Isoeugenol synthase (EC 1.1.1.319, IGS1, t-anol/isoeugenol synthase 1) is an enzyme with systematic name eugenol:NADP oxidoreductase (coniferyl acetate reducing).[1][2][3] This enzyme catalyses the following chemical reaction.[4]
| Isoeugenol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.319 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- isoeugenol acetate NADP coniferyl acetate NADPH H
The enzyme acts in the reverse direction.
Dexter et al., 2007 finds that the substrate is coniferyl acetate.[5]
References
edit- ^ Koeduka T, Fridman E, Gang DR, Vassão DG, Jackson BL, Kish CM, Orlova I, Spassova SM, Lewis NG, Noel JP, Baiga TJ, Dudareva N, Pichersky E (June 2006). "Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester". Proceedings of the National Academy of Sciences of the United States of America. 103 (26): 10128–33. doi:10.1073/pnas.0603732103. PMC 1502517. PMID 16782809.10128-33&rft.date=2006-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502517#id-name=PMC&rft_id=info:pmid/16782809&rft_id=info:doi/10.1073/pnas.0603732103&rft.aulast=Koeduka&rft.aufirst=T&rft.au=Fridman, E&rft.au=Gang, DR&rft.au=Vassão, DG&rft.au=Jackson, BL&rft.au=Kish, CM&rft.au=Orlova, I&rft.au=Spassova, SM&rft.au=Lewis, NG&rft.au=Noel, JP&rft.au=Baiga, TJ&rft.au=Dudareva, N&rft.au=Pichersky, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502517&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
- ^ Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel JP, Dudareva N, Pichersky E (May 2008). "The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages". The Plant Journal. 54 (3): 362–74. doi:10.1111/j.1365-313X.2008.03412.x. PMC 2741023. PMID 18208524.362-74&rft.date=2008-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741023#id-name=PMC&rft_id=info:pmid/18208524&rft_id=info:doi/10.1111/j.1365-313X.2008.03412.x&rft.aulast=Koeduka&rft.aufirst=T&rft.au=Louie, GV&rft.au=Orlova, I&rft.au=Kish, CM&rft.au=Ibdah, M&rft.au=Wilkerson, CG&rft.au=Bowman, ME&rft.au=Baiga, TJ&rft.au=Noel, JP&rft.au=Dudareva, N&rft.au=Pichersky, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741023&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
- ^ Koeduka T, Baiga TJ, Noel JP, Pichersky E (January 2009). "Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain". Plant Physiology. 149 (1): 384–94. doi:10.1104/pp.108.128066. PMC 2613694. PMID 18987218.384-94&rft.date=2009-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613694#id-name=PMC&rft_id=info:pmid/18987218&rft_id=info:doi/10.1104/pp.108.128066&rft.aulast=Koeduka&rft.aufirst=T&rft.au=Baiga, TJ&rft.au=Noel, JP&rft.au=Pichersky, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613694&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
- ^ Gupta AK, Schauvinhold I, Pichersky E, Schiestl FP (December 2014). "Eugenol synthase genes in floral scent variation in Gymnadenia species" (PDF). Functional & Integrative Genomics. 14 (4): 779–88. doi:10.1007/s10142-014-0397-9. hdl:20.500.11850/91540. PMID 25239559. S2CID 17207240.779-88&rft.date=2014-12&rft_id=info:hdl/20.500.11850/91540&rft_id=https://api.semanticscholar.org/CorpusID:17207240#id-name=S2CID&rft_id=info:pmid/25239559&rft_id=info:doi/10.1007/s10142-014-0397-9&rft.aulast=Gupta&rft.aufirst=AK&rft.au=Schauvinhold, I&rft.au=Pichersky, E&rft.au=Schiestl, FP&rft_id=https://www.zora.uzh.ch/id/eprint/104915/8/ZORA_NL_104915.pdf&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
- ^
- Vogt, Thomas (2010). "Phenylpropanoid Biosynthesis". Molecular Plant. 3 (1): 2–20. doi:10.1093/mp/ssp106. PMID 20035037. S2CID 39503278.2-20&rft.date=2010&rft_id=https://api.semanticscholar.org/CorpusID:39503278#id-name=S2CID&rft_id=info:pmid/20035037&rft_id=info:doi/10.1093/mp/ssp106&rft.aulast=Vogt&rft.aufirst=Thomas&rft_id=https://doi.org/10.1093%2Fmp%2Fssp106&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
- This review cites this research.
- Dexter, Richard; Qualley, Anthony; Kish, Christine M.; Ma, Choong Je; Koeduka, Takao; Nagegowda, Dinesh A.; Dudareva, Natalia; Pichersky, Eran; Clark, David (2006-12-07). "Characterization of a petunia acetyltransferase involved in the biosynthesis of the floral volatile isoeugenol". The Plant Journal. 49 (2): 265–275. doi:10.1111/j.1365-313x.2006.02954.x. hdl:2027.42/74478. PMID 17241449. S2CID 6714361.265-275&rft.date=2006-12-07&rft_id=info:hdl/2027.42/74478&rft_id=https://api.semanticscholar.org/CorpusID:6714361#id-name=S2CID&rft_id=info:pmid/17241449&rft_id=info:doi/10.1111/j.1365-313x.2006.02954.x&rft.aulast=Dexter&rft.aufirst=Richard&rft.au=Qualley, Anthony&rft.au=Kish, Christine M.&rft.au=Ma, Choong Je&rft.au=Koeduka, Takao&rft.au=Nagegowda, Dinesh A.&rft.au=Dudareva, Natalia&rft.au=Pichersky, Eran&rft.au=Clark, David&rfr_id=info:sid/en.wikipedia.org:Isoeugenol synthase" class="Z3988">
External links
edit- Isoeugenol synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
