Iscartrelvir

Iscartrelvir
Clinical data
Other names	WPV01; WU-04
Identifiers
	IUPAC name N-[(1S,2R)-2-[4-bromo-2-(methylcarbamoyl)-6-nitroanilino]cyclohexyl]isoquinoline-4-carboxamide;
CAS Number	2921711-74-0;
PubChem CID	156774920;
ChemSpider	129307041;
UNII	W2LTV65R5E;
PDB ligand	J7R (PDBe, RCSB PDB);
Chemical and physical data
Formula	C24H24BrN5O4
Molar mass	526.391 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC(=O)C1=C(C(=CC(=C1)Br)[N ](=O)[O-])N[C@@H]2CCCC[C@@H]2NC(=O)C3=CN=CC4=CC=CC=C43;
	InChI InChI=InChI=1S/C24H24BrN5O4/c1-26-23(31)17-10-15(25)11-21(30(33)34)22(17)28-19-8-4-5-9-20(19)29-24(32)18-13-27-12-14-6-2-3-7-16(14)18/h2-3,6-7,10-13,19-20,28H,4-5,8-9H2,1H3,(H,26,31)(H,29,32)/t19-,20 /m1/s1; Key:BPLNOSFMIIASSJ-UXHICEINSA-N;

Iscartrelvir is an investigational new drug developed by the Westlake University for the treatment of COVID-19. It targets the SARS-CoV-2 3CL protease, which is crucial for the replication of the virus responsible for COVID-19.^[1]^[2]

References

^ Yang L, Wang Z (September 2023). "Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China". European Journal of Medicinal Chemistry. 257: 115503. doi:10.1016/j.ejmech.2023.115503. PMC 10193775. PMID 37229831.
^ Hou N, Shuai L, Zhang L, Xie X, Tang K, Zhu Y, et al. (February 2023). "Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro". ACS Central Science. 9 (2): 217–227. doi:10.1021/acscentsci.2c01359. PMC 9885526. PMID 36844503.217-227&rft.date=2023-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885526#id-name=PMC&rft_id=info:pmid/36844503&rft_id=info:doi/10.1021/acscentsci.2c01359&rft.aulast=Hou&rft.aufirst=N&rft.au=Shuai, L&rft.au=Zhang, L&rft.au=Xie, X&rft.au=Tang, K&rft.au=Zhu, Y&rft.au=Yu, Y&rft.au=Zhang, W&rft.au=Tan, Q&rft.au=Zhong, G&rft.au=Wen, Z&rft.au=Wang, C&rft.au=He, X&rft.au=Huo, H&rft.au=Gao, H&rft.au=Xu, Y&rft.au=Xue, J&rft.au=Peng, C&rft.au=Zou, J&rft.au=Schindewolf, C&rft.au=Menachery, V&rft.au=Su, W&rft.au=Yuan, Y&rft.au=Shen, Z&rft.au=Zhang, R&rft.au=Yuan, S&rft.au=Yu, H&rft.au=Shi, PY&rft.au=Bu, Z&rft.au=Huang, J&rft.au=Hu, Q&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885526&rfr_id=info:sid/en.wikipedia.org:Iscartrelvir" class="Z3988">

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