MAN1A1

MAN1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NXC
Identifiers
Aliases	MAN1A1, HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
External IDs	OMIM: 604344; MGI: 104677; HomoloGene: 4316; GeneCards: MAN1A1; OMA:MAN1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	119,349,761 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	53,952,705 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; renal medulla; ; pericardium; ; jejunal mucosa; ; lower lobe of lung; ; urethra; ; parotid gland; ; palpebral conjunctiva; ; Achilles tendon; ; skin of hip;
	Top expressed in
	parotid gland; ; mesenteric lymph nodes; ; lateral septal nucleus; ; vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; lacrimal gland; ; epithelium of stomach; ; otic placode; ; submandibular gland; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; hydrolase activity; mannosidase activity; hydrolase activity, acting on glycosyl bonds; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; extracellular exosome; endoplasmic reticulum; membrane; endoplasmic reticulum-Golgi intermediate compartment; cytosol;
Biological process	protein glycosylation; N-glycan processing; metabolism; Golgi apparatus mannose trimming;
	Sources:Amigo / QuickGO
Orthologs
	4121
	17155
	ENSG00000111885
	ENSMUSG00000003746
	P33908
	P45700
	NM_005907
	NM_008548
	NP_005898
	NP_032574
	Wikidata
View/Edit Human	View/Edit Mouse

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.^[5]^[6]

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111885 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003746 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B (Dec 1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney". Eur J Biochem. 217 (2): 535–40. doi:10.1111/j.1432-1033.1993.tb18274.x. PMID 8223597.535-40&rft.date=1993-12&rft_id=info:doi/10.1111/j.1432-1033.1993.tb18274.x&rft_id=info:pmid/8223597&rft.aulast=Bause&rft.aufirst=E&rft.au=Bieberich, E&rft.au=Rolfs, A&rft.au=Volker, C&rft.au=Schmidt, B&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1993.tb18274.x&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
^ ^a ^b "Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1".

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211. S2CID 13576808.783-90&rft.date=2001&rft_id=info:hdl/1874/5091&rft_id=https://api.semanticscholar.org/CorpusID:13576808#id-name=S2CID&rft_id=info:pmid/11530211&rft_id=info:doi/10.1016/S0300-9084(01)01314-1&rft.aulast=Land&rft.aufirst=A&rft.au=Braakman, I&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.377-82&rft.date=1992&rft_id=info:doi/10.1016/0042-6822(92)90331-I&rft_id=info:pmid/1736542&rft.aulast=Dedera&rft.aufirst=DA&rft.au=Gu, RL&rft.au=Ratner, L&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.371-80&rft.date=1990&rft_id=info:doi/10.1089/aid.1990.6.371&rft_id=info:pmid/2187500&rft.au=Kalyanaraman VS&rft.au=Rodriguez V&rft.au=Veronese F&rft.au=Rahman, R.&rft.au=Lusso, P.&rft.au=Devico, A.L.&rft.au=Copeland, T.&rft.au=Oroszlan, S.&rft.au=Gallo, R.C.&rft_id=https://zenodo.org/record/1235229&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.75-87&rft.date=1991&rft_id=info:doi/10.7883/yoken1952.43.75&rft_id=info:pmid/2283726&rft.au=Shimizu H&rft.au=Tsuchie H&rft.au=Honma H&rft.au=Yoshida, K&rft.au=Tsuruoka, T&rft.au=Ushijima, H&rft.au=Kitamura, T&rft_id=https://doi.org/10.7883%2Fyoken1952.43.75&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.10373-82&rft.date=1990&rft_id=info:doi/10.1016/S0021-9258(18)86956-3&rft_id=info:pmid/2355006&rft.au=Leonard CK&rft.au=Spellman MW&rft.au=Riddle L&rft.au=Harris, RJ&rft.au=Thomas, JN&rft.au=Gregory, TJ&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2986956-3&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex". J. Biol. Chem. 265 (5): 2640–9. doi:10.1016/S0021-9258(19)39849-7. PMID 2406237.2640-9&rft.date=1990&rft_id=info:doi/10.1016/S0021-9258(19)39849-7&rft_id=info:pmid/2406237&rft.aulast=Stein&rft.aufirst=BS&rft.au=Engleman, EG&rft_id=https://doi.org/10.1016%2FS0021-9258%2819%2939849-7&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.3384-8&rft.date=1989&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287137#id-name=PMC&rft_id=info:pmid/2541446&rft_id=info:doi/10.1073/pnas.86.9.3384&rft_id=info:bibcode/1989PNAS...86.3384P&rft.aulast=Pal&rft.aufirst=R&rft.au=Hoke, GM&rft.au=Sarngadharan, MG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287137&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/JVI.63.6.2452-2456.1989. PMC 250699. PMID 2542563.2452-6&rft.date=1989&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC250699#id-name=PMC&rft_id=info:pmid/2542563&rft_id=info:doi/10.1128/JVI.63.6.2452-2456.1989&rft.aulast=Dewar&rft.aufirst=RL&rft.au=Vasudevachari, MB&rft.au=Natarajan, V&rft.au=Salzman, NP&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC250699&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.163-9&rft.date=1989&rft_id=info:pmid/2649653&rft.au=Kozarsky K&rft.au=Penman M&rft.au=Basiripour L&rft.au=Haseltine, W&rft.au=Sodroski, J&rft.au=Krieger, M&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.265-82&rft.date=1988&rft_id=info:doi/10.1089/aid.1987.3.265&rft_id=info:pmid/2829950&rft.aulast=Robinson&rft.aufirst=WE&rft.au=Montefiori, DC&rft.au=Mitchell, WM&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.33-8&rft.date=1987&rft_id=info:doi/10.1016/S0006-291X(86)80330-8&rft_id=info:pmid/3099781&rft.au=Blough HA&rft.au=Pauwels R&rft.au=De Clercq E&rft.au=Cogniaux, J.&rft.au=Sprecher-Goldberger, S.&rft.au=Thiry, L.&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.9248-52&rft.date=1988&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC282716#id-name=PMC&rft_id=info:pmid/3264072&rft_id=info:doi/10.1073/pnas.85.23.9248&rft_id=info:bibcode/1988PNAS...85.9248M&rft.aulast=Montefiori&rft.aufirst=DC&rft.au=Robinson, WE&rft.au=Mitchell, WM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC282716&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein". Eur. J. Biochem. 233 (2): 644–9. doi:10.1111/j.1432-1033.1995.644_2.x. PMID 7588811.644-9&rft.date=1995&rft_id=info:doi/10.1111/j.1432-1033.1995.644_2.x&rft_id=info:pmid/7588811&rft.aulast=Bieberich&rft.aufirst=E&rft.au=Bause, E&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1995.644_2.x&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347. PMID 8093218.150-60&rft.date=1993&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237347#id-name=PMC&rft_id=info:pmid/8093218&rft_id=info:doi/10.1128/JVI.67.1.150-160.1993&rft.au=Fenouillet E&rft.au=Jones I&rft.au=Powell B&rft.au=Schmitt, D&rft.au=Kieny, MP&rft.au=Gluckman, JC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237347&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.11087-99&rft.date=1993&rft_id=info:doi/10.1021/bi00092a019&rft_id=info:pmid/8218172&rft.au=Yeh JC&rft.au=Seals JR&rft.au=Murphy CI&rft.au=Van Halbeek, Herman&rft.au=Cummings, Richard D.&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.213-20&rft.date=1996&rft_id=info:doi/10.1097/00042560-199607000-00001&rft_id=info:pmid/8673525&rft.au=Bolmstedt A&rft.au=Sjölander S&rft.au=Hansen JE&rft.au=Åkerblom, Lennart&rft.au=Hemming, Anna&rft.au=Hu, Shiu-Lok&rft.au=Morein, Bror&rft.au=Olofsson, Sigvard&rft_id=https://doi.org/10.1097%2F00042560-199607000-00001&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC 190813. PMID 8892864.7462-70&rft.date=1996&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190813#id-name=PMC&rft_id=info:pmid/8892864&rft_id=info:doi/10.1128/JVI.70.11.7462-7470.1996&rft.au=Hu H&rft.au=Shioda T&rft.au=Moriya C&rft.au=Xin, X&rft.au=Hasan, MK&rft.au=Miyake, K&rft.au=Shimada, T&rft.au=Nagai, Y&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190813&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.1–2&rft.pages=191-5&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:17660#id-name=S2CID&rft_id=info:pmid/9109416&rft_id=info:doi/10.1016/S0014-5793(97)00273-1&rft.aulast=Papandreou&rft.aufirst=MJ&rft.au=Fenouillet, E&rft_id=https://doi.org/10.1016%2FS0014-5793%2897%2900273-1&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">
Bieberich E, Treml K, Völker C, et al. (1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells". Eur. J. Biochem. 246 (3): 681–9. doi:10.1111/j.1432-1033.1997.t01-1-00681.x. PMID 9219526.681-9&rft.date=1997&rft_id=info:doi/10.1111/j.1432-1033.1997.t01-1-00681.x&rft_id=info:pmid/9219526&rft.au=Bieberich E&rft.au=Treml K&rft.au=Völker C&rft.au=Rolfs, Andreas&rft.au=Kalz-Fuller, Burga&rft.au=Bause, Ernst&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1997.t01-1-00681.x&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111885 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003746 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8223597-5] Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B (Dec 1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney". Eur J Biochem. 217 (2): 535–40. doi:10.1111/j.1432-1033.1993.tb18274.x. PMID 8223597.535-40&rft.date=1993-12&rft_id=info:doi/10.1111/j.1432-1033.1993.tb18274.x&rft_id=info:pmid/8223597&rft.aulast=Bause&rft.aufirst=E&rft.au=Bieberich, E&rft.au=Rolfs, A&rft.au=Volker, C&rft.au=Schmidt, B&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1993.tb18274.x&rfr_id=info:sid/en.wikipedia.org:MAN1A1" class="Z3988">

[entrez-6] "Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1".

[5]

[6]

[1]

[2]

[3]

[4]

MAN1A1

References

Further reading