Methylenetetrahydrofolate—tRNA-(uracil-5-)-methyltransferase
In enzymology, a methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (EC 2.1.1.74) is an enzyme that catalyzes the chemical reaction
| methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.74 | ||||||||
| CAS no. | 74665-78-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- 5,10-methylenetetrahydrofolate tRNA containing uridine at position 54 FADH2 tetrahydrofolate tRNA containing ribothymidine at position 54 FAD
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, tRNA containing uridine at position 54, and FADH2, whereas its 3 products are tetrahydrofolate, tRNA containing ribothymidine at position 54, and FAD.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyl-transferase. Other names in common use include (FADH2-oxidizing), folate-dependent ribothymidyl synthase, methylenetetrahydrofolate-transfer ribonucleate uracil, 5-methyltransferase, 5,10-methylenetetrahydrofolate:tRNA-UPsiC, and (uracil-5-)-methyl-transferase.
References
edit- Delk AS, Nagle DP, Rabinowitz JC (1980). "Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of Streptococcus faecalis. Evidence for reduction of the 1-carbon unit by FADH2". J. Biol. Chem. 255 (10): 4387–90. PMID 6768721.4387-90&rft.date=1980&rft_id=info:pmid/6768721&rft.aulast=Delk&rft.aufirst=AS&rft.au=Nagle, DP&rft.au=Rabinowitz, JC&rfr_id=info:sid/en.wikipedia.org:Methylenetetrahydrofolate—tRNA-(uracil-5-)-methyltransferase" class="Z3988">
- Becker HF, Motorin Y, Sissler M, Florentz C, Grosjean H (1997). "Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs". J. Mol. Biol. 274 (4): 505–18. doi:10.1006/jmbi.1997.1417. PMID 9417931.505-18&rft.date=1997&rft_id=info:doi/10.1006/jmbi.1997.1417&rft_id=info:pmid/9417931&rft.aulast=Becker&rft.aufirst=HF&rft.au=Motorin, Y&rft.au=Sissler, M&rft.au=Florentz, C&rft.au=Grosjean, H&rft_id=https://univoak.eu/islandora/object/islandora%3A69893&rfr_id=info:sid/en.wikipedia.org:Methylenetetrahydrofolate—tRNA-(uracil-5-)-methyltransferase" class="Z3988">
