In enzymology, a nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19) is an enzyme that catalyzes the chemical reaction
| nicotinate-nucleotide diphosphorylase (carboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Nicotinate-nucleotide pyrophosphorylase (carboxylating) hexamer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.4.2.19 | ||||||||
| CAS no. | 37277-74-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- nicotinate D-ribonucleotide diphosphate CO2 pyridine-2,3-dicarboxylate 5-phospho-alpha-D-ribose 1-diphosphate
The 3 substrates of this enzyme are nicotinate D-ribonucleotide, diphosphate, and CO2, whereas its two products are pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating). Other names in common use include quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), and quinolinic phosphoribosyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
editAs of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1QAP, 1QPN, 1QPO, 1QPQ, 1QPR, 1X1O, 2B7N, 2B7P, and 2B7Q.
References
edit- GHOLSON RK, UEDA I, OGASAWARA N, HENDERSON LM (1964). "The Enzymatic Conversion of Quinolinate to Nicotinic Acid Mononucleotide in Mammalian Liver". J. Biol. Chem. 239 (4): 1208–14. doi:10.1016/S0021-9258(18)91413-4. PMID 14165928.1208-14&rft.date=1964&rft_id=info:doi/10.1016/S0021-9258(18)91413-4&rft_id=info:pmid/14165928&rft.aulast=GHOLSON&rft.aufirst=RK&rft.au=UEDA, I&rft.au=OGASAWARA, N&rft.au=HENDERSON, LM&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2991413-4&rfr_id=info:sid/en.wikipedia.org:Nicotinate-nucleotide diphosphorylase (carboxylating)" class="Z3988">
- Packman PM, Jakoby WB (1965). "Crystalline quinolinate phosphoribosyltransferase". J. Biol. Chem. 240 (10): 4107–8. doi:10.1016/S0021-9258(18)97157-7. PMID 5320648.4107-8&rft.date=1965&rft_id=info:doi/10.1016/S0021-9258(18)97157-7&rft_id=info:pmid/5320648&rft.aulast=Packman&rft.aufirst=PM&rft.au=Jakoby, WB&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2997157-7&rfr_id=info:sid/en.wikipedia.org:Nicotinate-nucleotide diphosphorylase (carboxylating)" class="Z3988">
