Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18gene. K2P18.1 is a potassium channel containing two pore-forming P domains.[5]
A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID16382106. S2CID7356601.527-40&rft.date=2005-12&rft_id=https://api.semanticscholar.org/CorpusID:7356601#id-name=S2CID&rft_id=info:pmid/16382106&rft_id=info:doi/10.1124/pr.57.4.12&rft.aulast=Goldstein&rft.aufirst=SA&rft.au=Bayliss, DA&rft.au=Kim, D&rft.au=Lesage, F&rft.au=Plant, LD&rft.au=Rajan, S&rft_id=https://escholarship.org/uc/item/3k15p5vt&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
^Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine. 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID20871611. S2CID205387180.1157-1160&rft.date=2010-09&rft_id=https://api.semanticscholar.org/CorpusID:205387180#id-name=S2CID&rft_id=info:pmid/20871611&rft_id=info:doi/10.1038/nm.2216&rft.aulast=Lafrenière&rft.aufirst=RG&rft.au=Cader, MZ&rft.au=Poulin, JF&rft.au=Andres-Enguix, I&rft.au=Simoneau, M&rft.au=Gupta, N&rft.au=Boisvert, K&rft.au=Lafrenière, F&rft.au=McLaughlan, S&rft.au=Dubé, MP&rft.au=Marcinkiewicz, MM&rft.au=Ramagopalan, S&rft.au=Ansorge, O&rft.au=Brais, B&rft.au=Sequeiros, J&rft.au=Pereira-Monteiro, JM&rft.au=Griffiths, LR&rft.au=Tucker, SJ&rft.au=Ebers, G&rft.au=Rouleau, GA&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID15761153. S2CID39457788.1621-5&rft.date=2005&rft_id=info:doi/10.1126/science.1105776&rft_id=https://api.semanticscholar.org/CorpusID:39457788#id-name=S2CID&rft_id=info:pmid/15761153&rft_id=info:bibcode/2005Sci...307.1621B&rft.aulast=Barrios-Rodiles&rft.aufirst=M&rft.au=Brown, KR&rft.au=Ozdamar, B&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
Czirják G, Vuity D, Enyedi P (2008). "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation". J. Biol. Chem. 283 (23): 15672–80. doi:10.1074/jbc.M800712200. PMC3259650. PMID18397886.15672-80&rft.date=2008&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259650#id-name=PMC&rft_id=info:pmid/18397886&rft_id=info:doi/10.1074/jbc.M800712200&rft.aulast=Czirják&rft.aufirst=G&rft.au=Vuity, D&rft.au=Enyedi, P&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259650&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
Pottosin II, Bonales-Alatorre E, Valencia-Cruz G, et al. (2008). "TRESK-like potassium channels in leukemic T cells". Pflügers Arch. 456 (6): 1037–48. doi:10.1007/s00424-008-0481-x. PMID18506476. S2CID3245155.1037-48&rft.date=2008&rft_id=https://api.semanticscholar.org/CorpusID:3245155#id-name=S2CID&rft_id=info:pmid/18506476&rft_id=info:doi/10.1007/s00424-008-0481-x&rft.aulast=Pottosin&rft.aufirst=II&rft.au=Bonales-Alatorre, E&rft.au=Valencia-Cruz, G&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
Sano Y, Inamura K, Miyake A, et al. (2003). "A novel two-pore domain K channel, TRESK, is localized in the spinal cord". J. Biol. Chem. 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID12754259.27406-12&rft.date=2003&rft_id=info:doi/10.1074/jbc.M206810200&rft_id=info:pmid/12754259&rft.aulast=Sano&rft.aufirst=Y&rft.au=Inamura, K&rft.au=Miyake, A&rft_id=https://doi.org/10.1074%2Fjbc.M206810200&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">