Mannosylglycerate synthase (EC 2.4.1.269) is an enzyme with systematic name GDP-mannose:D-glycerate 2-alpha-D-mannosyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| Mannosylglycerate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.269 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- GDP-mannose D-glycerate GDP 2-O-(alpha-D-mannopyranosyl)-D-glycerate
Depending on conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate.
See also
edit- EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase)
- EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase)
References
edit- ^ Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H (December 1999). "Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase". The Journal of Biological Chemistry. 274 (50): 35407–14. doi:10.1074/jbc.274.50.35407. PMID 10585410.35407-14&rft.date=1999-12&rft_id=info:doi/10.1074/jbc.274.50.35407&rft_id=info:pmid/10585410&rft.aulast=Martins&rft.aufirst=LO&rft.au=Empadinhas, N&rft.au=Marugg, JD&rft.au=Miguel, C&rft.au=Ferreira, C&rft.au=da Costa, MS&rft.au=Santos, H&rft_id=https://doi.org/10.1074%2Fjbc.274.50.35407&rfr_id=info:sid/en.wikipedia.org:Mannosylglycerate synthase" class="Z3988">
- ^ Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ (July 2005). "Structural dissection and high-throughput screening of mannosylglycerate synthase". Nature Structural & Molecular Biology. 12 (7): 608–14. doi:10.1038/nsmb950. PMID 15951819.608-14&rft.date=2005-07&rft_id=info:doi/10.1038/nsmb950&rft_id=info:pmid/15951819&rft.aulast=Flint&rft.aufirst=J&rft.au=Taylor, E&rft.au=Yang, M&rft.au=Bolam, DN&rft.au=Tailford, LE&rft.au=Martinez-Fleites, C&rft.au=Dodson, EJ&rft.au=Davis, BG&rft.au=Gilbert, HJ&rft.au=Davies, GJ&rfr_id=info:sid/en.wikipedia.org:Mannosylglycerate synthase" class="Z3988">
External links
edit- Mannosylglycerate synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
