Orotate reductase (NADPH)

In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction

orotate reductase (NADPH)
Identifiers
EC no.	1.3.1.15
CAS no.	37255-27-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

(S)-dihydroorotate NADP $\rightleftharpoons$ orotate NADPH H

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP , whereas its 3 products are orotate, NADPH, and H .

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.

References

• Taylor WH, Taylor ML, Eames DF (1966). "Two functionally different dihydroorotic dehydrogenases in bacteria". J. Bacteriol. 91 (6): 2251–6. PMC 316202. PMID 4380263.2251-6&rft.date=1966&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316202#id-name=PMC&rft_id=info:pmid/4380263&rft.aulast=Taylor&rft.aufirst=WH&rft.au=Taylor, ML&rft.au=Eames, DF&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316202&rfr_id=info:sid/en.wikipedia.org:Orotate reductase (NADPH)" class="Z3988">
• Ukada S, Vennesland B (1962). "Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase". J. Biol. Chem. 237: 2018–2024. PMID 13923427.2018-2024&rft.date=1962&rft_id=info:pmid/13923427&rft.aulast=Ukada&rft.aufirst=S&rft.au=Vennesland, B&rfr_id=info:sid/en.wikipedia.org:Orotate reductase (NADPH)" class="Z3988">