Neuromedin B receptor

The neuromedin B receptor (NMBR), now known as BB₁ is a G protein-coupled receptor whose endogenous ligand is neuromedin B. In humans, this protein is encoded by the NMBR gene.

NMBR
Identifiers
Aliases	NMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDs	OMIM: 162341; MGI: 1100525; HomoloGene: 20560; GeneCards: NMBR; OMA:NMBR - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q24.1 Start 142,058,330 bp End 142,147,122 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis prefrontal cortex olfactory zone of nasal mucosa ganglionic eminence right uterine tube caudate nucleus gonad putamen nucleus accumbens n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled peptide receptor activity signal transducer activity G protein-coupled receptor activity bombesin receptor activity Cellular component integral component of plasma membrane membrane integral component of membrane plasma membrane cytosol Biological process phospholipase C-activating G protein-coupled receptor signaling pathway bombesin receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4829 18101 Ensembl ENSG00000135577 ENSMUSG00000019865 UniProt P28336 O54799 RefSeq (mRNA) NM_002511 NM_001324307 NM_001324308 NM_008703 RefSeq (protein) NP_001311236 NP_001311237 NP_002502 NP_032729 Location (UCSC) Chr 6: 142.06 – 142.15 Mb n/a PubMed search
Wikidata
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Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.

Further reading

• Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells". J. Biol. Chem. 266 (28): 18771–9. doi:10.1016/S0021-9258(18)55129-2. PMID 1655761.18771-9&rft.date=1991&rft_id=info:doi/10.1016/S0021-9258(18)55129-2&rft_id=info:pmid/1655761&rft.aulast=Corjay&rft.aufirst=MH&rft.au=Dobrzanski, DJ&rft.au=Way, JM&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2955129-2&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750.871-81&rft.date=1995&rft_id=info:pmid/7723750&rft.aulast=Wu&rft.aufirst=JM&rft.au=Hoang, DO&rft.au=Feldman, RI&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Benya RV, Kusui T, Pradhan TK, et al. (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.10-20&rft.date=1995&rft_id=info:pmid/7838118&rft.aulast=Benya&rft.aufirst=RV&rft.au=Kusui, T&rft.au=Pradhan, TK&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction". Gastroenterology. 105 (6): 1672–80. doi:10.1016/0016-5085(93)91062-m. PMID 8253343.1672-80&rft.date=1994&rft_id=info:doi/10.1016/0016-5085(93)91062-m&rft_id=info:pmid/8253343&rft.aulast=Bitar&rft.aufirst=KN&rft.au=Zhu, XX&rft_id=https://doi.org/10.1016%2F0016-5085%2893%2991062-m&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. S2CID 20854144.41-54&rft.date=1993&rft_id=https://api.semanticscholar.org/CorpusID:20854144#id-name=S2CID&rft_id=info:pmid/8391296&rft_id=info:doi/10.1007/BF02736689&rft.aulast=Giladi&rft.aufirst=E&rft.au=Nagalla, SR&rft.au=Spindel, ER&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Fathi Z, Benya RV, Shapira H, et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding". J. Biol. Chem. 268 (20): 14622–6. doi:10.1016/S0021-9258(18)82378-X. PMID 8392057.14622-6&rft.date=1993&rft_id=info:doi/10.1016/S0021-9258(18)82378-X&rft_id=info:pmid/8392057&rft.aulast=Fathi&rft.aufirst=Z&rft.au=Benya, RV&rft.au=Shapira, H&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2982378-X&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. S2CID 30893871.111-8&rft.date=1996&rft_id=https://api.semanticscholar.org/CorpusID:30893871#id-name=S2CID&rft_id=info:pmid/8822519&rft_id=info:doi/10.1016/0196-9781(95)02088-8&rft.aulast=Kane&rft.aufirst=MA&rft.au=Toi-Scott, M&rft.au=Johnson, GL&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Sainz E, Akeson M, Mantey SA, et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639.15927-32&rft.date=1998&rft_id=info:doi/10.1074/jbc.273.26.15927&rft_id=info:pmid/9632639&rft.aulast=Sainz&rft.aufirst=E&rft.au=Akeson, M&rft.au=Mantey, SA&rft_id=https://doi.org/10.1074%2Fjbc.273.26.15927&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. S2CID 46035151.263-9&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:46035151#id-name=S2CID&rft_id=info:pmid/10544247&rft_id=info:doi/10.1016/S0014-5793(99)01346-0&rft.aulast=Lee&rft.aufirst=S&rft.au=Kim, Y&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Neuromedin B receptor" class="Z3988">
• Matusiak D, Glover S, Nathaniel R, et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253.

External links

• "Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-10-04. Retrieved 2007-10-25.
• Receptors, Bombesin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.