LGMN

LGMN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N6N, 4N6O, 4FGU, 4AWB, 4AWA, 4AW9
Identifiers
Aliases	LGMN, AEP, LGMN1, PRSC1, legumain
External IDs	OMIM: 602620; MGI: 1330838; HomoloGene: 38075; GeneCards: LGMN; OMA:LGMN - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	92,748,679 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,406,072 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; gallbladder; ; synovial membrane; ; right coronary artery; ; left lobe of thyroid gland; ; placenta; ; rectum; ; right lobe of thyroid gland; ; spleen; ; oocyte;
	Top expressed in
	stroma of bone marrow; ; yolk sac; ; right kidney; ; human kidney; ; neural layer of retina; ; calvaria; ; decidua; ; saccule; ; proximal tubule; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; hydrolase activity; cysteine-type endopeptidase activity; tau protein binding;
Cellular component	late endosome; apical part of cell; lysosomal lumen; lysosome; extracellular exosome; endolysosome lumen; extracellular region; cytoplasm; perinuclear region of cytoplasm;
Biological process	negative regulation of neuron apoptotic process; negative regulation of ERBB signaling pathway; renal system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; vitamin D metabolic process; negative regulation of multicellular organism growth; vacuolar protein processing; receptor catabolic process; proteolysis; toll-like receptor signaling pathway; proteolysis involved in cellular protein catabolic process; response to acidic pH; memory; positive regulation of cell population proliferation; associative learning; negative regulation of gene expression; cellular response to hepatocyte growth factor stimulus; positive regulation of mitotic cell cycle; cellular response to calcium ion; positive regulation of monocyte chemotaxis; dendritic spine organization; activation of cysteine-type endopeptidase activity; self proteolysis; positive regulation of long-term synaptic potentiation; cellular response to amyloid-beta; positive regulation of endothelial cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	5641
	19141
	ENSG00000100600
	ENSMUSG00000021190
	Q99538
	O89017
	NM_001008530; NM_005606; NM_001363696; NM_001363699
	NM_011175; NM_001378875
	NP_001008530; NP_005597; NP_001350625; NP_001350628
	NP_035305; NP_001365804
	Wikidata
View/Edit Human	View/Edit Mouse

Legumain is a protein that in humans is encoded by the LGMN gene.^[5]^[6]^[7]

This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021190 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanaka T, Inazawa J, Nakamura Y (Dec 1996). "Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1". Cytogenet Cell Genet. 74 (1–2): 120–3. doi:10.1159/000134397. PMID 8893817.1–2&rft.pages=120-3&rft.date=1996-12&rft_id=info:doi/10.1159/000134397&rft_id=info:pmid/8893817&rft.aulast=Tanaka&rft.aufirst=T&rft.au=Inazawa, J&rft.au=Nakamura, Y&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
^ Chen JM, Dando PM, Rawlings ND, Brown MA, Young NE, Stevens RA, Hewitt E, Watts C, Barrett AJ (Apr 1997). "Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase". J Biol Chem. 272 (12): 8090–8. doi:10.1074/jbc.272.12.8090. PMID 9065484.8090-8&rft.date=1997-04&rft_id=info:doi/10.1074/jbc.272.12.8090&rft_id=info:pmid/9065484&rft.aulast=Chen&rft.aufirst=JM&rft.au=Dando, PM&rft.au=Rawlings, ND&rft.au=Brown, MA&rft.au=Young, NE&rft.au=Stevens, RA&rft.au=Hewitt, E&rft.au=Watts, C&rft.au=Barrett, AJ&rft_id=https://doi.org/10.1074%2Fjbc.272.12.8090&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
^ ^a ^b "Entrez Gene: LGMN legumain".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.au=Suzuki Y&rft.au=Yoshitomo-Nakagawa K&rft.au=Maruyama K&rft.au=Suyama, A&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Chen JM, Dando PM, Stevens RA, et al. (1998). "Cloning and expression of mouse legumain, a lysosomal endopeptidase". Biochem. J. 335 (Pt 1): 111–7. doi:10.1042/bj3350111. PMC 1219758. PMID 9742219.111-7&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219758#id-name=PMC&rft_id=info:pmid/9742219&rft_id=info:doi/10.1042/bj3350111&rft.au=Chen JM&rft.au=Dando PM&rft.au=Stevens RA&rft.au=Fortunato, M&rft.au=Barrett, AJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219758&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Halfon S, Patel S, Vega F, et al. (1998). "Autocatalytic activation of human legumain at aspartic acid residues". FEBS Lett. 438 (1–2): 114–8. doi:10.1016/S0014-5793(98)01281-2. PMID 9821970. S2CID 32702742.1–2&rft.pages=114-8&rft.date=1998&rft_id=https://api.semanticscholar.org/CorpusID:32702742#id-name=S2CID&rft_id=info:pmid/9821970&rft_id=info:doi/10.1016/S0014-5793(98)01281-2&rft.au=Halfon S&rft.au=Patel S&rft.au=Vega F&rft.au=Zurawski, S&rft.au=Zurawski, G&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Manoury B, Hewitt EW, Morrice N, et al. (1999). "An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation". Nature. 396 (6712): 695–9. doi:10.1038/25379. PMID 9872320. S2CID 4352065.695-9&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:4352065#id-name=S2CID&rft_id=info:pmid/9872320&rft_id=info:doi/10.1038/25379&rft.au=Manoury B&rft.au=Hewitt EW&rft.au=Morrice N&rft.au=Morrice, Nick&rft.au=Dando, Pam M.&rft.au=Barrett, Alan J.&rft_id=https://doi.org/10.1038%2F25379&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Chen JM, Rawlings ND, Stevens RA, Barrett AJ (1999). "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases". FEBS Lett. 441 (3): 361–5. doi:10.1016/S0014-5793(98)01574-9. PMID 9891971. S2CID 46043484.361-5&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:46043484#id-name=S2CID&rft_id=info:pmid/9891971&rft_id=info:doi/10.1016/S0014-5793(98)01574-9&rft.aulast=Chen&rft.aufirst=JM&rft.au=Rawlings, ND&rft.au=Stevens, RA&rft.au=Barrett, AJ&rft_id=https://doi.org/10.1016%2FS0014-5793%2898%2901574-9&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Chen JM, Fortunato M, Barrett AJ (2001). "Activation of human prolegumain by cleavage at a C-terminal asparagine residue". Biochem. J. 352 (2): 327–34. doi:10.1042/bj3520327. PMC 1221463. PMID 11085925.327-34&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221463#id-name=PMC&rft_id=info:pmid/11085925&rft_id=info:doi/10.1042/bj3520327&rft.aulast=Chen&rft.aufirst=JM&rft.au=Fortunato, M&rft.au=Barrett, AJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221463&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg RL&rft.au=Feingold EA&rft.au=Grouse LH&rft.au=Derge, JG&rft.au=Klausner, RD&rft.au=Collins, FS&rft.au=Wagner, L&rft.au=Shenmen, CM&rft.au=Schuler, GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Li DN, Matthews SP, Antoniou AN, et al. (2003). "Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo". J. Biol. Chem. 278 (40): 38980–90. doi:10.1074/jbc.M305930200. PMID 12860980.38980-90&rft.date=2003&rft_id=info:doi/10.1074/jbc.M305930200&rft_id=info:pmid/12860980&rft.au=Li DN&rft.au=Matthews SP&rft.au=Antoniou AN&rft.au=Mazzeo, D&rft.au=Watts, C&rft_id=https://doi.org/10.1074%2Fjbc.M305930200&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Burster T, Beck A, Tolosa E, et al. (2004). "Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes". J. Immunol. 172 (9): 5495–503. doi:10.4049/jimmunol.172.9.5495. PMID 15100291.5495-503&rft.date=2004&rft_id=info:doi/10.4049/jimmunol.172.9.5495&rft_id=info:pmid/15100291&rft.au=Burster T&rft.au=Beck A&rft.au=Tolosa E&rft.au=Marin-Esteban, V&rft.au=Rötzschke, O&rft.au=Falk, K&rft.au=Lautwein, A&rft.au=Reich, M&rft.au=Brandenburg, J&rft_id=https://doi.org/10.4049%2Fjimmunol.172.9.5495&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.au=Gerhard DS&rft.au=Wagner L&rft.au=Feingold EA&rft.au=Shenmen, CM&rft.au=Grouse, LH&rft.au=Schuler, G&rft.au=Klein, SL&rft.au=Old, S&rft.au=Rasooly, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Murthy RV, Arbman G, Gao J, et al. (2005). "Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer". Clin. Cancer Res. 11 (6): 2293–9. doi:10.1158/1078-0432.CCR-04-1642. PMID 15788679.2293-9&rft.date=2005&rft_id=info:doi/10.1158/1078-0432.CCR-04-1642&rft_id=info:pmid/15788679&rft.au=Murthy RV&rft.au=Arbman G&rft.au=Gao J&rft.au=Roodman, GD&rft.au=Sun, XF&rft_id=https://doi.org/10.1158%2F1078-0432.CCR-04-1642&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.942-54&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:69278#id-name=S2CID&rft_id=info:pmid/16341674&rft_id=info:doi/10.1007/s00335-005-0075-2&rft.au=Oh JH&rft.au=Yang JO&rft.au=Hahn Y&rft.au=Kim, Mi-Rang&rft.au=Byun, Sang-Soon&rft.au=Jeon, Yeo-Jin&rft.au=Kim, Jeong-Min&rft.au=Song, Kyu-Sang&rft.au=Noh, Seung-Moo&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021190 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8893817-5] Tanaka T, Inazawa J, Nakamura Y (Dec 1996). "Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1". Cytogenet Cell Genet. 74 (1–2): 120–3. doi:10.1159/000134397. PMID 8893817.1–2&rft.pages=120-3&rft.date=1996-12&rft_id=info:doi/10.1159/000134397&rft_id=info:pmid/8893817&rft.aulast=Tanaka&rft.aufirst=T&rft.au=Inazawa, J&rft.au=Nakamura, Y&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">

[pmid9065484-6] Chen JM, Dando PM, Rawlings ND, Brown MA, Young NE, Stevens RA, Hewitt E, Watts C, Barrett AJ (Apr 1997). "Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase". J Biol Chem. 272 (12): 8090–8. doi:10.1074/jbc.272.12.8090. PMID 9065484.8090-8&rft.date=1997-04&rft_id=info:doi/10.1074/jbc.272.12.8090&rft_id=info:pmid/9065484&rft.aulast=Chen&rft.aufirst=JM&rft.au=Dando, PM&rft.au=Rawlings, ND&rft.au=Brown, MA&rft.au=Young, NE&rft.au=Stevens, RA&rft.au=Hewitt, E&rft.au=Watts, C&rft.au=Barrett, AJ&rft_id=https://doi.org/10.1074%2Fjbc.272.12.8090&rfr_id=info:sid/en.wikipedia.org:LGMN" class="Z3988">

[entrez-7] "Entrez Gene: LGMN legumain".

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[7]

[1]

[2]

[3]

[4]

LGMN

References

Further reading