Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.[5]

KCNK18
Identifiers
AliasesKCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDsOMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181840

NM_207261

RefSeq (protein)

NP_862823

NP_997144

Location (UCSC)Chr 10: 117.2 – 117.21 MbChr 19: 59.21 – 59.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186795Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040901Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.527-40&rft.date=2005-12&rft_id=https://api.semanticscholar.org/CorpusID:7356601#id-name=S2CID&rft_id=info:pmid/16382106&rft_id=info:doi/10.1124/pr.57.4.12&rft.aulast=Goldstein&rft.aufirst=SA&rft.au=Bayliss, DA&rft.au=Kim, D&rft.au=Lesage, F&rft.au=Plant, LD&rft.au=Rajan, S&rft_id=https://escholarship.org/uc/item/3k15p5vt&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">
  6. ^ Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine. 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID 20871611. S2CID 205387180.1157-1160&rft.date=2010-09&rft_id=https://api.semanticscholar.org/CorpusID:205387180#id-name=S2CID&rft_id=info:pmid/20871611&rft_id=info:doi/10.1038/nm.2216&rft.aulast=Lafrenière&rft.aufirst=RG&rft.au=Cader, MZ&rft.au=Poulin, JF&rft.au=Andres-Enguix, I&rft.au=Simoneau, M&rft.au=Gupta, N&rft.au=Boisvert, K&rft.au=Lafrenière, F&rft.au=McLaughlan, S&rft.au=Dubé, MP&rft.au=Marcinkiewicz, MM&rft.au=Ramagopalan, S&rft.au=Ansorge, O&rft.au=Brais, B&rft.au=Sequeiros, J&rft.au=Pereira-Monteiro, JM&rft.au=Griffiths, LR&rft.au=Tucker, SJ&rft.au=Ebers, G&rft.au=Rouleau, GA&rfr_id=info:sid/en.wikipedia.org:KCNK18" class="Z3988">

Further reading

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