KIF2A

KIF2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GRY
Identifiers
Aliases	KIF2A, CDCBM3, HK2, KIF2, kinesin heavy chain member 2A, kinesin family member 2A
External IDs	OMIM: 602591; MGI: 108390; HomoloGene: 3320; GeneCards: KIF2A; OMA:KIF2A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	62,391,025 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	107,158,634 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ganglionic eminence; ; monocyte; ; sperm; ; ventricular zone; ; external globus pallidus; ; sural nerve; ; subthalamic nucleus; ; pars compacta; ; superior vestibular nucleus;
	Top expressed in
	barrel cortex; ; blood; ; genital tubercle; ; habenula; ; tail of embryo; ; zygote; ; secondary oocyte; ; olfactory bulb; ; facial motor nucleus; ; spermatid;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; microtubule binding; ATPase activity; protein binding; cytoskeletal motor activity; ATP binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; membrane; kinesin complex; spindle; microtubule organizing center; sperm principal piece; spindle microtubule; nucleolus; microtubule; cytoskeleton; nucleus; nuclear body; centriole; centriolar subdistal appendage;
Biological process	cell differentiation; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic spindle organization; nervous system development; cell division; multicellular organism development; microtubule-based movement; mitotic spindle assembly; cell cycle; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; sister chromatid cohesion; microtubule cytoskeleton organization; microtubule depolymerization; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	3796
	16563
	ENSG00000068796
	ENSMUSG00000021693
	O00139
	P28740
	NM_004520; NM_001098511; NM_001243952; NM_001243953
NM_001145779; NM_008442; NM_001374727; NM_001378936; NM_001378937;
	NM_001378938; NM_001378939; NM_001378940
	NP_001091981; NP_001230881; NP_001230882; NP_004511
NP_001139251; NP_032468; NP_001361656; NP_001365865; NP_001365866;
	NP_001365867; NP_001365868; NP_001365869
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.^[5]^[6] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.^[7]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.67-73&rft.date=1997-05&rft_id=info:doi/10.1006/geno.1997.4720&rft_id=info:pmid/9177777&rft.aulast=Debernardi&rft.aufirst=S&rft.au=Fontanella, E&rft.au=De Gregorio, L&rft.au=Pierotti, MA&rft.au=Delia, D&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
^ ^a ^b "Entrez Gene: KIF2A kinesin heavy chain member 2A".
^ Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46): e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA (August 2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells". Molecular Biology of the Cell. 18 (8): 2970–2979. doi:10.1091/mbc.E07-02-0110. PMC 1949365. PMID 17538014.2970-2979&rft.date=2007-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949365#id-name=PMC&rft_id=info:pmid/17538014&rft_id=info:doi/10.1091/mbc.E07-02-0110&rft.aulast=Manning&rft.aufirst=AL&rft.au=Ganem, NJ&rft.au=Bakhoum, SF&rft.au=Wagenbach, M&rft.au=Wordeman, L&rft.au=Compton, DA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949365&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Schepis A, Stauber T, Krijnse Locker J (August 2007). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle". Cellular Microbiology. 9 (8): 1960–1973. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562. S2CID 23205204.1960-1973&rft.date=2007-08&rft_id=https://api.semanticscholar.org/CorpusID:23205204#id-name=S2CID&rft_id=info:pmid/17394562&rft_id=info:doi/10.1111/j.1462-5822.2007.00927.x&rft.aulast=Schepis&rft.aufirst=A&rft.au=Stauber, T&rft.au=Krijnse Locker, J&rft_id=https://doi.org/10.1111%2Fj.1462-5822.2007.00927.x&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Li C, Zheng Y, Qin W, Tao R, Pan Y, Xu Y, et al. (October 2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia". Neuroscience Letters. 407 (2): 151–155. doi:10.1016/j.neulet.2006.08.025. PMID 16986319. S2CID 32742823.151-155&rft.date=2006-10&rft_id=https://api.semanticscholar.org/CorpusID:32742823#id-name=S2CID&rft_id=info:pmid/16986319&rft_id=info:doi/10.1016/j.neulet.2006.08.025&rft.aulast=Li&rft.aufirst=C&rft.au=Zheng, Y&rft.au=Qin, W&rft.au=Tao, R&rft.au=Pan, Y&rft.au=Xu, Y&rft.au=Li, X&rft.au=Gu, N&rft.au=Feng, G&rft.au=He, L&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.5391-5396&rft.date=2006-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365#id-name=PMC&rft_id=info:pmid/16565220&rft_id=info:doi/10.1073/pnas.0507066103&rft_id=info:bibcode/2006PNAS..103.5391N&rft.aulast=Nousiainen&rft.aufirst=M&rft.au=Silljé, HH&rft.au=Sauer, G&rft.au=Nigg, EA&rft.au=Körner, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Ganem NJ, Upton K, Compton DA (October 2005). "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology. 15 (20): 1827–1832. Bibcode:2005CBio...15.1827G. doi:10.1016/j.cub.2005.08.065. PMID 16243029. S2CID 8541946.1827-1832&rft.date=2005-10&rft_id=info:doi/10.1016/j.cub.2005.08.065&rft_id=https://api.semanticscholar.org/CorpusID:8541946#id-name=S2CID&rft_id=info:pmid/16243029&rft_id=info:bibcode/2005CBio...15.1827G&rft.aulast=Ganem&rft.aufirst=NJ&rft.au=Upton, K&rft.au=Compton, DA&rft_id=https://doi.org/10.1016%2Fj.cub.2005.08.065&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Ganem NJ, Compton DA (August 2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology. 166 (4): 473–478. doi:10.1083/jcb.200404012. PMC 2172212. PMID 15302853.473-478&rft.date=2004-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172212#id-name=PMC&rft_id=info:pmid/15302853&rft_id=info:doi/10.1083/jcb.200404012&rft.aulast=Ganem&rft.aufirst=NJ&rft.au=Compton, DA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172212&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">
Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. (December 2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–2144. Bibcode:2003Sci...302.2141J. CiteSeerX 10.1.1.1017.9438. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.2141-2144&rft.date=2003-12&rft_id=https://api.semanticscholar.org/CorpusID:10007258#id-name=S2CID&rft_id=info:bibcode/2003Sci...302.2141J&rft_id=https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1017.9438#id-name=CiteSeerX&rft_id=info:pmid/14684825&rft_id=info:doi/10.1126/science.1090100&rft.aulast=Johnson&rft.aufirst=JM&rft.au=Castle, J&rft.au=Garrett-Engele, P&rft.au=Kan, Z&rft.au=Loerch, PM&rft.au=Armour, CD&rft.au=Santos, R&rft.au=Schadt, EE&rft.au=Stoughton, R&rft.au=Shoemaker, DD&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">

External links

Overview of all the structural information available in the PDB for UniProt: O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9177777-5] Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.67-73&rft.date=1997-05&rft_id=info:doi/10.1006/geno.1997.4720&rft_id=info:pmid/9177777&rft.aulast=Debernardi&rft.aufirst=S&rft.au=Fontanella, E&rft.au=De Gregorio, L&rft.au=Pierotti, MA&rft.au=Delia, D&rfr_id=info:sid/en.wikipedia.org:KIF2A" class="Z3988">

[entrez-6] "Entrez Gene: KIF2A kinesin heavy chain member 2A".

[7] Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46): e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.

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[7]

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KIF2A

References

Further reading

External links