In enzymology, an inositol 3-kinase (EC 2.7.1.64) is an enzyme that catalyzes the chemical reaction
| inositol 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.64 | ||||||||
| CAS no. | 37278-07-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- ATP myo-inositol ADP 1D-myo-inositol 3-phosphate
Thus, the two substrates of this enzyme are ATP and myo-inositol, whereas its two products are ADP and 1D-myo-inositol 3-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase. This enzyme participates in inositol phosphate metabolism.
References
edit- English PD, Dietz M, Albersheim P (1966). "Myoinositol kinase: partial purification and identification of product". Science. 151 (3707): 198–199. doi:10.1126/science.151.3707.198.198-199&rft.date=1966&rft_id=info:doi/10.1126/science.151.3707.198&rft.aulast=English&rft.aufirst=PD&rft.au=Dietz, M&rft.au=Albersheim, P&rfr_id=info:sid/en.wikipedia.org:Inositol 3-kinase" class="Z3988">
- and Loewus FA; Sasaki, K.; Leavitt, A. L.; Munsell, L.; Sherman, W. R.; Loewus, F. A. (1982). "Enantiomeric form of myo-inositol-1-phosphate produced by myo-inositol-1-phosphate synthase and myoinositol kinase in higher-plants". Plant Physiol. 70 (6): 1661–1663. doi:10.1104/pp.70.6.1661. PMC 1065950. PMID 16662739.1661-1663&rft.date=1982&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065950#id-name=PMC&rft_id=info:pmid/16662739&rft_id=info:doi/10.1104/pp.70.6.1661&rft.au=and Loewus FA&rft.au=Sasaki, K.&rft.au=Leavitt, A. L.&rft.au=Munsell, L.&rft.au=Sherman, W. R.&rft.au=Loewus, F. A.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065950&rfr_id=info:sid/en.wikipedia.org:Inositol 3-kinase" class="Z3988">
- Stephens LR, Kay RR, Irvine RF (1990). "A myo-inositol D-3 hydroxykinase activity in Dictyostelium". Biochem. J. 272 (1): 201–10. PMC 1149677. PMID 2176081.201-10&rft.date=1990&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149677#id-name=PMC&rft_id=info:pmid/2176081&rft.aulast=Stephens&rft.aufirst=LR&rft.au=Kay, RR&rft.au=Irvine, RF&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149677&rfr_id=info:sid/en.wikipedia.org:Inositol 3-kinase" class="Z3988">
