In enzymology, an inositol 2-dehydrogenase (EC 1.1.1.18) is an enzyme that catalyzes the chemical reaction
| inositol 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.18 | ||||||||
| CAS no. | 9028-25-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- myo-inositol NAD 2,4,6/3,5-pentahydroxycyclohexanone NADH H
Thus, the two substrates of this enzyme are myo-inositol and NAD , whereas its 3 products are 2,4,6/3,5-pentahydroxycyclohexanone, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is myo-inositol:NAD 2-oxidoreductase. Other names in common use include myo-inositol 2-dehydrogenase, myo-inositol:NAD oxidoreductase, inositol dehydrogenase, and myo-inositol dehydrogenase. This enzyme participates in inositol metabolism and inositol phosphate metabolism.
References
edit- Berman T, Magasanik B (1966). "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241 (4): 800–6. PMID 5905122.800-6&rft.date=1966&rft_id=info:pmid/5905122&rft.aulast=Berman&rft.aufirst=T&rft.au=Magasanik, B&rfr_id=info:sid/en.wikipedia.org:Inositol 2-dehydrogenase" class="Z3988">
- Larner J, Jackson WT, Graves DJ, Stamer JR (1956). "Inositol dehydrogenase from Aerobacter aerogenes". Arch. Biochem. Biophys. 60 (2): 352–63. doi:10.1016/0003-9861(56)90437-4. PMID 13292912.352-63&rft.date=1956&rft_id=info:doi/10.1016/0003-9861(56)90437-4&rft_id=info:pmid/13292912&rft.aulast=Larner&rft.aufirst=J&rft.au=Jackson, WT&rft.au=Graves, DJ&rft.au=Stamer, JR&rfr_id=info:sid/en.wikipedia.org:Inositol 2-dehydrogenase" class="Z3988">
- Vidal-Leiria M, van Uden N (1973). "Inositol dehydrogenase from the yeast Cryptococcus melibiosum". Biochim. Biophys. Acta. 293 (2): 295–303. doi:10.1016/0005-2744(73)90337-9. PMID 4351258.295-303&rft.date=1973&rft_id=info:doi/10.1016/0005-2744(73)90337-9&rft_id=info:pmid/4351258&rft.aulast=Vidal-Leiria&rft.aufirst=M&rft.au=van Uden, N&rfr_id=info:sid/en.wikipedia.org:Inositol 2-dehydrogenase" class="Z3988">
