Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA), an ω-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative stress, containing a substituted tetrahydrofuran ring. Measurement of the neurofurans may ultimately prove useful in diagnosis, timing, and selection of dosages in the treatment and chemoprevention of neurodegenerative disease.[1]
References
edit- ^ Song WL; Lawson JA; Reilly D; Rokach J; Chang CT; Giasson B & FitzGerald GA. (2007). "Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid". J Biol Chem. 283 (1): 6–16. doi:10.1074/jbc.M706124200. PMID 17921521.6-16&rft.date=2007&rft_id=info:doi/10.1074/jbc.M706124200&rft_id=info:pmid/17921521&rft.au=Song WL&rft.au=Lawson JA&rft.au=Reilly D&rft.au=Rokach J&rft.au=Chang CT&rft.au=Giasson B&rft.au=FitzGerald GA.&rft_id=https://doi.org/10.1074%2Fjbc.M706124200&rfr_id=info:sid/en.wikipedia.org:Neurofuran" class="Z3988">
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