LIMA1

LIMA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8Y
Identifiers
Aliases	LIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
External IDs	OMIM: 608364; MGI: 1920992; HomoloGene: 9484; GeneCards: LIMA1; OMA:LIMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,283,546 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,773,337 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; tendon of biceps brachii; ; Achilles tendon; ; rectum; ; mucosa of colon; ; mucosa of sigmoid colon; ; subcutaneous adipose tissue; ; jejunal mucosa; ; gastric mucosa;
	Top expressed in
	genital tubercle; ; lacrimal gland; ; transitional epithelium of urinary bladder; ; Rostral migratory stream; ; left colon; ; epithelium of stomach; ; lobe of prostate; ; duodenum; ; pyloric antrum; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; actin binding; actin monomer binding; protein binding; metal ion binding; cadherin binding;
Cellular component	cell junction; cleavage furrow; cytoskeleton; brush border; stress fiber; focal adhesion; actin cytoskeleton; cytoplasm;
Biological process	negative regulation of actin filament depolymerization; ruffle organization; actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologs
	51474
	65970
	ENSG00000050405
	ENSMUSG00000023022
	Q9UHB6
	Q9ERG0
	NM_001113546; NM_001113547; NM_001243775; NM_016357
	NM_001113545; NM_023063
	NP_001107018; NP_001107019; NP_001230704; NP_057441
	NP_001107017; NP_075550
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.^[5]^[6]^[7]^[8]

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000050405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1–2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID 10806352.1–2&rft.pages=69-76&rft.date=2000-07&rft_id=info:doi/10.1016/S0378-1119(00)00144-X&rft_id=info:pmid/10806352&rft.aulast=Chen&rft.aufirst=S&rft.au=Maul, RS&rft.au=Kim, HR&rft.au=Chang, DD&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
^ Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838–41. doi:10.1038/sj.onc.1203206. PMID 10618726.7838-41&rft.date=2000-02&rft_id=info:doi/10.1038/sj.onc.1203206&rft_id=info:pmid/10618726&rft.aulast=Maul&rft.aufirst=RS&rft.au=Chang, DD&rft_id=https://doi.org/10.1038%2Fsj.onc.1203206&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
^ Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol. 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC 2172667. PMID 12566430.399-407&rft.date=2003-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172667#id-name=PMC&rft_id=info:pmid/12566430&rft_id=info:doi/10.1083/jcb.200212057&rft.aulast=Maul&rft.aufirst=RS&rft.au=Song, Y&rft.au=Amann, KJ&rft.au=Gerbin, SC&rft.au=Pollard, TD&rft.au=Chang, DD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172667&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
^ ^a ^b "Entrez Gene: LIMA1 LIM domain and actin binding 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.9543-8&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16901#id-name=PMC&rft_id=info:pmid/10931946&rft_id=info:doi/10.1073/pnas.160270997&rft_id=info:bibcode/2000PNAS...97.9543H&rft.aulast=Hu&rft.aufirst=RM&rft.au=Han, ZG&rft.au=Song, HD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16901&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.422-35&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072#id-name=PMC&rft_id=info:pmid/11230166&rft_id=info:doi/10.1101/gr.GR1547R&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Weil, B&rft.au=Wellenreuther, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.287-92&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732#id-name=PMC&rft_id=info:pmid/11256614&rft_id=info:doi/10.1093/embo-reports/kvd058&rft.aulast=Simpson&rft.aufirst=JC&rft.au=Wellenreuther, R&rft.au=Poustka, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.12130-5&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446#id-name=PMC&rft_id=info:pmid/15302935&rft_id=info:doi/10.1073/pnas.0404720101&rft_id=info:bibcode/2004PNAS..10112130B&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski, M&rft.au=Schwartz, D&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.1436-50&rft.date=2004&rft_id=info:doi/10.1016/j.cub.2004.07.051&rft_id=https://api.semanticscholar.org/CorpusID:2371325#id-name=S2CID&rft_id=info:pmid/15324660&rft_id=info:bibcode/2004CBio...14.1436J&rft.aulast=Jin&rft.aufirst=J&rft.au=Smith, FD&rft.au=Stark, C&rft_id=https://doi.org/10.1016%2Fj.cub.2004.07.051&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.15724-9&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524842#id-name=PMC&rft_id=info:pmid/15498874&rft_id=info:doi/10.1073/pnas.0404089101&rft_id=info:bibcode/2004PNAS..10115724W&rft.aulast=Wan&rft.aufirst=D&rft.au=Gong, Y&rft.au=Qin, W&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524842&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.94-101&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:7200157#id-name=S2CID&rft_id=info:pmid/15592455&rft_id=info:doi/10.1038/nbt1046&rft.aulast=Rush&rft.aufirst=J&rft.au=Moritz, A&rft.au=Lee, KA&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.1339-46&rft.date=2005&rft_id=info:doi/10.1021/pr050048h&rft_id=info:pmid/16083285&rft.aulast=Kim&rft.aufirst=JE&rft.au=Tannenbaum, SR&rft.au=White, FM&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.5391-6&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365#id-name=PMC&rft_id=info:pmid/16565220&rft_id=info:doi/10.1073/pnas.0507066103&rft_id=info:bibcode/2006PNAS..103.5391N&rft.aulast=Nousiainen&rft.aufirst=M&rft.au=Silljé, HH&rft.au=Sauer, G&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000050405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10806352-5] Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1–2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID 10806352.1–2&rft.pages=69-76&rft.date=2000-07&rft_id=info:doi/10.1016/S0378-1119(00)00144-X&rft_id=info:pmid/10806352&rft.aulast=Chen&rft.aufirst=S&rft.au=Maul, RS&rft.au=Kim, HR&rft.au=Chang, DD&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">

[pmid10618726-6] Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838–41. doi:10.1038/sj.onc.1203206. PMID 10618726.7838-41&rft.date=2000-02&rft_id=info:doi/10.1038/sj.onc.1203206&rft_id=info:pmid/10618726&rft.aulast=Maul&rft.aufirst=RS&rft.au=Chang, DD&rft_id=https://doi.org/10.1038%2Fsj.onc.1203206&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">

[pmid12566430-7] Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol. 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC 2172667. PMID 12566430.399-407&rft.date=2003-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172667#id-name=PMC&rft_id=info:pmid/12566430&rft_id=info:doi/10.1083/jcb.200212057&rft.aulast=Maul&rft.aufirst=RS&rft.au=Song, Y&rft.au=Amann, KJ&rft.au=Gerbin, SC&rft.au=Pollard, TD&rft.au=Chang, DD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172667&rfr_id=info:sid/en.wikipedia.org:LIMA1" class="Z3988">

[entrez-8] "Entrez Gene: LIMA1 LIM domain and actin binding 1".

[5]

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[7]

[8]

[1]

[2]

[3]

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LIMA1

References

Further reading