In enzymology, an orotate reductase (NADH) (EC 1.3.1.14) is an enzyme that catalyzes the chemical reaction
| orotate reductase (NADH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.14 | ||||||||
| CAS no. | 37255-26-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- (S)-dihydroorotate NAD orotate NADH H
Thus, the two substrates of this enzyme are (S)-dihydroorotate and NAD , whereas its 3 products are orotate, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NAD oxidoreductase. This enzyme is also called orotate reductase (NADH). This enzyme participates in pyrimidine metabolism. It has 2 cofactors: FAD, and FMN.
References
edit- FRIEDMANN HC, VENNESLAND B (1958). "Purification and properties of dihydro-orotic dehydrogenase". J. Biol. Chem. 233 (6): 1398–406. PMID 13610849.1398-406&rft.date=1958&rft_id=info:pmid/13610849&rft.aulast=FRIEDMANN&rft.aufirst=HC&rft.au=VENNESLAND, B&rfr_id=info:sid/en.wikipedia.org:Orotate reductase (NADH)" class="Z3988">
- FRIEDMANN HC, VENNESLAND B (1960). "Crystalline dihydroorotic dehydrogenase". J. Biol. Chem. 235: 1526–32. PMID 13825167.1526-32&rft.date=1960&rft_id=info:pmid/13825167&rft.aulast=FRIEDMANN&rft.aufirst=HC&rft.au=VENNESLAND, B&rfr_id=info:sid/en.wikipedia.org:Orotate reductase (NADH)" class="Z3988">
- LIEBERMAN I, KORNBERG A (1953). "Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I Dihydro-orotic dehydrogenase". Biochim. Biophys. Acta. 12 (1–2): 223–34. doi:10.1016/0006-3002(53)90141-3. PMID 13115431.1–2&rft.pages=223-34&rft.date=1953&rft_id=info:doi/10.1016/0006-3002(53)90141-3&rft_id=info:pmid/13115431&rft.aulast=LIEBERMAN&rft.aufirst=I&rft.au=KORNBERG, A&rfr_id=info:sid/en.wikipedia.org:Orotate reductase (NADH)" class="Z3988">
