Lelis syndrome

Lelis syndrome
Lelis syndrome
Other names	Ectodermal dysplasia-acanthosis nigricans syndrome
	This condition is inherited in an autosomal recessive manner.
Specialty	Medical genetics

Lelis syndrome is a genetic disorder, a rare condition with dermatological and dental findings^[1] characterized by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit,^[2] disturbances of skin pigmentation (perioral and periorbital hyperpigmentation, vitiligo, and perinevic leukoderma)^[2] and hypodontia. Transmission is autosomal recessive.^[1]^[3]

References

^ ^a ^b Samdani AJ (October 2004). "Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome)". J Coll Physicians Surg Pak. 14 (10): 626–7. PMID 15456556.
^ ^a ^b Lelis J (June 1992). "Autosomal recessive ectodermal dysplasia". Cutis. 49 (6): 435–7. PMID 1628512.
^ Steiner CE, Cintra ML, Marques-de-Faria AP (December 2002). "Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome)". Am. J. Med. Genet. 113 (4): 381–4. doi:10.1002/ajmg.b.10787. PMID 12457412.

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