MPHS may refer to:
- Miller Place High School, Miller Place, New York
- Manlius Pebble Hill School, DeWitt, New York
- Marysville Pilchuck High School, Marysville, Washington, United States
- May Pen High School, Clarendon, Jamaica
- Memorial Private High School, Houston, Texas
- Mount Pleasant High School (disambiguation)
- Mountain Pointe High School, Phoenix, Arizona, United States
- Myers Park High School, Charlotte, North Carolina, United States
- Myrtle Point High School, Myrtle Point, Oregon, United States
- Hulu Selangor Municipal Council (MPHS)