Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.[3][4]
This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[4]
References
edit- ^ a b c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.8–9&rft.pages=703-13&rft.date=2000-09&rft_id=https://api.semanticscholar.org/CorpusID:20719684#id-name=S2CID&rft_id=info:pmid/10941842&rft_id=info:doi/10.1007/s002510000187&rft.aulast=Wende&rft.aufirst=H&rft.au=Volz, A&rft.au=Ziegler, A&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- ^ a b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".
Further reading
edit- Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi:10.1093/intimm/dxm127. PMID 18048391.155-64&rft.date=2008&rft_id=info:doi/10.1093/intimm/dxm127&rft_id=info:pmid/18048391&rft.aulast=Cho&rft.aufirst=M&rft.au=Ishida, K&rft.au=Chen, J&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi:10.1182/blood-2007-08-110130. PMID 18006695.1625-33&rft.date=2008&rft_id=info:doi/10.1182/blood-2007-08-110130&rft_id=info:pmid/18006695&rft.aulast=Sellick&rft.aufirst=GS&rft.au=Wade, R&rft.au=Richards, S&rft_id=https://doi.org/10.1182%2Fblood-2007-08-110130&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.279-89&rft.date=2006&rft_id=info:doi/10.1016/j.ab.2006.05.024&rft_id=info:pmid/16777052&rft.aulast=Zhan&rft.aufirst=X&rft.au=Desiderio, DM&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323. PMID 16735691.1399-405&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118323#id-name=PMC&rft_id=info:pmid/16735691&rft_id=info:doi/10.1084/jem.20052454&rft.aulast=Cao&rft.aufirst=W&rft.au=Rosen, DB&rft.au=Ito, T&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118323&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.159-64&rft.date=2004&rft_id=info:doi/10.1016/j.gene.2004.02.018&rft_id=info:pmid/15094202&rft.aulast=Ju&rft.aufirst=XS&rft.au=Hacker, C&rft.au=Scherer, B&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.1174-9&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC298746#id-name=PMC&rft_id=info:pmid/12529506&rft_id=info:doi/10.1073/pnas.0337567100&rft_id=info:bibcode/2003PNAS..100.1174T&rft.aulast=Tedla&rft.aufirst=N&rft.au=Bandeira-Melo, C&rft.au=Tassinari, P&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC298746&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi:10.1182/blood-2002-02-0638. PMID 12384430.3295-303&rft.date=2002&rft_id=info:doi/10.1182/blood-2002-02-0638&rft_id=info:pmid/12384430&rft.aulast=Rissoan&rft.aufirst=MC&rft.au=Duhen, T&rft.au=Bridon, JM&rft_id=https://doi.org/10.1182%2Fblood-2002-02-0638&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">
- Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.270-8&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:2819935#id-name=S2CID&rft_id=info:pmid/11491530&rft_id=info:doi/10.1007/s002510100332&rft.aulast=Young&rft.aufirst=NT&rft.au=Canavez, F&rft.au=Uhrberg, M&rfr_id=info:sid/en.wikipedia.org:LILRA4" class="Z3988">