft.au=Zaytseva, D&rft.au=Criddle, CR&rft.au=Francisco, A&rft.au=Jessell, TM&rft.au=Wilkinson, KA&rft.au=Patapoutian, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661126&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
^McMillin MJ, Beck AE, Chong JX, Shively KM, Buckingham KJ, Gildersleeve HI, et al. (May 2014). "Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5". American Journal of Human Genetics. 94 (5): 734–44. doi:10.1016/j.ajhg.2014.03.015. PMC4067551. PMID24726473.734-44&rft.date=2014-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067551#id-name=PMC&rft_id=info:pmid/24726473&rft_id=info:doi/10.1016/j.ajhg.2014.03.015&rft.aulast=McMillin&rft.aufirst=MJ&rft.au=Beck, AE&rft.au=Chong, JX&rft.au=Shively, KM&rft.au=Buckingham, KJ&rft.au=Gildersleeve, HI&rft.au=Aracena, MI&rft.au=Aylsworth, AS&rft.au=Bitoun, P&rft.au=Carey, JC&rft.au=Clericuzio, CL&rft.au=Crow, YJ&rft.au=Curry, CJ&rft.au=Devriendt, K&rft.au=Everman, DB&rft.au=Fryer, A&rft.au=Gibson, K&rft.au=Giovannucci Uzielli, ML&rft.au=Graham, JM&rft.au=Hall, JG&rft.au=Hecht, JT&rft.au=Heidenreich, RA&rft.au=Hurst, JA&rft.au=Irani, S&rft.au=Krapels, IP&rft.au=Leroy, JG&rft.au=Mowat, D&rft.au=Plant, GT&rft.au=Robertson, SP&rft.au=Schorry, EK&rft.au=Scott, RH&rft.au=Seaver, LH&rft.au=Sherr, E&rft.au=Splitt, M&rft.au=Stewart, H&rft.au=Stumpel, C&rft.au=Temel, SG&rft.au=Weaver, DD&rft.au=Whiteford, M&rft.au=Williams, MS&rft.au=Tabor, HK&rft.au=Smith, JD&rft.au=Shendure, J&rft.au=Nickerson, DA&rft.au=Bamshad, MJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067551&rfr_id=info:sid/en.wikipedia.org:PIEZO2" class="Z3988">
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