PDGFD

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.

PDGFD
Identifiers
Aliases	PDGFD, IEGF, SCDGF-B, SCDGFB, MSTP036, platelet derived growth factor D
External IDs	OMIM: 609673; MGI: 1919035; HomoloGene: 11875; GeneCards: PDGFD; OMA:PDGFD - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q22.3 Start 103,907,189 bp End 104,164,379 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A1 Start 6,168,584 bp End 6,378,850 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber germinal epithelium seminal vesicula adrenal cortex ventricular zone left adrenal cortex synovial joint right adrenal cortex Descending thoracic aorta ascending aorta Top expressed in interventricular septum ascending aorta facial motor nucleus Epithelium of choroid plexus aortic valve body of femur calvaria iris vestibular sensory epithelium anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function platelet-derived growth factor receptor binding growth factor activity Cellular component endoplasmic reticulum lumen membrane Golgi membrane extracellular region extracellular space Biological process cellular response to transforming growth factor beta stimulus positive regulation of smooth muscle cell chemotaxis positive regulation of MAP kinase activity positive regulation of fibroblast proliferation positive regulation of cell migration cellular response to platelet-derived growth factor stimulus multicellular organism development positive regulation of monocyte extravasation positive regulation of protein autophosphorylation positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus positive regulation of phosphatidylinositol 3-kinase signaling platelet-derived growth factor receptor signaling pathway positive regulation of glomerular mesangial cell proliferation positive regulation of cell division positive regulation of smooth muscle cell proliferation cellular response to hydrogen peroxide regulation of peptidyl-tyrosine phosphorylation blood coagulation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80310 71785 Ensembl ENSG00000170962 ENSMUSG00000032006 UniProt Q9GZP0 Q925I7 RefSeq (mRNA) NM_033135 NM_025208 NM_027924 NM_001357397 NM_001357398 RefSeq (protein) NP_079484 NP_149126 NP_082200 NP_001344326 NP_001344327 Location (UCSC) Chr 11: 103.91 – 104.16 Mb Chr 9: 6.17 – 6.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

Further reading

• Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol. 3 (5): 512–6. doi:10.1038/35074588. PMID 11331881. S2CID 25074372.
• LaRochelle WJ, Jeffers M, McDonald WF, et al. (2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol. 3 (5): 517–21. doi:10.1038/35074593. PMID 11331882. S2CID 19633551.
• Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes". Circulation. 103 (18): 2242–7. doi:10.1161/01.cir.103.18.2242. PMID 11342471.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
• Changsirikulchai S, Hudkins KL, Goodpaster TA, et al. (2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys". Kidney Int. 62 (6): 2043–54. doi:10.1046/j.1523-1755.2002.00662.x. PMID 12427128.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Taneda S, Hudkins KL, Topouzis S, et al. (2004). "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury". J. Am. Soc. Nephrol. 14 (10): 2544–55. doi:10.1097/01.ASN.0000089828.73014.C8. PMID 14514732.
• Uutela M, Wirzenius M, Paavonen K, et al. (2004). "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis". Blood. 104 (10): 3198–204. doi:10.1182/blood-2004-04-1485. PMID 15271796.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ray S, Gao C, Wyatt K, et al. (2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation". J. Biol. Chem. 280 (9): 8494–502. doi:10.1074/jbc.M413570200. PMID 15611105.
• Ustach CV, Kim HR (2005). "Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells". Mol. Cell. Biol. 25 (14): 6279–88. doi:10.1128/MCB.25.14.6279-6288.2005. PMC 1168822. PMID 15988036.
• Liu MY, Eyries M, Zhang C, et al. (2006). "Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1". Blood. 107 (6): 2322–9. doi:10.1182/blood-2005-06-2377. PMID 16189269.