L-lysine cyclodeaminase

L-lysine cyclodeaminase (EC 4.3.1.28, rapL (gene), fkbL (gene), tubZ (gene), visC (gene)) is an enzyme with systematic name L-lysine ammonia-lyase (cyclizing; ammonia-forming).[1][2][3] This enzyme catalyses the following chemical reaction

L-lysine cyclodeaminase
Identifiers
EC no.4.3.1.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
L-lysine L-pipecolate NH3

This enzyme requires bound NAD .

References

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  1. ^ Khaw LE, Böhm GA, Metcalfe S, Staunton J, Leadlay PF (February 1998). "Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase". Journal of Bacteriology. 180 (4): 809–14. PMC 106958. PMID 9473033.809-14&rft.date=1998-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC106958#id-name=PMC&rft_id=info:pmid/9473033&rft.aulast=Khaw&rft.aufirst=LE&rft.au=Böhm, GA&rft.au=Metcalfe, S&rft.au=Staunton, J&rft.au=Leadlay, PF&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC106958&rfr_id=info:sid/en.wikipedia.org:L-lysine cyclodeaminase" class="Z3988">
  2. ^ Gatto GJ, Boyne MT, Kelleher NL, Walsh CT (March 2006). "Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster". Journal of the American Chemical Society. 128 (11): 3838–47. doi:10.1021/ja0587603. PMID 16536560.3838-47&rft.date=2006-03&rft_id=info:doi/10.1021/ja0587603&rft_id=info:pmid/16536560&rft.aulast=Gatto&rft.aufirst=GJ&rft.au=Boyne, MT&rft.au=Kelleher, NL&rft.au=Walsh, CT&rfr_id=info:sid/en.wikipedia.org:L-lysine cyclodeaminase" class="Z3988">
  3. ^ Tsotsou GE, Barbirato F (May 2007). "Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase". Biochimie. 89 (5): 591–604. doi:10.1016/j.biochi.2006.12.008. PMID 17291665.591-604&rft.date=2007-05&rft_id=info:doi/10.1016/j.biochi.2006.12.008&rft_id=info:pmid/17291665&rft.aulast=Tsotsou&rft.aufirst=GE&rft.au=Barbirato, F&rfr_id=info:sid/en.wikipedia.org:L-lysine cyclodeaminase" class="Z3988">
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