Ixoberogene soroparvovec (Ixo-vec, also known as ADVM-022), is a gene therapy developed by Adverum Biotechnologies for wet age-related macular degeneration. It is delivered via the viral vector AAV.7m8.[1][2]
References
edit- ^ Gelfman, Claire M.; Grishanin, Ruslan; Bender, Kristina Oresic; Nguyen, Aivan; Greengard, Judith; Sharma, Pallavi; Nieves, Julio; Kiss, Szilárd; Gasmi, Mehdi (2021-04-01). "Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema". Journal of Ocular Pharmacology and Therapeutics. 37 (3): 181–190. doi:10.1089/jop.2021.0001. ISSN 1080-7683. PMC 8060718. PMID 33835848.181-190&rft.date=2021-04-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060718#id-name=PMC&rft.issn=1080-7683&rft_id=info:pmid/33835848&rft_id=info:doi/10.1089/jop.2021.0001&rft.aulast=Gelfman&rft.aufirst=Claire M.&rft.au=Grishanin, Ruslan&rft.au=Bender, Kristina Oresic&rft.au=Nguyen, Aivan&rft.au=Greengard, Judith&rft.au=Sharma, Pallavi&rft.au=Nieves, Julio&rft.au=Kiss, Szilárd&rft.au=Gasmi, Mehdi&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060718&rfr_id=info:sid/en.wikipedia.org:Ixoberogene soroparvovec" class="Z3988">
- ^ Grishanin, Ruslan; Vuillemenot, Brian; Sharma, Pallavi; Keravala, Annahita; Greengard, Judith; Gelfman, Claire; Blumenkrantz, Mark; Lawrence, Matthew; Hu, Wenzheng; Kiss, Szilárd; Gasmi, Mehdi (January 2019). "Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration". Molecular Therapy. 27 (1): 118–129. doi:10.1016/j.ymthe.2018.11.003. PMC 6319194. PMID 30528929.118-129&rft.date=2019-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319194#id-name=PMC&rft_id=info:pmid/30528929&rft_id=info:doi/10.1016/j.ymthe.2018.11.003&rft.aulast=Grishanin&rft.aufirst=Ruslan&rft.au=Vuillemenot, Brian&rft.au=Sharma, Pallavi&rft.au=Keravala, Annahita&rft.au=Greengard, Judith&rft.au=Gelfman, Claire&rft.au=Blumenkrantz, Mark&rft.au=Lawrence, Matthew&rft.au=Hu, Wenzheng&rft.au=Kiss, Szilárd&rft.au=Gasmi, Mehdi&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319194&rfr_id=info:sid/en.wikipedia.org:Ixoberogene soroparvovec" class="Z3988">